Mindfulness of Functional Foods in Cancer Prevention and Health Promotion: A Comprehensive Review

  • Suman Bala
  • Garima Singh
  • Manmeet Kaur
Keywords: Cancer, Functional foods, vitamins, antioxidants

Abstract

Cancer is a major cause of death in the world. Common cancers include prostate cancer, breast cancer, bladder cancer, colorectal cancer, and skin cancers. Treatment of cancer is very expensive hence the need to prevent the condition primarily, or even secondarily. Foods, like chemicals, have cumulative effects and contain substances both essential and non-essential which have been shown to be healthy. Functional foods with intrinsic mixture of bioactive anti-cancer compounds could be very effective medium to contain menace caused by cancer. The health promoting effect of fruits and vegetable is indisputable. The primary role of diet is to provide sufficient nutrients to meet the nutritional requirements of an individual. There is now increasing scientific evidence to support the hypothesis that some foods and food components have beneficial physiological and psychological effects over and above the provision of the basic nutrients. Functional foods can be considered to be those whole, fortified, enriched or enhanced foods that provide health benefits beyond the provision of essential nutrients (e.g., vitamins and minerals), when they are consumed at efficacious levels as part of a varied diet on a regular basis. Linking the consumption of functional foods or food ingredients with health claims should be based on sound scientific evidence, with the “gold standard”.  However, not all foods on the market today that are claimed to be functional foods are supported by enough solid data to merit such claims. This review categorizes a variety of functional foods according to the type of evidence supporting their functionality, the strength of that evidence, the recommended intakes and their role in cancer prevention.

Author Biographies

Suman Bala

Assistant Professor, Department of Home Science, Kurukshetra University, 136119 Kurukshetra- Haryana, India.

Garima Singh

Assistant Professor, Department of Nutrition and Health, G.D. Goenka University, 122103 Gurugram- Haryana, India. 

Manmeet Kaur

Extension Lecturer, department of Home Science, Pt. C.L.S Govt. College Karnal- Haryana, India 

References

[1] Albanes, D. et al. Effects of alpha-tocopherol and beta-carotene supplements on cancer incidence in the Alpha-Tcopherol Beta-Carotene Cancer Prevention Study. Am. J. Clin. Nutr. 62, 1427S–1430S (1995).
[2] Arai, S. (1996) Studies on functional foods in Japan—state of the art. Biosci. Biotechnol. Biochem.60:9–15.
[3] Asgari M.M., Chren M., Warton E.M., Friedman G.D., White E. (2011). supplement use and risk of cutaneous squamous cell carcinoma. J Am Acad Dermatol, 65(6): 1145- 1151
[4] Avorn, J., Monane, M., Gurwitz, J. H., Glynn, R. J., Choodnovskiy, I. & Lipsitz, L. A. (1994) Reduction of bacteriuria and pyuria after ingestion of cranberry juice. J. Am. Med. Assoc.271:751–754.
[5] Bragg FL, Smith M, Guo Y, Chen Y, Millwood I, Bian Z, Walters R, Chen J, Yang L, Collins R, Peto R, Lu Y, Yu B, Xie X, Lei Y, Luo G, Chen Z China Kadoorie Biobank Collaborative Group. Associations of blood glucose and prevalent diabetes with risk of cardiovascular disease in 500,000 adult Chinese: the China Kadoorie Biobank. Diabet Med. 2014; 31: 540–51.
[6] Brasky T.M., Kristal A.R., Navarro S.L., Lampe J.W., Patterson R.E., Peters U., White E. (2011). Specialty supplements and prostate cancer risk in the Vitamins and Lifestyle (VITAL) Cohort. Nutr Cancer, 63(4): 573-582
[7] Carpentera C.L., Yu M.C., London S.J. (2009). Dietary isothiocyanates, Glutathione STransferase M1 (GSTM1), and lung cancer risk in African Americans and Caucasians from Los Angeles County, California. Nutr Cancer, 61(4): 492-499
[8] Chiller JT, Lowy DR. Virus infection and human cancer: an overview. Recent Results Cancer Res. 2014; 193:1–10.
[9] Committee on Opportunities in the Nutrition and Food Sciences, Food and Nutrition Board, Institute of Medicine (1994) Enhancing the food supply. Thomas, P. R. Earl, R. eds. Opportunities in the Nutrition and Food Sciences: Research Challenges and the Next Generation of Investigators: 98–142 National Academy Press Washington, DC.
[10] Di Mascio P, Kaiser S & Sies H (1989) Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Archives Biochemistry and Biophysics 274, 532–538.
[11] Elegbede JA, Maltzman TH, Elson CE & Gould MN (1993) Effects of anticarcinogenic monoterpenes on phase II hepatic metabolizing enzymes. Carcinogenesis 14, 1221–1223.
[12] Food and Agriculture Organization of the United Nations (FAO) Report on Functional Foods, Food Quality and Standards Service (AGNS) Available online: http://www.fao.org/ag/agn/agns/files/Functional_Foods_Report_Nov2007. pdf.
[13] Guha N., Kwan M.L., Quesenberry Jr C.P., Weltzien E.K., Castillo A.L., Caan B.J. (2009). Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: Life After Cancer Epidemiology (LACE) Study. Breast Cancer Res Treat, 118(2): 395-405
[14] Gupta S., Hastak K., Ahmad N., Lewin J.S., Mukhtar H. (2008). Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols. Proc Natl Acad Sci, 98: 10350-10355
[15] Ha YL, Grimm NK & Pariza MW (1987) Anticarcinogens from fried ground beef: health-altered derivatives of linoleic acid. Carcinogenesis 8, 1881–1887.
[16] He N.W., Zhao Y., Guo L., Shang J., Yang X.B. (2012). Antioxidant, antiproliferative, and pro-apoptotic activities of a saponin extract derived from the roots of Panax notoginseng (Burk.) F.H. Chen. J Med Food, 15 (4): 350-359
[17] Iwasaki M., Inoue M., Sasazuki S., Miura T. et al. (2010). Plasma tea polyphenol levels and subsequent risk of breast cancer among Japanese women: A Nested Case-Control Study. Breast Cancer Res Treat, 124(3): 827-34
[18] Katiyar S.K. (2008). Grape seed pro anthocyanidines and skin cancer prevention: inhibition of oxidative stress and protection of immune system. Mol Nutr Food Res, 52(1): S71-S76
[19] Lee S., Shu X., Li H., Yang G., Cai H., Wen W., Ji B., Gao J., Gao Y., Zheng W. (2009). Adolescent and adult soy food intake and breast cancer risk: Results from the Shanghai Women’s Health Study. Am J Clin Nutr, 89: 1920-6
[20] Letter regarding dietary supplement health claim for omega-3 fatty acids and coronary heart disease (docket no. 91N-0103) U.S. Food and Drug Administration http://vm.cfsan.fda.gov/dms/ds-ltr28.html. Last accessed, October 10, 2002.
[21] McCormick D.L., Rao K.V.N., Johnson W.D., Bosland M.C., Lubet R.A., Steele V.E. (2010). Null activity of selenium and vitamin E as cancer chemopreventive agents in the rat prostate. Cancer Prev Res (Phila), 3(3): 381-392
[22] Messina M., Hilakivi-Clarke L. (2009). Early intake appears to be the key to the proposed protective effects of soy intake against breast cancer. Nutr Cancer, 61(6):792- 798
[23] Park D.H., Shin J.W., Park S.K., et al. (2009). Diethylnitrosamine (DEN) induces irreversible hepatocellular carcinogenesis through overexpression of G1/S-phase regulatory proteins in rat. Toxi-col Lett, 191: 321-326
[24] Phipps WR, Martini MC, Lampe JW, Slavin JL & Kurzer MS (1993) Effect of flax seed ingestion on the menstrual cycle. Journal of Clinical Endocrinology and Metabolism 77, 1215–1219.
[25] Rey-Ares, L., Ciapponi, A. & Pichon-Riviere, A. Efficacy and safety of human papilloma virus vaccine in cervical cancer prevention: systematic review and metaanalysis. Arch. Argent. Pediatr. 110, 483–489 (2012)
[26] Sarriá B., Martínez-López S., Fernández-Espinosa A., Gómez-Juaristi M., Goya L., Mateos R., Bravo L. (2012). Effects of regularly consuming dietary fibre rich soluble cocoa products on bowel habits in healthy subjects: a free-living, two-stage, randomized, crossover, single-blind intervention. Nutrition & Metabolism, 9: 33
[27] Shu X.O., Zheng Y., Cai H., Gu K., Chen Z., Zheng W., et al. (2009). Soy food intake and breast cancer survival. JAMA. 302(22): 2437-2443
[28] Singh, G., Bala, S., Rastogi, M., Noviar, R., Naveel, T., Ramanathan, T., & Kumar, S., A. Comprehensive look of renal calculi in kidneys: A review (2022) NeuroQuantology 20 (5) 4404-4412.
[29] Singh, G. and Kochar, G.K. (2010). Zinc content of commonly consumed foods of Kurukshetra district of Haryana. Food Sci. Res. J. 1(2), 94-98.
[30] Singh S.V., Powolny A.A., Stan S.D., Xiao D., Arlotti J.A., Warin R., Hahm E., Marynowski S.W., Bommareddy A., Potter D.M., Dhir R. (2008). Garlic constituent diallyl trisulfide prevents development of poorly-differentiated prostate cancer and pulmonary metastasis multiplicity in TRAMP mice. Cancer Res, 68(22): 9503-9511
[31] Stan S.D., Singh S.V. (2009). Transcriptional Repression and Inhibition of Nuclear Translocation of Androgen Receptor by Diallyl Trisulfide in Human Prostate Cancer Cells. Clin Cancer Res, 15(15): 4895-4903
[32] Thoppil R.J., Bishayee A. (2011). Terpenoids as potential chemopreventive and therapeutic agents in liver cancer. World J Hepatol, 3(9): 228-249
[33] Vel Szic KS, Palagani A, Hassannia B. Phytochemicals and cancer chemoprevention: epigenetic friends or foe? In: Rasooli I, editor. Phytochemicals-bioactivities and impact on health, InTech, Janeza Trdine 9, 51000 Rijeka, Croatia. 2011.
[34] Vineis, P. & Wild, C. P. Global cancer patterns: causes and prevention. Lancet 383, 549–557 (2014).
[35] Wang C., Aung H.H., Zhang B., Sun S., Li X., He H., Xie J., He T., Du W., Yuan C. (2008). chemopreventive effects of heat-processed Panax quinquefolius root on human breast cancer cells. Anticancer Res, 28(5A): 2545-2551
[36] World Cancer Research Fund/American Institute for Cancer Research. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. [online], http://www.aicr.org/assets/docs/pdf/reports/Second_ Expert_Report.pdf (2007).
[37] Wu A.H., Koh W.P., Wang R., Lee H.P., Yu M.C. (2008). Soy intake and breast cancer risk in singapore chinese health study. Br J Cancer, 99: 196-200
Published
2024-09-09
How to Cite
Suman Bala, Garima Singh, & Manmeet Kaur. (2024). Mindfulness of Functional Foods in Cancer Prevention and Health Promotion: A Comprehensive Review. Revista Electronica De Veterinaria, 25(1), 1181-1187. https://doi.org/10.69980/redvet.v25i1.800
Section
Articles