“Synthesis, physiochemical evaluation, characterization, and anticancer activity of derivatives containing 4-((2,3-dihydro-4H-1,4-oxazin-4-yl) sulfonyl) aniline”

  • Sonam Tiwari
  • Dr. Arun Patel
  • Dr. Shailendra Patel
Keywords: Carcinogenesis, NCI-H226, DHFR, radiotherapy, neuroendocrine carcinoma, ect.

Abstract

Medicinal chemistry focuses on the exploration and advancement of new pharmaceuticals for the treatment of diseases. The primary objective of the field is to create innovative organic molecules, whether they are naturally occurring or artificially synthesised. Heterocyclic nuclei are a substantial part of these chemical molecules. Sulphonamide based acetamide molecules are   currently   being   utilised   in   the   development   of   novel   anticancer   medicines. The physicochemical characteristics of the synthesised substance (SA-1 to SA-11) were documented. The chemical SA-1 to SA-11 has been characterised using infrared spectroscopy (IR), proton nuclear magnetic resonance (1HNMR), carbon-13 nuclear magnetic resonance (13CNMR), and mass spectral analysis. Additionally, all the other synthesised compounds have exhibited a molecular ion peak that is analogous to their respective molecular formula and weight. The synthesised compounds were assessed for their anticancer activity against the NCI- H226 lung cancer cell line using the SRB test technique. The MTT experiment indicated that compounds SA-1, SA-2, SA-3, SA-4, and SA-11 had significant efficacy against the Lung cancer cell line. It demonstrated a significant cytotoxic effect on both cell types, particularly on the WI-38 normal lung fibroblast cells and NCI-H226 lung cancer cells. Evidently, all compounds that were examined demonstrate a notable induction of cell death, except for SA- 1, SA-2, SA-3, SA-4, SA-5, and SA-11, which had IC50 values of 1866.20, 1702.23, 1374.35, 1625.10, 1200, and 2959.16 µg/ml, respectively.

Author Biographies

Sonam Tiwari

SRGI- Shri Ram Group of Institution, Department of pharmacy, Jabalpur-482002 Madhya Pradesh, India

Dr. Arun Patel

SRGI- Shri Ram Group of Institution, Department of pharmacy, Jabalpur-482002 Madhya Pradesh, India

Dr. Shailendra Patel

SRGI- Shri Ram Group of Institution, Department of pharmacy, Jabalpur-482002 Madhya Pradesh, India

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Published
2024-01-25
How to Cite
Sonam Tiwari, Dr. Arun Patel, & Dr. Shailendra Patel. (2024). “Synthesis, physiochemical evaluation, characterization, and anticancer activity of derivatives containing 4-((2,3-dihydro-4H-1,4-oxazin-4-yl) sulfonyl) aniline”. Revista Electronica De Veterinaria, 25(1), 793-802. Retrieved from https://www.veterinaria.org/index.php/REDVET/article/view/713
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Articles