“Enhance the Loading Capacity of Carbon Containing Nano-Carriers through Surface Modification”

  • Shraddha Jain
  • Dr. Arun Patel
  • Dr. Shailendra Patel
Keywords: Carbon nanotubes (CNT), Single-walled carbon nanotubes (SWCNT), graphene, nano-diamond, drug delivery system, surface modification.

Abstract

Introduction: Drug delivery systems (DDS) aim to enhance drug release by targeting tissues and reducing dosages. Carbon nanotubes (CNTs), with superior mechanical, electrical, optical, and thermal properties, show promise for DDS. It can improve polymer matrices' thermal and mechanical properties. However, current DDS have drug loading capacities below 10%. CNTs' high surface area offers potential for large-scale delivery. Modifying CNT surfaces with hydrophilic or amphiphilic polymers can boost loading capacity, and chemical functionalization can enhance biocompatibility.

Objective: This study investigates improving CNT-based drug delivery systems by enhancing drug loading capacity, solubility, and biocompatibility through surface modifications. It aims to boost loading capacity with various surface modifications, increase biocompatibility via chemical functionalization, and evaluate covalent functionalization's impact on solubility and dispersibility, advancing the development of more effective CNT-based drug delivery systems.

Method: Single-walled carbon nanotubes (SWCNTs) were oxidized using sulfuric acid (H2SO4) and nitric acid (HNO3) at 100°C for 2 hours. The oxidized SWCNTs were then converted into acyl chloride groups with thionyl chloride (SOCl2) in tetrahydrofuran (THF), followed by amino-functionalization. Infrared (IR) spectroscopy was used to analyze the functionalized CNTs and identify characteristic peaks indicating successful carboxylation.

Results: IR spectra indicate successful SWCNT oxidation, showing peaks for carboxyl groups (C=O at 1633.76 cm⁻¹). This functionalization enhances solubility and dispersibility, improving SWCNT suitability for drug delivery applications.

Conclusion: The study demonstrates CNTs' potential in DDS, showing improved drug loading capacity, solubility, and biocompatibility via surface modifications, with functionalized SWCNTs as promising drug carriers.

Author Biographies

Shraddha Jain

SRGI- Shri Ram Group of Institutions, Department of Pharmacy, Jabalpur-482002, Madhya

Dr. Arun Patel

SRGI- Shri Ram Group of Institutions, Department of Pharmacy, Jabalpur-482002, Madhya

Dr. Shailendra Patel

SRGI- Shri Ram Group of Institutions, Department of Pharmacy, Jabalpur-482002, Madhya

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Published
2024-01-25
How to Cite
Shraddha Jain, Dr. Arun Patel, & Dr. Shailendra Patel. (2024). “Enhance the Loading Capacity of Carbon Containing Nano-Carriers through Surface Modification”. Revista Electronica De Veterinaria, 25(1), 783-792. Retrieved from https://www.veterinaria.org/index.php/REDVET/article/view/711
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Articles