Effect Of Various Electrical Stimulation On Peripheral Nerve Injury: A Systemic Review And Meta Analysis
Abstract
Peripheral nerve injuries (PNIs) significantly affect quality of life, often resulting in motor, sensory, and autonomic deficits. Various electrical stimulation (ES) modalities have been explored as potential interventions to enhance nerve regeneration and functional recovery. This systematic review and meta-analysis aims to evaluate the effects of different ES modalities on outcomes related to peripheral nerve injury. Databases including PubMed, Scopus, and Cochrane Library were searched for relevant randomized controlled trials (RCTs) and observational studies up to December 2024. Key outcomes assessed included nerve conduction velocity, muscle strength, sensory recovery, and functional improvement. Statistical analysis was performed to compute pooled effect sizes using a random-effects model. Our findings suggest that specific ES modalities, such as functional electrical stimulation (FES) and transcutaneous electrical nerve stimulation (TENS), are associated with significant improvements in nerve regeneration and functional recovery compared to control groups. However, heterogeneity among studies highlights the need for standardized protocols and further high-quality RCTs.
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