Unraveling The Neurotherapeutic Potential of Mahakalyanaka Ghrita In Non-Motor Dimensions Of Parkinson’s Disease
Abstract
Parkinson's disease (PD) is commonly associated with motor symptoms, but Non-motor features such as cognitive decline, mood disorders, sleep disturbances, and autonomic dysfunction significantly affect patients' quality of life. These non-motor symptoms often remain underrecognized and inadequately treated. Mahakalyanaka Ghrita, an Ayurvedic formulation combining ghee with medicinal herbs, is traditionally used to address neurological disorders. This conceptual review explores the potential mode of action of Mahakalyanaka Ghrita in managing the Non-motor features of Parkinson’s disease. The ingredients in this formulation possess Neuroprotective, Anti-Anti Parkinson’s, Inflammatory, Antioxidant, and Adaptogenic properties, which may help alleviate Cognitive dysfunction, Mood disorders, Sleep disturbances, Sexual dysfunctions and Autonomic dysfunction commonly seen in PD. From an Ayurvedic perspective, Mahakalyanaka Ghrita is believed to balance tridoshas, contributing to overall Neurological and Emotional well-being. The review underscores the importance of integrating Mahakalyanaka Ghrita as an adjunct to conventional therapies, with a call for further clinical studies to validate its efficacy in managing Non-motor features of Parkinson’s disease.
References
Menon Gopinath and Menon Vijaya; Parkinson’s disease and Related Disorders- Current Concepts and Treatment; Published by G. Kamath, 1995.
Krishna Das, K.V, Textbook of medicine, (5th edition), Jaypee, 2008, SectioN- 17, Chapter-191, pg no-1258
Muniyal Y.P; Sharma S.K; Agarwal A.K; Gupta P; Kamath S.A; Nadkar M.Y; Singal R.K; Sundar S; Varma S; et al. API Textbook of Medicine (9th edition). The Association of Physicians of India, 2012, Volume 2, Section 20, Chapter 19, pg no-1460
Penman Ian D, Ralston Stuart H, Strachan Mark W. J, Hobson Richard P. Davidson’s Principles and Practice of Medicine (24th edition). Elsevier Heath Sciences.2022.Part 3, Chapter 28, Pg no-1166
Loscalzo;Fauci;Kasper;Hauser;Longo;Jameson. Harrison’s Principles of Internal Medicine (21st edition). Mc Graw Hill education, 2018.Volume 2, Part 13, Section 435, pg no- 3384
Muniyal Y.P; Sharma S.K; Agarwal A.K; Gupta P; Kamath S.A; Nadkar M.Y; Singal R.K; Sundar S; Varma S; et al. API Textbook of Medicine (9th edition). The Association of Physicians of India, 2012, Volume 2, Section 20, Chapter 19, pg no-1460.
Golwalla Aspi. F, Golwalla Sharukh.A, Nadkar Milind Y, Golwalla’s Medicine for Students, A Reference Book for Family Physician, (25th edition). Jaypee, 2017, Section 7, Chapter 20, pg no-563
Krishna Das, K.V, Textbook of medicine, (5th edition), Jaypee, 2008, Section Chapter pg no-1259.
Paul Lingor; Jan Liman; Kai Kallenberg; Carsten-Oliver Sahlmann; Mathias Bahr; research gate, diagnosis and differential diagnosis of Parkinson’s disease, chapterSeptember 2011. DOI: 10.5772/18987
He R, Yan X, Guo J, Xu Q, Tang B and Sun Q (2018) Recent Advances in Biomarkers for Parkinson’s Disease. Front. Aging Neurosci. 10:305. doi: 10.3389/fnagi.2018.00305
Krishna Das, K.V, Textbook of medicine, (5th edition), Jaypee, 2008, SectioN- 17, Chapter-191, pg no-1259
DeMaagd G, Philip A. Parkinson's Disease and Its Management: Part 1: Disease Entity, Risk Factors, Pathophysiology, Clinical Presentation, and Diagnosis. P T. 2015 Aug;40(8):504-32. PMID: 26236139; PMCID: PMC4517533.
Krishna Das, K.V, Textbook of medicine, (5th edition), Jaypee, 2008, SectioN- 17, Chapter-191, pg no-1260
Penman Ian D, Ralston Stuart H, Strachan Mark W. J, Hobson Richard P. Davidson’s Principles and Practice of Medicine (24th edition). Elsevier Heath Sciences.2022.Part 3, Chapter 28, Pg no- 1167.
Muniyal Y.P; Sharma S.K; Agarwal A.K; Gupta P; Kamath S.A; Nadkar M.Y; Singal R.K; Sundar S; Varma S; et al. API Textbook of Medicine (9th edition). The Association of Physicians of India, 2012, Volume 2, Section 20, Chapter 19, pg no-1461
Penman Ian D, Ralston Stuart H, Strachan Mark W. J, Hobson Richard P. Davidson’s Principles and Practice of Medicine (24th edition). Elsevier Heath Sciences.2022.Part 3, Chapter 28, Pg no- 1166-1167
Golwalla Aspi. F, Golwalla Sharukh.A, Nadkar Milind Y, Golwalla’s Medicine for Students, A Reference Book for Family Physician, (25th edition). Jaypee, 2017, Section 7, Chapter 20, pg no-563
Church FC. Treatment Options for Motor and Non-Motor Symptoms of Parkinson's Disease. Biomolecules. 2021 Apr 20;11(4):612. doi:10.3390/biom11040612. PMID: 33924103; PMCID: PMC8074325
Muniyal Y.P; Sharma S.K; Agarwal A.K; Gupta P; Kamath S.A; Nadkar M.Y; Singal R.K; Sundar S; Varma S; et al. API Textbook of Medicine (9th edition). The Association of Physicians of India, 2012, Volume 2, Section 20, Chapter 19, pg no-1462
Penman Ian D, Ralston Stuart H, Strachan Mark W. J, Hobson Richard P. Davidson’s Principles and Practice of Medicine (24th edition). Elsevier Heath Sciences.2022.Part 3, Chapter 28, Pg no- 1168
Pardo-Moreno T, García-Morales V, Suleiman-Martos S, Rivas-Domínguez A, Mohamed Mohamed H, Ramos-Rodríguez JJ, Melguizo-Rodríguez L, González- Acedo A. Current Treatments and New, Tentative Therapies for Parkinson's Disease. Pharmaceutics. 2023 Feb 25;15(3):770. doi: 10.3390/pharmaceutics15030770. PMID: 36986631; PMCID: PMC10051786.
Acharya Vagbhata. Acharya Harishashthri Paradakara Vaidya (ed), Astanga Hridayam with Sarvangasundara commentary by Arunadatta and Ayurveda Rasayana commentary by Hemadri, Uttarasthana;, Chapter 37 verse 25 Ayurveda rasayana commentary. Reprint edition, Varanasi: Chaukhambha Orientalia; 2019; p.916.
Das S, Bisht SS. The bioactive and therapeutic potential of Hemidesmus indicus R. Br. (Indian Sarsaparilla) root. Phytother Res. 2013 Jun;27(6):791-801. doi: 10.1002/ptr.4788. Epub 2012 Aug 8. PMID: 22887725.
Prathib B, Nikhil P Varghese, Virupaksha J. H, Kuppast I. J. A Standardized Updated Review Article of Ichnocarpus frutescens Plant. Res. J. Pharmacology & Pharmacodynamics.2017; 9(1): 31-34. doi: 10.5958/2321-5836.2017.00006.4
Fuloria S, Mehta J, Chandel A, Sekar M, Rani NNIM, Begum MY, Subramaniyan V, Chidambaram K, Thangavelu L, Nordin R, Wu YS, Sathasivam KV, Lum PT, Meenakshi DU, Kumarasamy V, Azad AK, Fuloria NK. A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin. Front Pharmacol. 2022 Mar 25;13:820806. doi: 10.3389/fphar.2022.820806. PMID: 35401176; PMCID: PMC8990857.
Sharma S, Chaitanya MVNL, Sharma S, Kumar S, Rustagi S, Singh S, Shreaz S, Rai AK, Negi R, Yadav AN. The medicinal plant Berberis aristata and its endophytes for pharmacological applications: Current research and future challenges. J App Biol Biotech. 2024;12(4):37-46. http://doi.org/10.7324/JABB.2024.167591.
Subha Rastogi, Madan Mohan Pandey, Ajay Kumar Singh Rawat, An ethnomedicinal, phytochemical and pharmacological profile of Desmodium gangeticum (L.) DC. and Desmodium adscendens (Sw.) DC.,Journal of Ethnopharmacology, Volume 136, Issue 2, 2011, Pages 283-296, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2011.04.031.
Chhipa, A.S., Baksi, R. & Nivsarkar, M. Anticancer studies on methanolic extract of aerial parts of Uraria Picta (Jacq.) DC. Futur J Pharm Sci 7, 16 (2021). https://doi.org/10.1186/s43094-020-00169-0
Desi Harneti, Unang Supratman, Phytochemistry and biological activities of Aglaia species, Phytochemistry, Volume 181, 2021, 112540, ISSN 0031-9422, https://doi.org/10.1016/j.phytochem.2020.112540.
Shilpi Pathak, Ramreddy Godela, Nardostachys jatamansi: Phytochemistry, ethnomedicinal uses, and pharmacological activities: A comprehensive review, Fitoterapia, Volume 172, 2024, 105764, ISSN 0367-326X, https://doi.org/10.1016/j.fitote.2023.105764.
Akaram M and Dubey B: A brief scientific evidence of ethnobotanical and pharmacological studies of Solanum indicum lam. Int J Pharm Sci & Res 2023; 14(1): 187-97. doi: 10.13040/IJPSR.0975-8232.14(1).187-97.
Saleem TS, Lokanath N, Prasanthi A, Madhavi M, Mallika G, Vishnu MN. Aqueous extract of Saussurea lappa root ameliorate oxidative myocardial injury induced by isoproterenol in rats. J Adv Pharm Technol Res. 2013 Apr;4(2):94-100. doi: 10.4103/2231-4040.111525. PMID: 23833749; PMCID: PMC3696228.
Wen M, Chen Q, Chen W, Yang J, Zhou X, Zhang C, Wu A, Lai J, Chen J, Mei Q, Yang S, Lan C, Wu J, Huang F, Wang L. A comprehensive review of Rubia cordifolia L.: Traditional uses, phytochemistry, pharmacological activities, and clinical applications. Front Pharmacol. 2022 Sep 9;13:965390. doi: 10.3389/fphar.2022.965390. PMID: 36160419; PMCID: PMC9500525.
Dipankar Chakraborty, Paroma Arefin, Sreebash Chandra Bhattacharjee, Mehedi Hasan, Rajib Sarkar, Suman Das, Saidur Rahman, Md Shehan Habib, Shirmin Islam, Ferdoushi Jahan, Gorungo Ray, Jannatul Ferdous, Fahima Farhana, Md Ashraful Islam, Mohammad Mostafa, Biological activity of Mesua ferrea (Nageswar) seed extracts: An in vitro and in silico study, Informatics in Medicine Unlocked, Volume 36, 2023,101166, ISSN 2352-9148, https://doi.org/10.1016/j.imu.2023.101166.
Radhika rani V & Gopikrishna.S: A review on the role of Dadima (punica granatum.linn) in Hridroga chikitsa . International Ayurvedic Medical Journal {online} 2022 {cited July 2022} Available from: http://www.iamj.in/posts/images/upload/1903_1907.
Vaishnavi M. Walhekar, Vaishnavi Bathe, Vaishali Kadam, Shital Rokade, Review On Embelia Ribes And It’s Pharmacological Activity, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 4, 1312-1319. https://doi.org/10.5281/zenodo.11092906
Ghosh AK, Sen D, Bhattacharya S. A new alkaloid isolated from Abies webbiana leaf. Pharmacognosy Res. 2010 May;2(3):186-9. doi: 10.4103/0974-8490.65516. PMID: 21808564; PMCID: PMC3141312.
Yahyazadeh R, Ghasemzadeh Rahbardar M, Razavi BM, Karimi G, Hosseinzadeh H. The effect of Elettaria cardamomum (cardamom) on the metabolic syndrome: Narrative review. Iran J Basic Med Sci. 2021 Nov;24(11):1462-1469. doi: 10.22038/IJBMS.2021.54417.12228. PMID: 35317114; PMCID: PMC8917848.
Balkrishna A, Rohela A, Kumar A, Kumar A, Arya V, Thakur P, Oleksak P, Krejcar O, Verma R, Kumar D, Kuca K. Mechanistic Insight into Antimicrobial and Antioxidant Potential of Jasminum Species: A Herbal Approach for Disease Management. Plants (Basel). 2021 May 28;10(6):1089. doi: 10.3390/plants10061089. PMID: 34071621; PMCID: PMC8227019.
Raja MK, Sethiya NK, Mishra SH. A comprehensive review on Nymphaea stellata: A traditionally used bitter. J Adv Pharm Technol Res. 2010 Jul;1(3):311-9. doi: 10.4103/0110-5558.72424. PMID: 22247863; PMCID: PMC3255414.
Agrawal S, Kumar A, Kumar Singh A, Singh H, Thareja S, Kumar P. A comprehensive review on pharmacognosy, phytochemistry and pharmacological activities of 8 potent species of southeast Asia. J Tradit Chin Med. 2024 Jun;44(3):620-628. doi: 10.19852/j.cnki.jtcm.2024.03.002. PMID: 38767647; PMCID: PMC11077151.
Pipatrattanaseree, W., Itharat, A., Mukkasombut, N. et al. Potential in vitro anti-allergic, anti-inflammatory and cytotoxic activities of ethanolic extract of Baliospermum montanum root, its major components and a validated HPLC method. BMC Complement Altern Med 19, 45 (2019). https://doi.org/10.1186/s12906-019-2449-0
Sun SS, Chen XM, Guo SX. Analysis of endophytic fungi in roots of Santalum album Linn. and its host plant Kuhnia rosmarinifolia Vent. J Zhejiang Univ Sci B. 2014 Feb;15(2):109-15. doi: 10.1631/jzus.B1300011. PMID: 24510703; PMCID: PMC3924386.
Shreyasi Majumdar, Smriti Gupta, Santosh Kumar Prajapati, Sairam Krishnamurthy, Neuro-nutraceutical potential of Asparagus racemosus: A review, Neurochemistry International, Volume 145, 2021,105013, ISSN 0197-0186, https://doi.org/10.1016/j.neuint.2021.105013.
Suyal R, Jugran AK, Rawal RS, Bhatt ID. Morphological, phytochemical and genetic diversity of threatened Polygonatum verticillatum (L.) All. populations of different altitudes and habitat types in Himalayan region. Physiol Mol Biol Plants. 2021 Aug;27(8):1795-1809. doi: 10.1007/s12298-021-01044-9. Epub 2021 Aug 12. PMID: 34539117; PMCID: PMC8405746.
Liao PH, Li DL, Tong HY. The complete chloroplast genome of Polygonatum cirrhifolium (Wall.) Royle, a medicine herb. Mitochondrial DNA B Resour. 2021 Jan 17;6(1):180-181. doi: 10.1080/23802359.2020.1860698. PMID: 33537435; PMCID: PMC7832500
Misra A, Srivastava S, Verma S, Rawat AK. Nutritional evaluation, antioxidant studies and quantification of poly phenolics, in Roscoea purpurea tubers. BMC Res Notes. 2015 Jul 30;8:324. doi: 10.1186/s13104-015-1290-x. PMID: 26223698; PMCID: PMC4518606.
Lampariello LR, Cortelazzo A, Guerranti R, Sticozzi C, Valacchi G. The Magic Velvet Bean of Mucuna pruriens. J Tradit Complement Med. 2012 Oct;2(4):331-9. doi: 10.1016/s2225-4110(16)30119-5. PMID: 24716148; PMCID: PMC3942911.
Sageer Abass, Mohammad Irfan Dar, Sultan Zahiruddin, Md. Amjad Beg, Priyanka Nagar, Bisma Jan, Syed Akhtar Husain, Sayeed Ahmad, Phytochemical and antibacterial analysis of Pistacia integerrima: An integrated in vitro and in silico approach, Process Biochemistry,Volume 132, 2023, Pages 236-247, ISSN 1359-5113, https://doi.org/10.1016/j.procbio.2023.07.020.
Sahoo HB, Bhaiji A, Santani DD. Lactogenic activity of Teramnus labialis (Linn.) fruit with special reference to the estimation of serum prolactin and cortisol level in nursing rats. Indian J Pharmacol. 2016 Nov-Dec;48(6):715-719. doi: 10.4103/0253-7613.194856. PMID: 28066113; PMCID: PMC5155476.
Nitin T. Gore, Sumaiya S. Shaikh, Vikas A. Sule, Suraj D. Umdale, Pankaj S. Mundada, Nikhil B. Gaikwad, Mahendra L. Ahire, Understanding the nutritional profile of Vigna trilobata: A lesser-known, underexplored grain legume, Food and Humanity, Volume 3, 2024, 100343, ISSN 2949-8244, https://doi.org/10.1016/j.foohum.2024.100343.
Nayana Devidas Patil. Mucunapruriens: Phytopharmacological Review. Research J. Pharmacognosy and Phytochemistry 2012; 4(3): 158-163.
Mengmeng Liu, Jingwen Xue, Yuxin Cao, Zhuangzhuang Hao, Yuqing Wang, Jiayuan Li, Tingyue Jiang, Jinli Shi,The effects of Nardosinone on levodopa intervention in the treatment of Parkinson's disease, Biomedicine & Pharmacotherapy,Volume 174, 2024, 116448,ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2024.116448 .
Ram N, Peak SL, Perez AR, Jinwal UK. Implications of Withaferin A in neurological disorders. Neural Regen Res. 2021 Feb;16(2):304-305. doi: 10.4103/1673-5374.290894. PMID: 32859786; PMCID: PMC7896225.
https://www.sciencedirect.com/topics/medicine-and-dentistry/antiparkinson agent#:~:text=Antiparkinsonian,Mechanism%20Of%20Action,and%20symptoms%20of%20Parkinson%27s%20disease
Duarte-Jurado AP, Gopar-Cuevas Y, Saucedo-Cardenas O, Loera-Arias MJ, Montes-de-Oca-Luna R, Garcia-Garcia A, Rodriguez-Rocha H. Antioxidant Therapeutics in Parkinson's Disease: Current Challenges and Opportunities. Antioxidants (Basel). 2021 Mar 15;10(3):453. doi: 10.3390/antiox10030453. PMID: 33803945; PMCID: PMC7998929.
Coskun O, Kanter M, Korkmaz A, Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacol Res. 2005 Feb;51(2):117-23. doi: 10.1016/j.phrs.2004.06.002. PMID: 15629256.
Silvestro S, Sindona C, Bramanti P, Mazzon E. A State of the Art of Antioxidant Properties of Curcuminoids in Neurodegenerative Diseases. Int J Mol Sci. 2021 Mar 20;22(6):3168. doi: 10.3390/ijms22063168. PMID: 33804658; PMCID: PMC8003642.
Saxena G, Mittal A, Siddiqui AW, Acute Toxicity Studies and In-vitro Antioxidant Potential of Solanum indicum, Journal of Drug Delivery and Therapeutics. 2019; 9(3-s):736-739 http://dx.doi.org/10.22270/jddt.v9i3-s.2969
Huang S, Liu H, Lin Y, Liu M, Li Y, Mao H, Zhang Z, Zhang Y, Ye P, Ding L, Zhu Z, Yang X, Chen C, Zhu X, Huang X, Guo W, Xu P, Lu L. Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impairment in MPTP-Induced Parkinson's Disease Model. Front Pharmacol. 2021 Jan 27;11:618787. doi: 10.3389/fphar.2020.618787. PMID: 33584302; PMCID: PMC7872967.
Das N, Bhattacharya A, Kumar Mandal S, Debnath U, Dinda B, Mandal SC, Kumar Sinhamahapatra P, Kumar A, Dutta Choudhury M, Maiti S, Palit P. Ichnocarpus frutescens (L.) R. Br. root derived phyto-steroids defends inflammation and algesia by pulling down the pro-inflammatory and nociceptive pain mediators: An in-vitro and in-vivo appraisal. Steroids. 2018 Nov;139:18-27. doi: 10.1016/j.steroids.2018.09.005. Epub 2018 Sep 12. PMID: 30217788.
Zhuang Z,Ye G, Huang B. Kaempferol Alleviates the Interleukin-1β-Induced Inflammation in Rat Osteoarthritis Chondrocytes via Suppression of NF-κB. Med Sci Monit. 2017 Aug 14;23:3925-3931. doi: 10.12659/msm.902491. PMID: 28806392; PMCID: PMC5566200.
Sen A. Prophylactic and therapeutic roles of oleanolic acid and its derivatives in several diseases. World J Clin Cases. 2020 May 26;8(10):1767-1792. doi: 10.12998/wjcc.v8.i10.1767. PMID: 32518769; PMCID: PMC7262697.
Gagne JJ, Power MC. Anti-inflammatory drugs and risk of Parkinson disease: a meta-analysis. Neurology. 2010 Mar 23;74(12):995-1002. doi: 10.1212/WNL.0b013e3181d5a4a3. PMID: 20308684; PMCID: PMC2848103.
Xu J, Cao K, Liu X, Zhao L, Feng Z, Liu J. Punicalagin Regulates Signaling Pathways in Inflammation-Associated Chronic Diseases. Antioxidants (Basel). 2021 Dec 24;11(1):29. doi: 10.3390/antiox11010029. PMID: 35052533; PMCID: PMC8773334.
Shreyasi Majumdar, Smriti Gupta, Santosh Kumar Prajapati, Sairam Krishnamurthy, Neuro-nutraceutical potential of Asparagus racemosus: A review, Neurochemistry International, Volume 145, 2021,105013, ISSN 0197-0186, https://doi.org/10.1016/j.neuint.2021.105013.
Seidl SE, Potashkin JA. The promise of neuroprotective agents in Parkinson's disease. Front Neurol. 2011 Nov 21;2:68. doi: 10.3389/fneur.2011.00068. Erratum in: Front Neurol. 2013;7:69. PMID: 22125548; PMCID: PMC3221408. https://www.sciencedirect.com/topics/medicine-and-dentistry/neuroprotection
Paramanick D, Singh VD, Singh VK. Neuroprotective effect of phytoconstituents via nanotechnology for treatment of Alzheimer diseases. J Control Release. 2022 Nov;351:638-655. doi: 10.1016/j.jconrel.2022.09.058. Epub 2022 Oct 6. PMID: 36191675.
Mishra A, Das S, Kumari S. Potential role of herbal plants and beta sitosterol as a bioactive constituent in circumventing Parkinson’s Disease. Plant Sci. Today [Internet]. 2024 Jan. 14 [cited 2024 Dec. 18];11(1):454-65. Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/2420
Olson KE, Gendelman HE. Immunomodulation as a neuroprotective and therapeutic strategy for Parkinson's disease. Curr Opin Pharmacol. 2016 Feb;26:87-95. doi: 10.1016/j.coph.2015.10.006. Epub 2015 Nov 11. PMID: 26571205;
Islam MS, Hossain R, Ahmed T, Rahaman MM, Al-Khafaji K, Khan RA, Sarkar C, Bappi MH, de Andrade EM, Araújo IM, Coutinho HDM, Kowalska G, Kowalski R, Hanif MA, Islam MT. Anxiolytic-like Effect of Quercetin Possibly through GABA Receptor Interaction Pathway: In Vivo and In Silico Studies. Molecules. 2022 Oct 22;27(21):7149. doi: 10.3390/molecules27217149. PMID: 36363979; PMCID: PMC9656213.
Vissiennon C, Nieber K, Kelber O, Butterweck V. Route of administration determines the anxiolytic activity of the flavonols kaempferol, quercetin and myricetin--are they prodrugs? J Nutr Biochem. 2012 Jul;23(7):733-40. doi: 10.1016/j.jnutbio.2011.03.017. Epub 2011 Aug 12. PMID: 21840194.
Chen JJ, Marsh L. Anxiety in Parkinson's disease: identification and management. Ther Adv Neurol Disord. 2014 Jan;7(1):52-9. doi: 10.1177/1756285613495723. PMID: 24409202; PMCID: PMC3886380
Lopresti AL. Potential Role of Curcumin for the Treatment of Major Depressive Disorder. CNS Drugs. 2022 Feb;36(2):123-141. doi: 10.1007/s40263-022-00901-9. Epub 2022 Feb 7. PMID: 35129813; PMCID: PMC8863697.
Speers AB, Cabey KA, Soumyanath A, Wright KM. Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021;19(9):1468-1495. doi: 10.2174/1570159X19666210712151556. PMID: 34254920; PMCID: PMC8762185.
Chen S, Tang Y, Gao Y, Nie K, Wang H, Su H, Wang Z, Lu F, Huang W, Dong H. Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update. Front Pharmacol. 2022 Apr 8;13:865376. doi: 10.3389/fphar.2022.865376. PMID: 35462940; PMCID: PMC9024056.
Peña, M. Mata, L. López-Manzanares, M. Kurtis, M. Eimil, J.C. MartÃnez-Castrillo, I. Navas, I.J. Posada, C. Prieto, C. RuÃz-Huete, L. Vela, B. Venegas,Antidepressants in Parkinson's disease. Recommendations by the movement disorder study group of the Neurological Association of Madrid, NeurologÃa (English Edition),Volume 33, Issue 6, 2018, Pages 395-402, ISSN 2173-5808, https://doi.org/10.1016/j.nrleng.2016.02.017
Panayotis N, Freund PA, Marvaldi L, Shalit T, Brandis A, Mehlman T, Tsoory MM, Fainzilber M. β-sitosterol reduces anxiety and synergizes with established anxiolytic drugs in mice. Cell Rep Med. 2021 May 18;2(5):100281. doi: 10.1016/j.xcrm.2021.100281. PMID: 34095883; PMCID: PMC8149471.
Joshi, B.R., Hakim, M.M. & Patel, I.C. The biological active compounds and biological activities of Desmodium species from Indian region: a review. Beni-Suef Univ J Basic Appl Sci 12, 1 (2023). https://doi.org/10.1186/s43088-022-00339-4
Kosksi, T., Selmi, A., Mani, S., Ben Rhouma, M., Boughammoura, S., Knani, L., Kessabi, K. and Messaoudi, I. 2021. Antinociceptive effect of melatonin in the animal model of Parkinson’s disease. Melatonin Research. 4, 3 (Sept. 2021), 440-452. DOI:https://doi.org/https://doi.org/10.32794/mr112500104.
Goozee KG, Shah TM, Sohrabi HR, Rainey-Smith SR, Brown B, Verdile G, Martins RN. Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease. Br J Nutr. 2016 Feb 14;115(3):449-65. doi: 10.1017/S0007114515004687. Epub 2015 Dec 14. PMID: 26652155.
Wen J, Liu L, Li J, He Y. A review of nardosinone for pharmacological activities. Eur J Pharmacol. 2021 Oct 5;908:174343. doi: 10.1016/j.ejphar.2021.174343. Epub 2021 Jul 12. PMID: 34265296.
Das R, Rauf A, Akhter S, Islam MN, Emran TB, Mitra S, Khan IN, Mubarak MS. Role of Withaferin A and Its Derivatives in the Management of Alzheimer's Disease: Recent Trends and Future Perspectives. Molecules. 2021 Jun 17;26(12):3696. doi: 10.3390/molecules26123696. PMID: 34204308; PMCID: PMC8234716.
Chiang MC, Tsai TY, Wang CJ. The Potential Benefits of Quercetin for Brain Health: A Review of Anti-Inflammatory and Neuroprotective Mechanisms. Int J Mol Sci. 2023 Mar 28;24(7):6328. doi: 10.3390/ijms24076328. PMID: 37047299; PMCID: PMC10094159.
Suliman NA, Mat Taib CN, Mohd Moklas MA, Adenan MI, Hidayat Baharuldin MT, Basir R. Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic. Evid Based Complement Alternat Med. 2016;2016:4391375. doi: 10.1155/2016/4391375. Epub 2016 Aug 30. PMID: 27656235; PMCID: PMC5021479.
Nimgulkar, C. C., & Patwardhan, B. (2014). Ghee’s role in neuroprotective and cognitive-enhancing processes in Ayurvedic medicine.
