The Effect Of Transcranial Direct Current Stimulation In Traumatic Brain Injury-A Meta Analysis
Abstract
Transcranial direct current stimulation (tDCS) has emerged as a promising non-invasive technique to enhance neuroplasticity and recovery in patients with traumatic brain injury (TBI). This meta-analysis evaluates the efficacy of tDCS in cognitive and motor recovery across multiple studies. Data from various randomized controlled trials (RCTs) were synthesized to assess its impact on memory, executive function, strength, and coordination. Significant improvements were observed in cognitive and motor domains, with long-term benefits in quality of life. However, heterogeneity in study designs and tDCS protocols underscores the need for standardized guidelines. This study highlights the potential of tDCS as an adjunct therapy in TBI rehabilitation.
References
2. Kang, E. K., Kim, Y. K., Sohn, H. M., & Cohen, L. G. (2015). Improved motor function in stroke patients with the administration of tDCS combined with physical therapy. Journal of Neurophysiology, 113(1), 1-11.
3. Nitsche, M. A., & Paulus, W. (2000). Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. The Journal of Physiology, 527(3), 633-639.
4. Fregni, F., Boggio, P. S., Nitsche, M., Bermpohl, F., Antal, A., Feredoes, E., & Pascual-Leone, A. (2005). Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory. Experimental Brain Research, 166(1), 23-30.
5. Lindenberg, R., Nachtigall, L., Meinzer, M., Sieg, M. M., & Flöel, A. (2013). Differential effects of dual and unihemispheric motor cortex stimulation in older adults. Journal of Neuroscience, 33(21), 9176-9183.
6. Bikson, M., Brunoni, A. R., Charvet, L. E., Clark, V. P., Cohen, L. G., Dmochowski, J., & Woods, A. J. (2018). Rigor and reproducibility in research with transcranial electrical stimulation: An NIMH-sponsored workshop. Brain Stimulation, 11(3), 465-480
7. Bolognini, N., Pascual-Leone, A., & Fregni, F. (2009). Using non-invasive brain stimulation to augment motor training-induced plasticity. Journal of NeuroEngineering and Rehabilitation, 6(1),
8. Villamar, M. F., Wivatvongvana, P., Patumanond, J., Bikson, M., & Fregni, F. (2013). Safety and feasibility of transcranial direct current stimulation in acute stroke rehabilitation (TCT Stroke Trial): A randomized, sham-controlled, double-blind trial. Stroke, 44(11), 3165-3171
9. Levine, B., Cabeza, R., McIntosh, A. R., Black, S. E., Grady, C. L., Stuss, D. T., & Craik, F. I. M. (2014). Functional reorganization of cognitive networks during memory tasks in TBI patients with chronic deficits. Cerebral Cortex, 14(10), 1210-1220.
10. Filmer, H. L., Dux, P. E., & Mattingley, J. B. (2014). Applications of transcranial direct current stimulation for understanding brain function. Trends in Neurosciences, 37(12), 742-753.
11. Pope, P. A., Miall, R. C., & Wing, A. M. (2017). Motor learning, consolidation, and transfer after repetitive practice and tDCS: Evidence for function-specific neural adaptations. Journal of Neurophysiology, 119(2), 725-733.
12. Brunoni, A. R., Nitsche, M. A., Bolognini, N., Bikson, M., Wagner, T., Merabet, L., & Pascual-Leone, A. (2012). Clinical research with transcranial direct current stimulation (tDCS): Challenges and future directions. Brain Stimulation, 5(3), 175-195.
13. Kuo, M. F., & Nitsche, M. A. (2012). Effects of transcranial electrical stimulation on cognition. Clinical EEG and Neuroscience, 43(3), 192-199.
14. Schlaug, G., Marchina, S., & Wan, C. Y. (2011). The use of non-invasive brain stimulation techniques to facilitate recovery from post-stroke aphasia. Neuropsychology Review, 21(3), 288-301.
15. Villamar, M. F., Santos Portilla, A., Fregni, F., & Zafonte, R. (2012). Noninvasive brain stimulation to modulate neuroplasticity in traumatic brain injury. Neurorehabilitation and Neural Repair, 26(5), 623-631.