Next-Generation Pulmonary Therapies: Personalized Tablets as a Game Changer in Asthma Treatment

  • Krutika Mandloi
  • Kratika Khadsondni
  • Aman Kumar
  • Tushar Sonare
  • Akash Yadav
  • Dr. Dinesh Kumar Jain
Keywords: Pulmonary drug delivery system, Asthma, Personalized medicines, Dosage forms, Orodispersible tablets, Evaluation parameters.

Abstract

The third greatest cause of death worldwide is respiratory illness, which includes asthma and chronic obstructive pulmonary disease (COPD). Both adults and children can suffer from asthma, a chronic inflammatory illness that is characterized by reversible airway constriction and hyperresponsiveness. Prevalence rates are greater in metropolitan regions such as Delhi, Mumbai, and Kolkata (8-10%) than in rural areas (3-5%). Asthma is made worse by poor air quality, particularly during pollution surges; in Delhi, emergency visits increase by 50% during these months. Even though asthma is common, many patients-particularly in rural areas-do not obtain the right diagnosis or treatment, and only 40-50% of them utilize their inhalers as prescribed. According to a poll conducted in 2021, 60% of Indian asthma sufferers know very little about how to treat their illness. Potential remedies are provided by innovative dosage forms including orodispersible pills and personalized medications. Orodispersible tablets are particularly helpful for patients who have trouble swallowing or who need fast medication release since they dissolve swiftly in the mouth without the need for water. These dose forms are a viable alternative for the treatment of asthma and other chronic illnesses because they increase patient compliance and improve therapeutic results.

Author Biographies

Krutika Mandloi

IPS Academy College of Pharmacy, Knowledge Village, Rajan Nagar A. B. Road, Indore

Kratika Khadsondni

IPS Academy College of Pharmacy, Knowledge Village, Rajan Nagar A. B. Road, Indore

Aman Kumar

IPS Academy College of Pharmacy, Knowledge Village, Rajan Nagar A. B. Road, Indore

Tushar Sonare

IPS Academy College of Pharmacy, Knowledge Village, Rajan Nagar A. B. Road, Indore

Akash Yadav

IPS Academy College of Pharmacy, Knowledge Village, Rajan Nagar A. B. Road, Indore

Dr. Dinesh Kumar Jain

IPS Academy College of Pharmacy, Knowledge Village, Rajan Nagar A. B. Road, Indore

References

1. Modaresi MA, Shirani E. Effect of mucociliary clearance on the particulate airflow inside the nasal sinus and its role in increasing the residence time and absorption of drug inside the upper respiratory pathway. Journal of drug delivery science and technology. 2023;89-90.
2. Mishra B, Singh J. Novel drug delivery system and significance in respiratory diseases. Targeting chronic inflammatory lung diseases using Advanced Drug Delivery System. Elsevier. 2020;57-95.
3. Rangaraj N, Pailla SR, Sampathi S. Insight into pulmonary drug delivery: Mechanism of drug deposition to device characterization and regulatory requirements. Pulmonary Pharmacology and Therapeutics. Elsevier. 2019;54:1-21.
4. Debata B, Mohapatra SK, Priyadarshini R. A systematic literature review on pulmonary disease detection using machine learning. Proceedings of the International Conference on Cognitive and Intelligent Computing. 2023;515-522.
5. Clifton IJ, Ellames DAB. Respiratory medicine. In: Penman ID, Ralston SH, Strachan MWJ, Hobson RP, eds. Davidson's Principles and Practice of Medicine. Philadelphia, PA: Elsevier; 2022;26-43.
6. Rathod HK, Katekar VA, Dhole YR, Nalinde PS. Pulmonary drug delivery system: A review. GSC Biological and Pharmaceutical Sciences. 2023;25(3):149-58.
7. Chow MYT, Chang RYK, Chan HK. Inhalation delivery technology for genome-editing of respiratory diseases. Advanced Drug Delivery Review. Elsevier. 2021;168:217-228.
8. Dash A, Singh S, editors. Pharmaceutics: basic principles and application to pharmacy practice. Elsevier; 2023;68-79.
9. Kumar N. Nanoparticle-based macromolecule drug delivery to lungs. targeting chronic inflammatory lung diseases using advanced drug delivery systems. academic press. 2020;227-259.
10. Anne HB. Metered dose inhalers (MDIs): inhaled medicine Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches. academic press. 2021;65-
97.
11. Chandel A. A recent advances in aerosolised drug delivery. biomedicine and pharmacotherapy. Elsevier. 2019;112-135.
12. Chaurasiya B, Zhao YY. Dry powder for pulmonary delivery: a comprehensive review. Pharmaceutics. 2021;13(1):31-38.
13. Gaikwad SS, Patare SR, More MA, Waykhinde NA, Laddha UD, Salunkhe KS, et.al. Dry powder inhaler with the technical and practical obstacles and forthcoming platform strategies. Journal of Controlled Release. 2023;355:292-311.
14. Todor AP. Medical devices in allergy practice. world allergy organizational journal. Elsevier. 2020;13(10):88-97.
15. Clifton IJ, Ellames DAB. Respiratory medicine. In: Penman ID, Ralston SH, Strachan MWJ, Hobson RP, eds. Davidson's Principles and Practice of Medicine. Philadelphia, PA: Elsevier; 2022;24:54-67.
16. Chen X, Zhou CW, Fu YY, Li YZ, Chen L, Zhang QW, Chen YF. Global, regional, and national burden of chronic respiratory diseases and associated risk factors, 1990–2019: Results from the Global Burden of Disease Study 2019. Frontiers in medicine. 2023;10:106-127.
17. Salter B, Lacy P, Mukherjee M. Biologics in asthma: a molecular perspective to precision medicine. Frontiers in pharmacology. 2022;12:793-804.
18. Brunaugh AD, Sharma S, Smyth H. Inhaled fixed-dose combination powders for the treatment of respiratory infections. Expert opinion on drug delivery. 2021;18(8):11-25.
19. Fei Q, Bently I, Ghadiali SN, Englert JA. Pulmonary drug delivery for acute respiratory distress syndrome. Pulmonary Pharmacology and Therapeutics. 2023;79:102-196.
20. Nagasaki Tadao, Wenzel Sally E. Asthma exacerbations and airway redox imbalance under type 2 inflammatory conditions. Respiratory Investigation, 2024:62(6);923-928.
21. Simpson Andrew J, Drake Sarah, Healy Laura, Wang Ran, Bennett Miriam, Wardman Hannah, Durrington Hannah, Fowler Stephen J, Murray Clare S, Simpson Angela. Asthma diagnosis: a comparison of established diagnostic guidelines in adults with respiratory symptoms. eClinicalMedicine. 2024:76;102-813.
22. Kumar Vishal, Bhardwaj Attish, Singh Navdeep, Goyal Kamya, Jindal Shammy. A Review on Tablet Dosage Form: Recent Advancements with Special Emphasis on Rapid. Disintegrating Tablet. Asian Journal of Research in Pharmaceutical Sciences.2021:11(3);237-246.
23. Kumar Naveen, Pahuja Sonia. Dispersible tablets: an overview. Journal of Medical Pharmaceutical and Allied Sciences. 2019:8(3);2183-2199.
24. Tejas K, Ganesh D. A Review on Orodispersible Tablets: A Novel Approach. Research Journal of Pharmacy and Technology. 2019;12(8):3993-4001.
25. Jassem NA. Orodispersible tablets: A review on recent trends in drug delivery. International Journal of Drug Delivery. 2022;12:43-56.
Published
2024-12-18
How to Cite
Krutika Mandloi, Kratika Khadsondni, Aman Kumar, Tushar Sonare, Akash Yadav, & Dr. Dinesh Kumar Jain. (2024). Next-Generation Pulmonary Therapies: Personalized Tablets as a Game Changer in Asthma Treatment. Revista Electronica De Veterinaria, 25(1), 3038-3050. https://doi.org/10.69980/redvet.v25i1.1463
Section
Articles