Therapeutic Potential Of Neem (Azadirachta Indica): A Review Of Its Bioactive Compounds And Anticancer Properties.
Abstract
The neem tree, native to the Indian subcontinent, has been pivotal in traditional medicine for ages. Neem, scientifically known as Azadirachta indica, contains a multitude of useful chemicals that are being investigated for their anti-cancer properties. The anticancer properties of these drugs, highlighting their unique structural features and methods of action. Azadirachtin, once acknowledged for its pesticidal properties, has novel potential as an anti-inflammatory and anticancer drug. Phytoconstituents like Gedunin, acting as an HSP90 inhibitor, demonstrates significant effects on gastric cancer cells. Nimbin, classified as a limonoid, exhibits protective properties against oxidative stress, especially in circumstances such as polycystic ovarian syndrome. Beta-sitosterol, a triterpenoid, is examined for its capacity to induce apoptosis in several cancer cells. This review thoroughly examines their modes of action, including apoptotic induction, caspase activation, cell cycle arrest, and signaling pathway regulation, so providing a solid basis for future research and development efforts. The findings suggest that neem may serve as a viable complementary or alternative therapy in the broad field of cancer treatment. This review examines the bioactive compounds derived from the neem tree and their potential applications in cancer treatment. The focus is on its bioactive constituents, including limonoids, triterpenoids, and quinones, highlighting essential components such as azadirachtin, gedunin, nimbin, and beta-sitosterol.
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