An Insight On The Effects Of Lactobacillus Plantarum 299v (L. Plantarum 299v) Probiotic Supplementation Added To Oral Iron Replacement Therapy On Serum Iron Status Markers In Patients With Newly Diagnosed Iron Deficiency Anaemia : A Single-Centre Study Fr
Abstract
Anemia remains a widespread health issue globally, especially in impoverished regions where the rates are high. The condition is multifactorial, with iron deficiency being the most common. Current treatments mainly involve taking iron supplements or using drugs that stimulate red blood cell production. However, these options may not work well for everyone. Emerging research suggests that probiotics, prebiotics, and synbiotics—agents that modify the microbiome—could be valuable in treating anemia. They might help improve how the body absorbs iron and boost blood health by changing gut bacteria. These approaches could serve as alternatives or additions to traditional therapies. This study was designed to explore the impact of adding Lactobacillus plantarum 299v (L. plantarum 299v) probiotic to oral iron therapy on serum iron markers in patients newly diagnosed with iron deficiency anemia.
References
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9. Goossens D, Jonkers D, Russel M, et al. (2005) Survival of the probiotic, L. plantarum 299v and its effects on the faecal bacterial flora, with and without gastric acid inhibition. Dig Liver Dis 37, 44–50.
10. Ducrotté P, Sawant P & Jayanthi V (2012) Clinical trial: lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World J Gastroenterol 18, 4012–4018.
11. Rusu IG et al. Iron supplementation influence on the Gut Microbiota and Probiotic Intake Effect in Iron Deficiency-A Literature-based review. Nutrients, 2020. 12(7).
12. Hadadi N, et al. Intestinal microbiota as a route for micronutrient bioavailabil- ity. Curr Opin Endocr Metab Res. 2021;20:100285.
13. Husmann FMD, Zimmermann MB, Herter-Aeberli I. The Effect of Prebiotics on Human Iron absorption: a review. Adv Nutr. 2022;13(6):2296–304.
14. Axling U, Önning G, Martinsson Niskanen T, et al. (2021) The effect of Lactiplantibacillus plantarum 299v together with a low dose of iron on iron status in healthy pregnant women: a randomized clinical trial. Acta Obstet Gynecol Scand 100, 1602–1610.
15. OjiNjideka Hemphill N, Pezley L, Steffen A, et al. (2023) Feasibility study of Lactobacillus Plantarum 299v probiotic supplementation in an urban academic facility among diverse pregnant individuals. Nutrients 15, 875.
16. Chen JH, et al. Prebiotic oligosaccharides enhance Iron absorption Via Modu- lation of protein expression and gut microbiota in a dose-response manner in Iron-Deficient growing rats. Mol Nutr Food Res. 2022;66(10):e2101064.
17. Mikulic N, et al. Prebiotics increase iron absorption and reduce the adverse effects of iron on the gut microbiome and inflammation: a randomized controlled trial using iron stable isotopes in Kenyan infants. Am J Clin Nutr. 2024;119(2):456–69.
2. Stevens GA, Finucane MM, Nutrition Impact Model Study Group (Anaemia), et al. (2013) Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995–2011: a systematic analysis of population-representative data. Lancet Glob Health 1, e16–e25.
3. Kumar SB, Arnipalli SR, Mehta P, et al. (2022) Iron deficiency anemia: efficacy and limitations of nutritional and comprehensive mitigation strategies. Nutrients 14, 2976.
4. Zakrzewska Z, Zawartka A, Schab M, et al. (2022) Prebiotics, probiotics, and postbiotics in the prevention and treatment of anemia. Microorganisms 10, 1330.
5. Seo H, Yoon SY, Ul-Haq A, et al. (2023) The effects of iron deficiency on the gut microbiota in women of childbearing age. Nutrients 15, 691.
6. Rusu IG, Suharoschi R, Vodnar DC, et al. (2020) Iron supplementation influence on the gut microbiota and probiotic intake effect in iron deficiency-a literature-based review. Nutrients 12, 1993.
7. Bazeley JW & Wish JB (2022) Recent and emerging therapies for iron deficiency in anemia of CKD: a review. Am J Kidney Dis 79, 868–876.
8. Hoppe M, Önning G, Berggren A, et al. (2015) Probiotic strain lactobacillus plantarum 299v increases iron absorption from an iron-supplemented fruit drink: a double-isotope cross-over single-blind study in women of reproductive age. Br J Nutr 114, 1195–1202.
9. Goossens D, Jonkers D, Russel M, et al. (2005) Survival of the probiotic, L. plantarum 299v and its effects on the faecal bacterial flora, with and without gastric acid inhibition. Dig Liver Dis 37, 44–50.
10. Ducrotté P, Sawant P & Jayanthi V (2012) Clinical trial: lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World J Gastroenterol 18, 4012–4018.
11. Rusu IG et al. Iron supplementation influence on the Gut Microbiota and Probiotic Intake Effect in Iron Deficiency-A Literature-based review. Nutrients, 2020. 12(7).
12. Hadadi N, et al. Intestinal microbiota as a route for micronutrient bioavailabil- ity. Curr Opin Endocr Metab Res. 2021;20:100285.
13. Husmann FMD, Zimmermann MB, Herter-Aeberli I. The Effect of Prebiotics on Human Iron absorption: a review. Adv Nutr. 2022;13(6):2296–304.
14. Axling U, Önning G, Martinsson Niskanen T, et al. (2021) The effect of Lactiplantibacillus plantarum 299v together with a low dose of iron on iron status in healthy pregnant women: a randomized clinical trial. Acta Obstet Gynecol Scand 100, 1602–1610.
15. OjiNjideka Hemphill N, Pezley L, Steffen A, et al. (2023) Feasibility study of Lactobacillus Plantarum 299v probiotic supplementation in an urban academic facility among diverse pregnant individuals. Nutrients 15, 875.
16. Chen JH, et al. Prebiotic oligosaccharides enhance Iron absorption Via Modu- lation of protein expression and gut microbiota in a dose-response manner in Iron-Deficient growing rats. Mol Nutr Food Res. 2022;66(10):e2101064.
17. Mikulic N, et al. Prebiotics increase iron absorption and reduce the adverse effects of iron on the gut microbiome and inflammation: a randomized controlled trial using iron stable isotopes in Kenyan infants. Am J Clin Nutr. 2024;119(2):456–69.
Published
2024-08-20
How to Cite
Alam Saba, Banerjee Bedarshi, Chatterjee Soumik, Mandal Sriparna, & Sarkar Ranu. (2024). An Insight On The Effects Of Lactobacillus Plantarum 299v (L. Plantarum 299v) Probiotic Supplementation Added To Oral Iron Replacement Therapy On Serum Iron Status Markers In Patients With Newly Diagnosed Iron Deficiency Anaemia : A Single-Centre Study Fr. Revista Electronica De Veterinaria, 25(1), 4071-4074. https://doi.org/10.69980/redvet.v25i1.2087
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