Montelukast Tackled Epidermal Growth Factor Expression in Mouth Ulcer Model in Rats

  • Mohammed I. Majeed, Jawnaa K. Mammdoh, Luma I. Al-Allaf


Mouth cleansing is part of everyday activities to avoid oro-dental diseases. Despite that mouth, diseases are reported as a common cause for seeking medical help. Once this happens, oral ulceration continues for days or weeks depending on the personal oral hygiene. The mouth cavity contains different types of bacteria as a part of normal flora. Tissue layers are protected by the mucosa layer, and torn mucosa due to ulceration will expose tissue to the external environment resulting in infection and inflammation. The present study aimed at identifying the anti-inflammatory effects of montelukast via follow-up of their wound healing properties over different time points, compared to control. To do so, a rat mouth ulcer model was used by categorizing rats into 2 groups of 12 in each; montelukast versus the control group. Histology and Deposition of EGF as a healing marker detected by immunohistochemistry technique were used to compare montelukast versus control.  The outcome confirmed that montelukast accelerated the healing process confirmed by more EGF expression at the salivary glands and hence quicker healing resulting in reduced EGF expression at day 3 or 7 compared to the control group. In conclusion, montelukast has anti-inflammatory and wound healing properties which could make it a good candidate for future topical preparation formulation for burns and wounds.

Representative images for EGF expression by ulcer induced in tongue tissue on day 3 and day 7 in Montelukast treated versus the treatment-free control group. Montelukast has greatly modified EGF expression.
How to Cite
Jawnaa K. Mammdoh, Luma I. Al-Allaf, M. I. M. (2022). Montelukast Tackled Epidermal Growth Factor Expression in Mouth Ulcer Model in Rats. Revista Electronica De Veterinaria, 282 - 288. Retrieved from