Meta-Analysis of Motor Protein KIF14 with Reference to Cancer
Keywords:
Receptor threonine kinase, KIF14, Protein regulating cytokinesis 1, Citron kinase, Motor protein, Lung cancer
Abstract
Comprehensive genetic profiling is anticipated to change the way cancer is treatment. KIF14 signaling is responsible for carcinogenesis in a number of malignancies. From this angle, we talk about how often KIF14 mutations and copy number alterations are in different solid tumors. In order to gather information on KIF14 transformation and augmentation from various cancers, we used important data sets such as cBioportal, PubMed, and COSMIC. Our studies describe the clinical data for many malignancies induced by the KIF14 (kinesin family member 14) mutations alter specific regions of the human, Alterations in the KIF14 protein may serve as potential biomarkers for confirming malignant progression. Amino acid and nucleotide variations have been documented across several cancer types. In this review, we provide a comprehensive analysis of these alterations in various malignancies. Our findings indicate that missense mutations are the most prevalent across all cancer types, underscoring the distribution and frequency of KIF14 mutations in different tumor tissues.
References
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[13] Wang, W., Zhang, R., Wang, X., Wang, N., Zhao, J., Wei, Z., ... & Wang, C. (2020). Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb‐E2F signaling and epithelial‐mesenchymal transition. Cancer science, 111(4), 1422-1434. https://doi.org/10.1111/cas.14324
[14] Ayala, F. R. R., Martin, J. W., & Bertuzzo, C. S. (2023). Replication Timing Aberration of KIF14 and MDM4/PI3KC 2 β Alleles and Aneuploidy as Markers of Chromosomal Instability and Poor Treatment Response in Ewing Family Tumor Patients. Global Medical Genetics, 10(02), 054-062. https://doi.org/10.1055/s-0043-1768238
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[16] Sivakumar, M., Jayakumar, M., Seedevi, P., Sivasankar, P., Ravikumar, M., Surendar, S., ... & Loganathan, S. (2020). Meta-analysis of functional expression and mutational analysis of c-Met in various cancers. Current Problems in Cancer, 44(4), 100515. https://doi.org/10.1016/j.currproblcancer.2019.100515
[17] Crosas-Molist, E., Samain, R., Kohlhammer, L., Orgaz, J. L., George, S. L., Maiques, O., ... & Sanz-Moreno, V. (2022). Rho GTPase signaling in cancer progression and dissemination. Physiological Reviews, 102(1), 455-510. https://doi.org/10.1152/physrev.00045.2020
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[19] Li, X., Huang, W., Huang, W., Wei, T., Zhu, W., Chen, G., & Zhang, J. (2020). Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma. American Journal of Translational Research, 12(5), 1614. PMID: 32509165
[20] Liu, J., Li, D., Zhang, X., Li, Y., & Ou, J. (2020). Histone demethylase KDM3A promotes cervical cancer malignancy through the ETS1/KIF14/hedgehog Axis. OncoTargets and therapy, 13, 11957. https://doi.org/10.2147%2FOTT.S276559
[21] Hanicinec, V., Brynychova, V., Rosendorf, J., Palek, R., Liska, V., Oliverius, M., ... & Soucek, P. (2021). Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer. Oncology Letters, 22(2), 1-12. https://doi.org/10.3892/ol.2021.12859
[22] Klimaszewska-Wiśniewska, A., Neska-Długosz, I., Buchholz, K., Durślewicz, J., Grzanka, D., Kasperska, A., ... & Gagat, M. (2021). Prognostic significance of KIF11 and KIF14 expression in pancreatic adenocarcinoma. Cancers, 13(12), 3017. https://doi.org/10.3390/cancers13123017
[23] Zhang, X., Li, L., Huang, S., Liao, W., Li, J., Huang, Z., ... & Lian, Y. (2022). Comprehensive analysis of ANLN in human tumors: A prognostic biomarker associated with cancer immunity. Oxidative Medicine and Cellular Longevity, 2022(1), 5322929. https://doi.org/10.3390/ijms22189732
[24] Mandal, K., Pogoda, K., Nandi, S., Mathieu, S., Kasri, A., Klein, E., ... & Manneville, J. B. (2019). Role of a kinesin motor in cancer cell mechanics. Nano letters, 19(11), 7691-7702. https://doi.org/10.1021/acs.nanolett.9b02592
[25] Halcrow, E. F., Mazza, R., Diversi, A., Enright, A., & D’Avino, P. P. (2022). Midbody proteins display distinct dynamics during cytokinesis. Cells, 11(21), 3337. https://doi.org/10.3390/cells11213337
[26] Ling, B., Liao, X., Huang, Y., Liang, L., Jiang, Y., Pang, Y., & Qi, G. (2020). Identification of prognostic markers of lung cancer through bioinformatics analysis and in vitro experiments. International journal of oncology, 56(1), 193-205. https://doi.org/10.3892/ijo.2019.4926
[27] Gobbi, G., Donati, B., Do Valle, I. F., Reggiani, F., Torricelli, F., Remondini, D., ... & Sancisi, V. (2019). The Hippo pathway modulates resistance to BET proteins inhibitors in lung cancer cells. Oncogene, 38(42), 6801-6817. https://doi.org/10.1038/s41388-019-0924-1
[28] Zaravinos, A., Lambrou, G. I., Boulalas, I., Delakas, D., & Spandidos, D. A. (2011). Identification of common differentially expressed genes in urinary bladder cancer. PloS one, 6(4), e18135. https://doi.org/10.1371/journal.pone.0018135
[29] Thole, T. M., Lodrini, M., Fabian, J., Wuenschel, J., Pfeil, S., Hielscher, T., ... & Deubzer, H. E. (2017). Neuroblastoma cells depend on HDAC11 for mitotic cell cycle progression and survival. Cell death & disease, 8(3), e2635-e2635. https://doi.org/10.1038/cddis.2017.49
[30] Chen, Q., Zhao, H., & Hu, J. (2023). A robust six-gene prognostic signature based on two prognostic subtypes constructed by chromatin regulators is correlated with immunological features and therapeutic response in lung adenocarcinoma. Aging (Albany NY), 15(21), 12330. https://doi.org/10.18632%2Faging.205183
[31] Li, L., & Ran, J. (2024). Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins. Cell Death & Disease, 15(1), 47. https://doi.org/10.1038/s41419-024-06428-9
[32] Yang, Y., Gao, L., Weng, N. N., Li, J. J., Liu, J. L., Zhou, Y., ... & Zhu, Q. (2021). Identification of novel molecular therapeutic targets and their potential prognostic biomarkers among kinesin superfamily of proteins in pancreatic ductal adenocarcinoma. Frontiers in Oncology, 11, 708900. https://doi.org/10.3389/fonc.2021.708900
[33] Basavarajappa, H. D., & Corson, T. W. (2012). KIF14 as an oncogene in retinoblastoma: a target for novel therapeutics?. Future medicinal chemistry, 4(17), 2149-2152. https://doi.org/10.4155/fmc.12.158
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[35] Vives-Usano, M., García Pelaez, B., Román Lladó, R., Garzón Ibañez, M., Aldeguer, E., Rodriguez, S., ... & Mayo de las Casas, C. (2021). Analysis of copy number variations in solid tumors using a next generation sequencing custom panel. Journal of Molecular Pathology, 2(2), 123-134. https://doi.org/10.3390/jmp2020013
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Published
2024-03-30
How to Cite
Vimalraj Thangaraja, Vijay Krishnan, Sivakumar Murugesan, Shahid S. Siddiqui, & Sivakumar Loganathan. (2024). Meta-Analysis of Motor Protein KIF14 with Reference to Cancer. Revista Electronica De Veterinaria, 25(1), 4286-4305. https://doi.org/10.69980/redvet.v25i1.2213
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