Antibiotic property of ZnO nanoparticles embedded PMMA bone cements.
Abstract
Background: Bone cement with a polymethyl methacrylate (PMMA) basis has been utilised as a bone filler or to anchor hip and knee implants. Although PMMA-based bone cement is frequently utilised and enables quick primary fixation to the bone, it cannot ensure a mechanically and physiologically stable interface with bone and is, more importantly, prone to bacterial adhesion and infection development.
Aim: To analyse the antibiotic property of ZnO nanoparticles embedded PMMA bone cements.
Materials and methods: This work aims to study gentamicin release from ZnO nanoparticles incorporated in polymethyl methacrylate (PMMA) bone cement Different concentrations were tested with the presence of gentamicin as a powder . The different types of bone cement were tested for drug release, mechanical properties, water uptake, antimicrobial properties, and cytocompatibility with human osteoblast cells.
Results: The results showed negative results, as they didnt have any effect of antibiotic property on PMMA bone cements.
Conclusion:There is a good scope for this study which may be uptaken in the future and prove positive results.
References
2. Abboud M, Casaubieilh L, Morvan F, Fontanille M, Duguet E. PMMA-based composite materials with reactive ceramic fillers: IV. Radiopacifying particles embedded in PMMA beads for acrylic bone cements [Internet]. Vol. 53, Journal of Biomedical Materials Research. 2000. p. 728–36. Available from: http://dx.doi.org/10.1002/1097-4636(2000)53:6<728::aid-jbm16>3.0.co;2-a
3. El-Masry RM, Talat D, Hassoubah SA, Zabermawi NM, Eleiwa NZ, Sherif RM, et al. Evaluation of the Antimicrobial Activity of ZnO Nanoparticles against Enterotoxigenic. Life [Internet]. 2022 Oct 20;12(10). Available from: http://dx.doi.org/10.3390/life12101662
4. Sreeja R, John J, Aneesh PM, Jayaraj MK. Linear and nonlinear optical properties of luminescent ZnO nanoparticles embedded in PMMA matrix [Internet]. Vol. 283, Optics Communications. 2010. p. 2908–13. Available from: http://dx.doi.org/10.1016/j.optcom.2010.02.044
5. Prokopovich P, Perni S, Thenault V, Abdo P, Margulis K, Magdassi S. Antimicrobial activity of bone cements embedded with organic nanoparticles [Internet]. International Journal of Nanomedicine. 2015. p. 6317. Available from: http://dx.doi.org/10.2147/ijn.s86440
6. Kühn KD. Mechanical Properties of PMMA Cements [Internet]. PMMA Cements. 2013. p. 183–202. Available from: http://dx.doi.org/10.1007/978-3-642-41536-4_12
7. Kühn KD. Fatigue properties of PMMA cements [Internet]. PMMA Cements. 2013. p. 217–30. Available from: http://dx.doi.org/10.1007/978-3-642-41536-4_14
8. Frommelt L. Gentamicin Release from PMMA Bone Cement: Mechanism and Action on Bacteria [Internet]. Bone Cements and Cementing Technique. 2001. p. 119–25. Available from: http://dx.doi.org/10.1007/978-3-642-59478-6_10
9. Shukla AK, Iravani S. Green Synthesis, Characterization and Applications of Nanoparticles. Elsevier; 2018. 548 p.
10. Rahman F, Majed Patwary MA, Bakar Siddique MA, Bashar MS, Haque MA, Akter B, et al. Green synthesis of zinc oxide nanoparticles using leaf extract: characterization, antimicrobial, antioxidant and photocatalytic activity. R Soc Open Sci. 2022 Nov;9(11):220858.
11. Lunz A, Knappe K, Omlor GW, Schonhoff M, Renkawitz T, Jaeger S. Mechanical strength of antibiotic-loaded PMMA spacers in two-stage revision surgery. BMC Musculoskelet Disord. 2022 Oct 29;23(1):945.
12. Ferraris S, Miola M, Bistolfi A, Fucale G, Crova M, Massé A, et al. In vitro comparison between commercially and manually mixed antibiotic-loaded bone cements. J Appl Biomater Biomech. 2010 Sep-Dec;8(3):166–74.
13. Kühn KD. Bone Cements: Up-to-Date Comparison of Physical and Chemical Properties of Commercial Materials. Springer Science & Business Media; 2012. 272 p.
14. Donlan RM, Costerton JW. Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev. 2002 Apr;15(2):167–93.
