Ayurvedic Perspectives on Gut Microbiome Dynamics through the Trayoupastambha perspective
Abstract
The gut microbiome is a living ecosystem of bacteria, fungus, viruses, and protozoa that is very important for digestion, making nutrients, controlling the immune system, and fighting off germs. Its equilibrium promotes physiological and metabolic processes while also influencing mental health via the gut-brain axis. Diet continues to be the key determinant of microbial diversity; diets high in fiber, fruits, vegetables, and fermented preparations promote microbial resilience, while processed foods, high sugar, stress, lack of sleep, sedentary lifestyles, and drug usage lead to dysbiosis. Gut microbiota imbalances have been connected to autoimmune diseases, allergies, diabetes, gastrointestinal illnesses, and mental health issues. The three pillars of life—Ahara (diet), Nidra (sleep), and Brahmacharya (controlled lifestyle) are emphasized by Ayurveda as being essential to preserving harmony and good health. Ayurveda's ideas about personalized diets, restorative sleep, strict routines, and stress management are in sync with what we know now about microbiome science. Integrating traditional concepts with current findings provides a comprehensive framework for boosting gut health, preventing disease, and improving general well-being. By integrating modern scientific insights with traditional wisdom, we can promote gut health, enhance overall well-being, and prevent diseases linked to microbial imbalance.
References
2. Sekirov I, Russell SL, Antunes LC, Finlay BB. Gut microbiota in health and disease. Physiological Reviews. 2010;90(3):859–904.
3. Yadhava T., editor. Charaka Samhita of Agnivesha, Sootra Sthana. Ch. 11, Ver. 12. 3rd edition, Varanasi: Chaukambha Surabharati Prakashana; 2008. p.67.
4. Shivaprasad S., editor. Astanga Sangraha of Vrddha Vagbhata, Sootra Sthana. Ch. 9, Ver. 27. 4th ed. Varanasi: Choukhamba Sanskrit Series Office; 2016. 91 p.91
5. Yadhava T., editor. Charaka Samhita of Agnivesha, Sootra Sthana. Ch. 11, Verse. 12. 3rd edition, Varanasi: Chaukambha Surabharati Prakashana; 2008. p.67
6. Yadhava T.,editor. Charaka Samhita of Agnivesha, Sootra Sthana. Ch. 11, Verse. 35. 3rd edition, Varanasi: Chaukambha Surabharati Prakashana; 2008. p.74
7. Kasyapa samhita, by virddha jivaka, revised by pt. hemraja Sharma, chaukhambha Sanskrit sansthan, Varanasi, reprinted 2009, yushanirdeshya adhyaya, 4/6 page no.249.
8. Charaka samhitha. Reprint Edition 2011,. Vol. Vol-1, Sutrasthana 30/58,. Choukhambha Orientalia, Varanasi, 2014.
9. Sushruta, Sushruta Samhita, edited by Shastri Kaviraj Ambikadutta, Sutra Sthana, chapter 1, Verse No. 16, Chaukhamba Sanskrit Sansthan, Varanasi; 2007.
10. Agnivesha, Charak Samhita, with Charak Chandrika Hindi commentary, by Dr Tripathi Brahmanand and Dr Pandey Ganga Sahay, Sutra Sthana Chapter 25, Verse No. 31, Chaukhamba Surbharti Prakashan; 2007. p. 448.
11. Agnivesha, Charak Samhita, with Charak Chandrika, Hindi commentary, by Dr Tripathi Brahmanand and Dr Pandey Ganga Sahay Nidan Sthana Chapter 6, Verse No. 11, Chaukhamba Surbharti Prakashan; 2007. p. 635
12. Dwivedi, L. (ed.), Charak Samhita, Commentary of Chakrapani, Chikitsasthana, Chap 15, Verse 5, Chaukhambha Prakashana, Varanasi, 2013, 1st edn, p. 510. Charak Samhita, Commentary of Chakrapani. 2018th ed. Varanasi: Chaukhambha krishnadas academy; 510 p. (chikitsa sthanam).
13. Acharya Charaka, Vd. Yadavji Trikamji Acharya, Charak Samhita by Agnivesh with Ayurveda Dipika Commentary of Chakrapanidatta, Chaukhamba Surbharti Prakashan Varanasi, Third Edition, 2020; 236, Chapter1, Vimansthan Rasviman Adhyaya, Shlok no- 22.
14. Charaka Samhita, Vimanasthana, Chapter 1, Shloka 24. In: Shastri K, Chaturvedi G, editors. Charaka Samhita of Agnivesha revised by Charaka and Dridhabala with Ayurveda Dipika commentary of Chakrapanidatta. Varanasi: Chaukhambha Bharati Academy; 2017. p. 678.
15. Agnivesha, Charak Samhita, with Charak Chandrika Hindi commentary, by Dr Tripathi Brahmanand and Dr Pandey Ganga Sahay, Sutra Sthana Chapter 11, Verse No. 34, Chaukhamba Surbharti Prakashan; 2007. p. 238.
16. Vaidya Jadavji Trikamji. susrutha samhita with Nibanda Sangraha commentary of Dalhana Acharya (Jejjata). Sharira sthana; Chapter 4; verse 33. 8th ed. Varanasi: Choukhambha Orientalia, Varanasi, 2014.
17. Sharma R. Caraka Samhita Cakrapani Ayurveda Deepika. Sutra 21/35, 1st ed. Varanasi: Choukhambha Sanskrit Samsthan. 2012; 1:381.
18. Kaviraja Dr. Ambika dutta shashtri, Sushruta Samhita of Maharsi Sushruta, Part –I, Sutra sthana Ch.4, Verse.32, Varanasi, Chaukhamba Sanskrit Sansthaan, 2001, page 34.
19. Illustrated Ashtang Hrdaya(Text with English Translation & Appendices) by Dr. R Vaidyanath,2021 Edition,Chaukhamba Surbharati Prakashan,[A.H.Su.7/53], Pg-148
20. Jadavaji T., editor. Sushruta Samhita of Sushruta, Sootra Sthana. Ch. 2 Ver. 6. 9th edition, Varanasi: Chaukambha oriental; 2007. p.11.
21. Dr Bhakara Govind Ghanekar, Vaidyakiya Subhashit Sahityam, Chaukhambha Prakashan, Reprinted 2016, P-131.
22. Leonard JM, Del Toro D. Defining the microbiome components (bacteria, viruses, fungi) and microbiome geodiversity. mSystems. 2023;8(2):e01040-22. PMID: 37010972; PMCID: PMC10061322.
23. Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, et al. Enterotypes of the human gut microbiome. Nature. 2011;473(7346):174–180. doi:10.1038/nature09944.
24. Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol. 2011 Apr;9(4):244–253. doi:10.1038/nrmicro2537. PMID: 21407241; PMCID: PMC3535073.
25. Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI. Human nutrition, the gut microbiome and the immune system. Nature. 2011 Jun 15;474(7351):327–36. doi:10.1038/nature10213.
26. Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Cell. 2014 Mar 27;157(1):121–41. doi:10.1016/j.cell.2014.03.011.
27. Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci. 2012 Oct;13(10):701–12. doi:10.1038/nrn3346.
28. Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11971–5. doi:10.1073/pnas.1002601107.
29. David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505(7484):559–63.
30. Wen L, Duffy A. Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes. J Nutr. 2017 Jul;147(7):1468S-1475S.
31. Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A. 2007;104(34):13780–5.
32. Wang X, Guo Q, Liu Z, Wang Y, Cao C, Jin L, et al. Alterations in the Gut Microbiota Composition in Obesity with and without Type 2 Diabetes: A Pilot Study. Diabetes Metab Syndr Obes. 2024;17:3965-74.
33. L, Popa-Wagner A, Mogoşanu AD, et al. A Review of Gut Microbiota Association With Neurological and Psychiatric Disorders: What Do We Know So Far? Frontiers in Cellular and Infection Microbiology. 2022;12:813204.
34. Sorboni SG, Rahimi VB, Mohammadi Bavarsad M, Ebrahimpour S, Mirzaei H. A comprehensive review on the role of the gut microbiome in human health. Frontiers in Cellular and Infection Microbiology. 2022;12:8729913.
35. Hari Sadashiva Shastri Paradakara Bhishagacharya, editor. Ashtanga Hridaya (Composed by Arundatta and Hemadri), Nidanasthana, 12/01, Chaukhambha Surbharati Prakashana Varanasi; reprint 2022;249.
36. Sharma RK, Dash B. Charaka Samhita of Agnivesha: Text with English Translation & Critical Exposition based on Cakrapani Datta’s Ayurveda Dipika. Vol. II (Chikitsa Sthana). Varanasi: Chaukhambha Sanskrit Series Office; 2017. (C.Ch.15/3) p. 212.
37. Sharma RK, Dash B. Charaka Samhita of Agnivesha: Text with English Translation & Critical Exposition based on Cakrapani Datta’s Ayurveda Dipika. Vol. II (Chikitsa Sthana). Varanasi: Chaukhambha Sanskrit Series Office; 2017. p. 212-215.
38. Gershon MD. The Second Brain: A Groundbreaking New Understanding of Nervous Disorders of the Stomach and Intestine. New York: Harper Perennial; 1999.
39. Murthy KRS, editor. Sushruta Samhita with English Translation. Vol. I (Sutra Sthana). Varanasi: Chaukhambha Orientalia; 2012. p. 137-139.
40. Murthy KRS, editor. Sushruta Samhita with English Translation. Vol. I (Sutra Sthana). Varanasi: Chaukhambha Orientalia; 2012. p. 137-139.
41. Sharma P. Dhanvantari Nighantu. 1st ed. Varanasi: Chaukhambha Prakashan; 2009. p. 206, Ch. 6, verse 206.
42. Sourabh Gupta. Role of Takra (Ayurvedic Probiotic) in the Management of Gastrointestinal Disorders. International Journal of Research in AYUSH and Pharmaceutical Sciences. 2021;5(4):529-35.
43. Tillisch K, Labus J, Kilpatrick L, Jiang Z, Stains J, Ebrat B, et al. Consumption of a fermented milk product with probiotic modulates brain activity. Gastroenterology. 2013;144(7):1394–1401.e4
44. Sharma PV, editor. Charaka Samhita of Agnivesha: Text with English Translation. Vimana Sthana, Chapter 2, Verse 9. Varanasi: Chaukhambha Orientalia; 2014.
45. Sharma PV, editor. Charaka Samhita of Agnivesha: Text with English Translation. Sutra Sthana, Chapter 28, Verse 41. Varanasi: Chaukhambha Orientalia; 2014
46. Sharma PV, editor. Charaka Samhita of Agnivesha: Text with English Translation. Vimana Sthana, Chapter 2, Verse 8. Varanasi: Chaukhambha Orientalia; 2014.
47. Shastri AD, editor. Sushruta Samhita of Sushruta with Ayurveda-Tattva-Sandipika Commentary. Sutra Sthana, Chapter 35, Verse 29. Varanasi: Chaukhambha Sanskrit Sansthan; 2012.
48. Sharma PV, editor. Charaka Samhita of Agnivesha: Text with English Translation. Sutra Sthana, Chapter 7, Verse 40. Varanasi: Chaukhambha Orientalia; 2014.
49. Shanahan F (2005) Physiological basis for novel drug therapies used to treat the inflammatory bowel diseases. I. Pathophysiological basis and prospects for probiotic therapy in inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol 288: G417–G421