The Effect of Vitamin C Pretreatment on Acute Nickel Nephrotoxicity in Male Mice
This study was conducted to observe the preventive effect of using vitamin C and its effects on impaired kidney function caused by the element nickel. The study included 60 laboratory rats weighing from 29 to 33 grams Among the 60 male mice, 48 adapted mice were selected from them after weighing. These 48 mice were divided into six experimental groups, each group containing eight individuals. The treatment of laboratory mice continued for 30 days. The study showed that there was a significant increase in the weights of the kidneys of rats that were injected with nickel chloride when compared to the control group and the group that was given vitamin C orally, but there were no significant differences in the weights of the kidneys of mice that were given vitamin C previously., but at the same time it occurred an increase in the concentration of uric acid, urea and creatinine in the blood of mice, and this was confirmed by changes in the tissues of the kidneys of mice but the treatment of vitamin C can protect the kidneys from these toxins substance of nickel chloride. The study concluded that treatment with vitamin C can act as antioxidant that protect kidney and hematological elements from damage.