Antioxidant And Anti-Inflammatory Activities Of Boswellia Serrata Leaf Extract: A Pharmacological Perspective
Keywords:
Boswellia serrata, Antioxidant, Oxidative stress, anti-inflammatory
Abstract
This study aimed to evaluate the antioxidant and anti-inflammatory activities of Boswellia serrata leaf extract using various in vitro mechanistic models. Building on its traditional use in managing inflammatory and oxidative stress-related disorders, Boswellia serrata has gained attention for its potential therapeutic benefits, largely attributed to its bioactive components, such as boswellic acids. The research employed several in vitro assays to assess the extract's ability to neutralize reactive oxygen species (ROS) and modulate the production of key pro-inflammatory cytokines, including IL-1β, TNF-α, and IL-6. Results demonstrated that the extract exhibits significant antioxidant activity, particularly at higher concentrations, effectively scavenging free radicals. Additionally, the extract showed a dose-dependent reduction in pro-inflammatory cytokine levels, suggesting its strong anti-inflammatory potential. These findings underscore the therapeutic promise of Boswellia serrata leaf extract as a natural remedy for conditions characterized by oxidative stress and chronic inflammation. The study provides a solid foundation for further research into the specific bioactive compounds responsible for these effects and their possible applications in clinical settings.
References
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25. Guo Y, Zhang P, Liu Y, Zha L, Ling W, Guo H. A dose-response evaluation of purified anthocyanins on inflammatory and oxidative biomarkers and metabolic risk factors in healthy young adults: A randomized controlled trial. Nutrition. 2020;74:110745.
26. Singh S, Kaur R, Sharma SK. Antinociceptive, antiinflammatory and antipyretic activities of Rumex hastatus D. don stem and roots. Der Pharmacia Sinica. 2013;4(3):95-102.
27. Siddiqui MZ. Boswellia serrata, a potential antiinflammatory agent: an overview. Indian journal of pharmaceutical sciences. 2011;73(3):255-61.
28. Joshi SK, Sharma BD, Bhatia CR, Singh RV, Thakur RS. The wealth of India raw materials. Council of Scientific and Industrial Research Publication, New Delhi. 1992;3:270-1.
29. Chiavari G, Galletti GC, Piccaglia R, Mohamud MA. Differentiation between resins Boswellia carterii and Boswellia frereana (frankincense) of Somali origin. Journal of Essential Oil Research. 1991;3(3):185-6.
30. Khare CP. Botany, Indian Herbal Remedies: Rational Western Therapy, Ayurvedic, and Other Traditional Usage. Springer, New York; 2004.
31. Nenadis N, Wang L-F, Tsimidou M, Zhang H-Y. Estimation of scavenging activity of phenolic compounds using the ABTS•+ assay. Journal of agricultural and food chemistry. 2004;52(15):4669-74.
32. Lee BW, Lee JH, Gal SW, Moon YH, Park KH. Selective ABTS radical-scavenging activity of prenylated flavonoids from Cudrania tricuspidata. Bioscience, biotechnology, and biochemistry. 2006;70(2):427-32.
33. Tijani AA, Adekomi DA, Adewole SO. In vitro and in vivo determination of hydroxyl radical scavenging activity (HRSA) of fractions of aqueous extract of Moringa oleifera leaves (AEMOL). Eurasian J Med Oncol. 2018;2(4):209-16.
34. Moro C, Palacios I, Lozano M, D’Arrigo M, Guillamón E, Villares A, et al. Anti-inflammatory activity of methanolic extracts from edible mushrooms in LPS activated RAW 264.7 macrophages. Food chemistry. 2012;130(2):350-5.
35. Cherng S-C, Cheng S-N, Tarn A, Chou T-C. Anti-inflammatory activity of c-phycocyanin in lipopolysaccharide-stimulated RAW 264.7 macrophages. Life sciences. 2007;81(19-20):1431-5.
2. Abrahamovych M, Abrahamovych O, Fayura O, Fayura L, Tolopko S. THE EFFECT OF OXIDATIVE STRESS ON THE AUTONOMIC NERVOUS SYSTEM IN PATIENTS WITH LIVER CIRRHOSIS. Georgian Med News. 2020(298):94-9.
3. Adamczyk B, Wawrzyniak S, Kasperczyk S, Adamczyk-Sowa M. The Evaluation of Oxidative Stress Parameters in Serum Patients with Relapsing-Remitting Multiple Sclerosis Treated with II-Line Immunomodulatory Therapy. Oxid Med Cell Longev. 2017;2017:9625806.
4. Adema AY, van Ittersum FJ, Hoenderop JG, de Borst MH, Nanayakkara PW, Ter Wee PM, et al. Reduction of Oxidative Stress in Chronic Kidney Disease Does Not Increase Circulating α-Klotho Concentrations. PLoS One. 2016;11(1):e0144121.
5. Akbulak O, Karadag AS, Akdeniz N, Ozkanli S, Ozlu E, Zemheri E, et al. Evaluation of oxidative stress via protein expression of glutathione S-transferase and cytochrome p450 (CYP450) ısoenzymes in psoriasis vulgaris patients treated with methotrexate. Cutan Ocul Toxicol. 2018;37(2):180-5.
6. Akhgarjand C, Vahabi Z, Shab-Bidar S, Anoushirvani A, Djafarian K. The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled study. Inflammopharmacology. 2024;32(2):1413-20.
7. Al-Sheikh YA, Al-Zahrani KY. The Status of Biochemical and Molecular Markers of Oxidative Stress in Preeclamptic Saudi Patients. Curr Mol Med. 2018;18(7):475-85.
8. Anraku M, Tanaka M, Hiraga A, Nagumo K, Imafuku T, Maezaki Y, et al. Effects of chitosan on oxidative stress and related factors in hemodialysis patients. Carbohydr Polym. 2014;112:152-7.
9. Arab A, Khorvash F, Karimi E, Heidari Z, Askari G. The effects of the dietary approaches to stop hypertension (DASH) diet on oxidative stress and clinical indices of migraine patients: a randomized controlled trial. Nutr Neurosci. 2022;25(11):2259-68.
10. Asemi Z, Samimi M, Tabassi Z, Shakeri H, Sabihi SS, Esmaillzadeh A. Effects of DASH diet on lipid profiles and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized clinical trial. Nutrition. 2014;30(11-12):1287-93.
11. Atan RM, Ersoy G, Çakıcı Ç. Effects of Hardaliye, a Fermented Grape Drink, on Oxidative Stress, Lipid Profile, and Blood Pressure in Young Soccer Players: A Randomized Controlled Trial. J Am Nutr Assoc. 2024;43(4):356-64.
12. Abedini M, Ramezani-Jolfaie N, Ghasemi-Tehrani H, Tarrahi MJ, Amani R. The effect of concentrated pomegranate juice on biomarkers of inflammation, oxidative stress, and sex hormones in overweight and obese women with polycystic ovary syndrome: A randomized controlled trial. Phytother Res. 2023;37(6):2255-61.
13. Adams JM, Valentine CJ, Karns RA, Rogers LK, Murase M, Fowler GN, et al. DHA Supplementation Attenuates Inflammation-Associated Gene Expression in the Mammary Gland of Lactating Mothers Who Deliver Preterm. J Nutr. 2022;152(6):1404-14.
14. Ağbaş A, Canpolat N, Çalışkan S, Yılmaz A, Ekmekçi H, Mayes M, et al. Hemodiafiltration is associated with reduced inflammation, oxidative stress and improved endothelial risk profile compared to high-flux hemodialysis in children. PLoS One. 2018;13(6):e0198320.
15. Burbank AJ, Hernandez ML, Robinette C, Wang T, Zhou H, Alexis N, et al. Short course gamma tocopherol did not mitigate effects of ozone on airway inflammation in asthmatics. Inhal Toxicol. 2020;32(7):279-81.
16. Chai SC, Davis K, Zhang Z, Zha L, Kirschner KF. Effects of Tart Cherry Juice on Biomarkers of Inflammation and Oxidative Stress in Older Adults. Nutrients. 2019;11(2).
17. Silva FF, de Oliveira GAC, Costa HCM, Regis WCB. Royal Sun Culinary-Medicinal Mushroom, Agaricus brasiliensis (Agaricomycetes), Supplement in Training Capacity Improvement Parameters. Int J Med Mushrooms. 2017;19(9):759-66.
18. Spim SRV, Pistila AMH, Pickler TB, Silva MT, Grotto D. Effects of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Bars on Lipid and Antioxidant Profiles in Individuals with Borderline High Cholesterol: A Double-Blind Randomized Clinical Trial. Int J Med Mushrooms. 2021;23(7):1-12.
19. Ved DK, Goraya GS. Demand and supply of medicinal plants in India. New Delhi: National Medicinal Plants Board; 2008 2010 Nov 1.
20. Singh N, Ahuja V, Sachdev V, Upadhyay AD, Goswami R, Ramakrishnan L, et al. Antioxidants for Pancreatic Functions in Chronic Pancreatitis: A Double-blind Randomized Placebo-controlled Pilot Study. J Clin Gastroenterol. 2020;54(3):284-93.
21. Soto-Méndez MJ, Aguilera CM, Mesa MD, Campaña-Martín L, Martín-Laguna V, Solomons NW, et al. Strong Associations Exist among Oxidative Stress and Antioxidant Biomarkers in the Circulating, Cellular and Urinary Anatomical Compartments in Guatemalan Children from the Western Highlands. PLoS One. 2016;11(1):e0146921.
22. Souza AV, Giolo JS, Teixeira RR, Vilela DD, Peixoto LG, Justino AB, et al. Salivary and Plasmatic Antioxidant Profile following Continuous, Resistance, and High-Intensity Interval Exercise: Preliminary Study. Oxid Med Cell Longev. 2019;2019:5425021.
23. Stankiewicz B, Cieślicka M, Kujawski S, Piskorska E, Kowalik T, Korycka J, et al. Effects of antioxidant supplementation on oxidative stress balance in young footballers- a randomized double-blind trial. J Int Soc Sports Nutr. 2021;18(1):44.
24. Stenqvist A, Oleszczuk K, Leijonhufvud I, Giwercman A. Impact of antioxidant treatment on DNA fragmentation index: a double-blind placebo-controlled randomized trial. Andrology. 2018;6(6):811-6.
25. Guo Y, Zhang P, Liu Y, Zha L, Ling W, Guo H. A dose-response evaluation of purified anthocyanins on inflammatory and oxidative biomarkers and metabolic risk factors in healthy young adults: A randomized controlled trial. Nutrition. 2020;74:110745.
26. Singh S, Kaur R, Sharma SK. Antinociceptive, antiinflammatory and antipyretic activities of Rumex hastatus D. don stem and roots. Der Pharmacia Sinica. 2013;4(3):95-102.
27. Siddiqui MZ. Boswellia serrata, a potential antiinflammatory agent: an overview. Indian journal of pharmaceutical sciences. 2011;73(3):255-61.
28. Joshi SK, Sharma BD, Bhatia CR, Singh RV, Thakur RS. The wealth of India raw materials. Council of Scientific and Industrial Research Publication, New Delhi. 1992;3:270-1.
29. Chiavari G, Galletti GC, Piccaglia R, Mohamud MA. Differentiation between resins Boswellia carterii and Boswellia frereana (frankincense) of Somali origin. Journal of Essential Oil Research. 1991;3(3):185-6.
30. Khare CP. Botany, Indian Herbal Remedies: Rational Western Therapy, Ayurvedic, and Other Traditional Usage. Springer, New York; 2004.
31. Nenadis N, Wang L-F, Tsimidou M, Zhang H-Y. Estimation of scavenging activity of phenolic compounds using the ABTS•+ assay. Journal of agricultural and food chemistry. 2004;52(15):4669-74.
32. Lee BW, Lee JH, Gal SW, Moon YH, Park KH. Selective ABTS radical-scavenging activity of prenylated flavonoids from Cudrania tricuspidata. Bioscience, biotechnology, and biochemistry. 2006;70(2):427-32.
33. Tijani AA, Adekomi DA, Adewole SO. In vitro and in vivo determination of hydroxyl radical scavenging activity (HRSA) of fractions of aqueous extract of Moringa oleifera leaves (AEMOL). Eurasian J Med Oncol. 2018;2(4):209-16.
34. Moro C, Palacios I, Lozano M, D’Arrigo M, Guillamón E, Villares A, et al. Anti-inflammatory activity of methanolic extracts from edible mushrooms in LPS activated RAW 264.7 macrophages. Food chemistry. 2012;130(2):350-5.
35. Cherng S-C, Cheng S-N, Tarn A, Chou T-C. Anti-inflammatory activity of c-phycocyanin in lipopolysaccharide-stimulated RAW 264.7 macrophages. Life sciences. 2007;81(19-20):1431-5.
Published
2024-09-17
How to Cite
Palash Chandra Biswas, Brijesh Kumar Saroj, Senthil Kumar Raju, Konda V V S Krishna, Rajesh Kumar Mukherjee, Nehal P, Abdul Kadir Jilani, Abdul Kadir Jilani, & Seena Kx. (2024). Antioxidant And Anti-Inflammatory Activities Of Boswellia Serrata Leaf Extract: A Pharmacological Perspective. Revista Electronica De Veterinaria, 25(1), 1451 -1460. https://doi.org/10.69980/redvet.v25i1.925
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