An Extensive Analysis Of The Advantages Of Curcumin For The Treatment Of Viral Infections And Abnormal Blood Disorders: A Review
Keywords:
curcumin, blood diseases, viral infectious diseases.
Abstract
The primary active ingredient in turmeric extracts is curcumin. Naturally occurring in plants, curcumin has drawn a lot of interest as a dietary supplement due to its apparent efficacy in treating a variety of human medical disorders. Curcumin exhibits pharmacological properties that are anti-inflammatory and antioxidative, as well as immunological modulation and anticancer properties, all of which are generally good for human health. We provide an overview of the current developments on curcumin as a biologically active agent in viral infectious illnesses and haematological disorders in this review article.
References
1. Esatbeyoglu T., Huebbe P., Ernst I.M.A., Chin D., Wagner A.E., Rimbach G. Curcumin--from molecule to biological function. Angew. Chem. Int. Ed. Engl. 2012.
2. Qi Y., Zhang H.B., Guo H. Research progress of turmeric and prediction analysis of quality marker (Q-Marker) Chin. Herb. Med. 2021.
3. Vallée A., Lecarpentier Y. Curcumin and Endometriosis. Int. J. Mol. Sci. 2020.
4. Abrahams S., Haylett W.L., Johnson G., Carr J.A., Bardien S. Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review. Neuroscience. 2019.
5. Giordano A., Tommonaro G. Curcumin and Cancer. Nutrients. 2019.
6. Yang M., Akbar U., Mohan C. Curcumin in Autoimmune and Rheumatic Diseases. Nutrients. 2019.
7. H. Lodish, A. Berk, S.L. Zipursky, P. Matsudaira, D. Baltimore, J. Darnell, Molecular Cell Biology. 4 ed., W.H. Freeman & Co. Ltd, New York, 2000.
8. Boggian K., Piffaretti J.C., Hirschel B., Janin P., Francioli P., Flepp M., Telenti A. Clinical progression, survival, and 8. Greub G., Ledergerber B., Battegay M., Grob P., Perrin L., Furrer H., Burgisser P., Erb P., immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: the Swiss HIV cohort study. Lancet. 2000;356(9244):1800–1805. doi: 10.1016/s0140-6736(00)032323 [PubMed] [CrossRef] [Google Scholar] [Ref list]
9. CDC, HIV/AIDs Surveillance Report, US Department of Health and Human Services, Public Health Service . Center for Infectious Diseases; Division of HIV/AIDS: 1990. Centers for Disease Control; pp. 1–18. [Google Scholar] [Ref list]
10 A.S. Evans, Viral Infections of Humans: Epidemiology and Control, 3 ed., Springer Science & Business Media2013.
11. Fenner F., Bachmann P.A., Gibbs E.P.J., Murphy F.A., Studdert M.J., White D.O. Viral replication. Veterinary Virology. 1987:55–88. doi: 10.1016/B978-0-12-253055-5.500086 [CrossRef] [Google Scholar]
12. A., Pilankatta R., Teramoto T., Sajith A.M., Nwulia E., Kulkarni A., Padmanabhan R. Inhibition of dengue virus by curcuminoids. Antivir. Res. 2019;162:71–78. doi: 10.1016/j.antiviral.2018.12.002. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
13 . Jeong E.-H., Vaidya B., Cho S.-Y., Park M.-A., Kaewintajuk K., Kim S.R., Oh M.-J., Choi J.-S., Kwon J., Kim D. Identification of regulators of the early stage of viral hemorrhagic septicemia virus infection during curcumin treatment. Fish Shellfish Immunol. 2015;45:184–193. doi: 10.1016/j.fsi.2015.03.042. [PubMed] [CrossRef] [Google Scholar]
14 Ferreira V.H., Nazli A., Dizzell S.E., Mueller K., Kaushic C. The anti-inflammatory activity of curcumin protects the genital mucosal epithelial barrier from disruption and blocks replication of HIV-1 and HSV-2. PLoS ONE. 2015;10:e0124903. doi: 10.1371/journal.pone.0124903. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
15. Li H., Zhong C., Wang Q., Chen W., Yuan Y. Curcumin is an APE1 redox inhibitor and exhibits an antiviral activity against KSHV replication and pathogenesis. Antivir. Res. 2019;167:98–103. doi: 10.1016/j.antiviral.2019.04.011. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
16. Lin C.-J., Chang L., Chu H.-W., Lin H.-J., Chang P.-C., Wang R.Y.L., Unnikrishnan B., Mao J.-Y., Chen S.-Y., Huang C.-C. High Amplification of the Antiviral Activity of Curcumin through Transformation into Carbon Quantum Dots. Small. 2019;15:1902641. doi: 10.1002/smll.201902641. [PubMed] [CrossRef] [Google Scholar]
17. Dai J., Gu L., Su Y., Wang Q., Zhao Y., Chen X., Deng H., Li W., Wang G., Li K. Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2/4, p38/JNK MAPK and NF-κB pathways. Int. Immunopharmacol. 2018;54:177–187. doi: 10.1016/j.intimp.2017.11.009. [PubMed] [CrossRef] [Google Scholar]
18. Wu J., Hou W., Cao B., Zuo T., Xue C., Leung A.W., Xu C., Tang Q.J. Virucidal efficacy of treatment with photodynamically activated curcumin on murine norovirus bio-accumulated in oysters. Photodiagnosis Photodyn. Ther. 2015;12:385–392. doi: 10.1016/j.pdpdt.2015.06.005. [PubMed] [CrossRef] [Google Scholar]
19. Du T., Shi Y., Xiao S., Li N., Zhao Q., Zhang A., Nan Y., Mu Y., Sun Y., Wu C., et al. Curcumin is a promising inhibitor of genotype 2 porcine reproductive and respiratory syndrome virus infection. BMC Vet. Res. 2017;13:298. doi: 10.1186/s12917-017-1218-x. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
20. Ali A., Banerjea A.C. Curcumin inhibits HIV-1 by promoting Tat protein degradation. Sci. Rep. 2016;6:27539. doi: 10.1038/srep27539. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
21 Sathyapalan T, Atkin SL. Is there a role for immune and anti-in-flammatory therapy in type 2 diabetes? Minerva Endocrinol. 2011;36(2):147–156. [PubMed] [Google Scholar]
22. Srinivasan M. Effect of curcumin on blood sugar as seen in a diabetic subject. Indian J Med Sci. 1972;26(4):269–270. [PubMed] [Google Scholar]
23. Dyslipidaemia. Durrington P. Lancet. 2003;12:717–731. [PubMed] [Google Scholar] [Ref list]
24. Monogenic hypercholesterolemia: new insights in pathogenesis and treatment. Rader DJ, Cohen J, Hobbs HH. J Clin Investig. 2003;6:1795–1803. [PMC free article] [PubMed] [Google Scholar]
25 Muralidar S., Ambi S.V., Sekaran S., Krishnan U.M. The emergence of COVID-19 as a global pandemic: Understanding the epidemiology, immune response and potential therapeutic targets of SARS-CoV-2. Biochimie. 2020.
26 Wu C.H. Master’s Thesis. Guangzhou University of Chinese Medicine; Guangzhou, China: 2021. Inhibition of SARS-CoV-2 Infection by Extracellular Vesicles and the Effect of Curcumin on Extracellular Vesicles.
27 Li Y., Wang J., Liu Y., Luo X., Lei W., Xie L. Antiviral and virucidal effects of curcumin on transmissible gastroenteritis virus in vitro. J. Gen. Virol. 2020.
28. Liu Ni Meng Y.R., Zhang J.L., Zhu Y.T., Huang Z.C. Experimental study of curcumin against influenza viruses H1N1 and H3N2 in vitro. Zhejiang J. Integr. Tradit. Chin. West. Med. 2008.
29. Balasubramanyam K., Varier R.A., Altaf M., Swaminathan V., Siddappa N.B., Ranga U., Kundu T.K. Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. J. Biol. Chem. 2004.
30. Si X., Wang Y., Wong J., Zhang J., McManus B.M., Luo H. Dysregulation of the ubiquitin-proteasome system by curcumin suppresses coxsackievirus B3 replication. J. Virol. 2007.
31. Wei Z., Zhang Y., Ke C., Chen H., Ren P., He Y., Hu P., Ma D., Luo J., Meng Z. Curcumin inhibits hepatitis B virus infection by down-regulating cccDNA-bound histone acetylation. World J. Gastroenterol. 2017
32. Chen M.H., Lee M.Y., Chuang J.J., Li Y.Z., Ning S.T., Chen J.C., Liu Y.W. Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT. Int. J. Mol. Med. 2012.
33. Mishra A., Kumar R., Tyagi A., Kohaar I., Hedau S., Bharti A.C., Sarker S., Dey D., Saluja D., Das B. Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer. Ecancermedicalscience. 2015.
34. Šudomová M., Hassan S. Nutrace utical Curcumin with Promising Protection against Herpesvirus Infections and Their Associated Inflammation: Mechanisms and Pathways. Microorganisms. 2021.
35. Kutluay S.B., Doroghazi J., Roemer M.E., Triezenberg S.J. Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity. Virology. 2008.
36. Chen T.-Y., Chen D.-Y., Wen H.-W., Ou J.-L., Chiou S.-S., Chen J.-M., Wong M.-L., Hsu W.-L. Inhibition of enveloped viruses infectivity by curcumin. PLoS ONE. 2013.
37. Qin S., Huang L., Gong J., Huang J., Ren H., Hu H. Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: A meta-analysis of randomized controlled trials. Nutr. J. 2017.
38. Zou J., Zhang S., Li P., Zheng X., Feng D. Supplementation with curcumin inhibits intestinal cholesterol absorption and prevents atherosclerosis in high-fat diet–fed apolipoprotein E knockout mice. Nutr. Res. 2018.
39. Kim M., Kim Y. Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet. Nutr. Res. Pract. 2010.
40. Fan A.Y., Wu X.J., Shao A.M., Chen G. Effects of curcumin on blood lipid, inflammatory factors and endothelial function in atherosclerotic rabbits. Sci. Technol. Tradit. Chin. Med. 2020.
41. Zhang T., He Q., Liu Y., Chen Z., Hu H. Efficacy and Safety of Curcumin Supplement on Improvement of Insulin Resistance in People with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evid.-Based Complement. Altern. Med.2021.
42 Zhu Y.J., Cheng J.L., Gao Z.G., Cui X., Li X.C., Chang B.C. Curcumin promotes skeletal muscle GLUT4 translocation and improves insulin resistance in diabetic rats. Chin. J. Endocrinol. Metab. 2021.
43. Du G.H., Liu B.W., Yin F.Z., Qi X.M., Fan D.M. Effect of liraglutide on the expression and mechanism of liver glycosuria key enzymes PEPCK and G6pase in diabetic mice. Chin. J. Comp. Med. 2020.
44. Qian W.L., Gao X.B., Yu Z.W., Nan L.H. Study on the improvement effect and mechanism of curcumin central administration on insulin resistance mice. Fujian Tradit. Chin. Med. 2019.
45. Radomska-Leśniewska D.M., Osiecka-Iwan A., Hyc A., Góźdź A., Dąbrowska A.M., Skopiński P. Therapeutic potential of curcumin in eye diseases. Cent. Eur. J. Immunol. 2019.
46. Boarescu P.M., Boarescu I., Bocșan I.C., Gheban D., Bulboacă A.E., Nicula C., Pop R.M., Râjnoveanu R.-M., Bolboacă S.D. Antioxidant and Anti-Inflammatory Effects of Curcumin Nanoparticles on Drug-Induced Acute Myocardial Infarction in Diabetic Rats. Antioxidants.2019.
47. Keihanian F., Saeidinia A., Bagheri R.K., Johnston T.P., Sahebkar A. Curcumin, hemostasis, thrombosis, and coagulation. J. Cell Physiol. 2018.
2. Qi Y., Zhang H.B., Guo H. Research progress of turmeric and prediction analysis of quality marker (Q-Marker) Chin. Herb. Med. 2021.
3. Vallée A., Lecarpentier Y. Curcumin and Endometriosis. Int. J. Mol. Sci. 2020.
4. Abrahams S., Haylett W.L., Johnson G., Carr J.A., Bardien S. Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review. Neuroscience. 2019.
5. Giordano A., Tommonaro G. Curcumin and Cancer. Nutrients. 2019.
6. Yang M., Akbar U., Mohan C. Curcumin in Autoimmune and Rheumatic Diseases. Nutrients. 2019.
7. H. Lodish, A. Berk, S.L. Zipursky, P. Matsudaira, D. Baltimore, J. Darnell, Molecular Cell Biology. 4 ed., W.H. Freeman & Co. Ltd, New York, 2000.
8. Boggian K., Piffaretti J.C., Hirschel B., Janin P., Francioli P., Flepp M., Telenti A. Clinical progression, survival, and 8. Greub G., Ledergerber B., Battegay M., Grob P., Perrin L., Furrer H., Burgisser P., Erb P., immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: the Swiss HIV cohort study. Lancet. 2000;356(9244):1800–1805. doi: 10.1016/s0140-6736(00)032323 [PubMed] [CrossRef] [Google Scholar] [Ref list]
9. CDC, HIV/AIDs Surveillance Report, US Department of Health and Human Services, Public Health Service . Center for Infectious Diseases; Division of HIV/AIDS: 1990. Centers for Disease Control; pp. 1–18. [Google Scholar] [Ref list]
10 A.S. Evans, Viral Infections of Humans: Epidemiology and Control, 3 ed., Springer Science & Business Media2013.
11. Fenner F., Bachmann P.A., Gibbs E.P.J., Murphy F.A., Studdert M.J., White D.O. Viral replication. Veterinary Virology. 1987:55–88. doi: 10.1016/B978-0-12-253055-5.500086 [CrossRef] [Google Scholar]
12. A., Pilankatta R., Teramoto T., Sajith A.M., Nwulia E., Kulkarni A., Padmanabhan R. Inhibition of dengue virus by curcuminoids. Antivir. Res. 2019;162:71–78. doi: 10.1016/j.antiviral.2018.12.002. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
13 . Jeong E.-H., Vaidya B., Cho S.-Y., Park M.-A., Kaewintajuk K., Kim S.R., Oh M.-J., Choi J.-S., Kwon J., Kim D. Identification of regulators of the early stage of viral hemorrhagic septicemia virus infection during curcumin treatment. Fish Shellfish Immunol. 2015;45:184–193. doi: 10.1016/j.fsi.2015.03.042. [PubMed] [CrossRef] [Google Scholar]
14 Ferreira V.H., Nazli A., Dizzell S.E., Mueller K., Kaushic C. The anti-inflammatory activity of curcumin protects the genital mucosal epithelial barrier from disruption and blocks replication of HIV-1 and HSV-2. PLoS ONE. 2015;10:e0124903. doi: 10.1371/journal.pone.0124903. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
15. Li H., Zhong C., Wang Q., Chen W., Yuan Y. Curcumin is an APE1 redox inhibitor and exhibits an antiviral activity against KSHV replication and pathogenesis. Antivir. Res. 2019;167:98–103. doi: 10.1016/j.antiviral.2019.04.011. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
16. Lin C.-J., Chang L., Chu H.-W., Lin H.-J., Chang P.-C., Wang R.Y.L., Unnikrishnan B., Mao J.-Y., Chen S.-Y., Huang C.-C. High Amplification of the Antiviral Activity of Curcumin through Transformation into Carbon Quantum Dots. Small. 2019;15:1902641. doi: 10.1002/smll.201902641. [PubMed] [CrossRef] [Google Scholar]
17. Dai J., Gu L., Su Y., Wang Q., Zhao Y., Chen X., Deng H., Li W., Wang G., Li K. Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2/4, p38/JNK MAPK and NF-κB pathways. Int. Immunopharmacol. 2018;54:177–187. doi: 10.1016/j.intimp.2017.11.009. [PubMed] [CrossRef] [Google Scholar]
18. Wu J., Hou W., Cao B., Zuo T., Xue C., Leung A.W., Xu C., Tang Q.J. Virucidal efficacy of treatment with photodynamically activated curcumin on murine norovirus bio-accumulated in oysters. Photodiagnosis Photodyn. Ther. 2015;12:385–392. doi: 10.1016/j.pdpdt.2015.06.005. [PubMed] [CrossRef] [Google Scholar]
19. Du T., Shi Y., Xiao S., Li N., Zhao Q., Zhang A., Nan Y., Mu Y., Sun Y., Wu C., et al. Curcumin is a promising inhibitor of genotype 2 porcine reproductive and respiratory syndrome virus infection. BMC Vet. Res. 2017;13:298. doi: 10.1186/s12917-017-1218-x. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
20. Ali A., Banerjea A.C. Curcumin inhibits HIV-1 by promoting Tat protein degradation. Sci. Rep. 2016;6:27539. doi: 10.1038/srep27539. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
21 Sathyapalan T, Atkin SL. Is there a role for immune and anti-in-flammatory therapy in type 2 diabetes? Minerva Endocrinol. 2011;36(2):147–156. [PubMed] [Google Scholar]
22. Srinivasan M. Effect of curcumin on blood sugar as seen in a diabetic subject. Indian J Med Sci. 1972;26(4):269–270. [PubMed] [Google Scholar]
23. Dyslipidaemia. Durrington P. Lancet. 2003;12:717–731. [PubMed] [Google Scholar] [Ref list]
24. Monogenic hypercholesterolemia: new insights in pathogenesis and treatment. Rader DJ, Cohen J, Hobbs HH. J Clin Investig. 2003;6:1795–1803. [PMC free article] [PubMed] [Google Scholar]
25 Muralidar S., Ambi S.V., Sekaran S., Krishnan U.M. The emergence of COVID-19 as a global pandemic: Understanding the epidemiology, immune response and potential therapeutic targets of SARS-CoV-2. Biochimie. 2020.
26 Wu C.H. Master’s Thesis. Guangzhou University of Chinese Medicine; Guangzhou, China: 2021. Inhibition of SARS-CoV-2 Infection by Extracellular Vesicles and the Effect of Curcumin on Extracellular Vesicles.
27 Li Y., Wang J., Liu Y., Luo X., Lei W., Xie L. Antiviral and virucidal effects of curcumin on transmissible gastroenteritis virus in vitro. J. Gen. Virol. 2020.
28. Liu Ni Meng Y.R., Zhang J.L., Zhu Y.T., Huang Z.C. Experimental study of curcumin against influenza viruses H1N1 and H3N2 in vitro. Zhejiang J. Integr. Tradit. Chin. West. Med. 2008.
29. Balasubramanyam K., Varier R.A., Altaf M., Swaminathan V., Siddappa N.B., Ranga U., Kundu T.K. Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. J. Biol. Chem. 2004.
30. Si X., Wang Y., Wong J., Zhang J., McManus B.M., Luo H. Dysregulation of the ubiquitin-proteasome system by curcumin suppresses coxsackievirus B3 replication. J. Virol. 2007.
31. Wei Z., Zhang Y., Ke C., Chen H., Ren P., He Y., Hu P., Ma D., Luo J., Meng Z. Curcumin inhibits hepatitis B virus infection by down-regulating cccDNA-bound histone acetylation. World J. Gastroenterol. 2017
32. Chen M.H., Lee M.Y., Chuang J.J., Li Y.Z., Ning S.T., Chen J.C., Liu Y.W. Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT. Int. J. Mol. Med. 2012.
33. Mishra A., Kumar R., Tyagi A., Kohaar I., Hedau S., Bharti A.C., Sarker S., Dey D., Saluja D., Das B. Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer. Ecancermedicalscience. 2015.
34. Šudomová M., Hassan S. Nutrace utical Curcumin with Promising Protection against Herpesvirus Infections and Their Associated Inflammation: Mechanisms and Pathways. Microorganisms. 2021.
35. Kutluay S.B., Doroghazi J., Roemer M.E., Triezenberg S.J. Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity. Virology. 2008.
36. Chen T.-Y., Chen D.-Y., Wen H.-W., Ou J.-L., Chiou S.-S., Chen J.-M., Wong M.-L., Hsu W.-L. Inhibition of enveloped viruses infectivity by curcumin. PLoS ONE. 2013.
37. Qin S., Huang L., Gong J., Huang J., Ren H., Hu H. Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: A meta-analysis of randomized controlled trials. Nutr. J. 2017.
38. Zou J., Zhang S., Li P., Zheng X., Feng D. Supplementation with curcumin inhibits intestinal cholesterol absorption and prevents atherosclerosis in high-fat diet–fed apolipoprotein E knockout mice. Nutr. Res. 2018.
39. Kim M., Kim Y. Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet. Nutr. Res. Pract. 2010.
40. Fan A.Y., Wu X.J., Shao A.M., Chen G. Effects of curcumin on blood lipid, inflammatory factors and endothelial function in atherosclerotic rabbits. Sci. Technol. Tradit. Chin. Med. 2020.
41. Zhang T., He Q., Liu Y., Chen Z., Hu H. Efficacy and Safety of Curcumin Supplement on Improvement of Insulin Resistance in People with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evid.-Based Complement. Altern. Med.2021.
42 Zhu Y.J., Cheng J.L., Gao Z.G., Cui X., Li X.C., Chang B.C. Curcumin promotes skeletal muscle GLUT4 translocation and improves insulin resistance in diabetic rats. Chin. J. Endocrinol. Metab. 2021.
43. Du G.H., Liu B.W., Yin F.Z., Qi X.M., Fan D.M. Effect of liraglutide on the expression and mechanism of liver glycosuria key enzymes PEPCK and G6pase in diabetic mice. Chin. J. Comp. Med. 2020.
44. Qian W.L., Gao X.B., Yu Z.W., Nan L.H. Study on the improvement effect and mechanism of curcumin central administration on insulin resistance mice. Fujian Tradit. Chin. Med. 2019.
45. Radomska-Leśniewska D.M., Osiecka-Iwan A., Hyc A., Góźdź A., Dąbrowska A.M., Skopiński P. Therapeutic potential of curcumin in eye diseases. Cent. Eur. J. Immunol. 2019.
46. Boarescu P.M., Boarescu I., Bocșan I.C., Gheban D., Bulboacă A.E., Nicula C., Pop R.M., Râjnoveanu R.-M., Bolboacă S.D. Antioxidant and Anti-Inflammatory Effects of Curcumin Nanoparticles on Drug-Induced Acute Myocardial Infarction in Diabetic Rats. Antioxidants.2019.
47. Keihanian F., Saeidinia A., Bagheri R.K., Johnston T.P., Sahebkar A. Curcumin, hemostasis, thrombosis, and coagulation. J. Cell Physiol. 2018.
Published
2024-03-12
How to Cite
Krishma Kumari, Deepshikha, Dr. Asha Gandhi, Ranju Marwaha, Amanjeet Singh, & Rubal. (2024). An Extensive Analysis Of The Advantages Of Curcumin For The Treatment Of Viral Infections And Abnormal Blood Disorders: A Review. Revista Electronica De Veterinaria, 25(1), 4201-4206. https://doi.org/10.69980/redvet.v25i1.2166
Issue
Section
Articles
