Exploring the new horizons in hypertension involving the use of specialized tablets

  • Akash Yadav
  • Kratika Khadsondni
  • Krutika Mandloi
  • Tushar Sonare
  • Aman Kumar
  • Dinesh Kumar Jain
Keywords: Specialized tablet, Dosage Form, Layered tablet, Method of Preparation of tablets, Evaluation of tablets.

Abstract

Tablets are a highly stable and convenient dosage form, offering benefits such as ease of manufacture, packaging, and transport. They protect active pharmaceutical ingredients (APIs) from environmental factors like moisture, light, and oxygen, and can mask unpleasant flavors or odors. Tablets are particularly suitable for chronic diseases like hypertension and cardiovascular disorders, where easy self-medication is a key advantage. Hypertension, often called the "silent killer," affects over 1 billion people worldwide and is a leading cause of death. Specialized tablets, such as bilayer tablets, address limitations of traditional forms by improving drug bioavailability, targeting specific organs, and enhancing therapeutic efficacy with reduced dosing frequency.

The design and manufacture of tablets involve several critical factors, including appearance, thickness, hardness, weight variation, and content uniformity. Testing methods like friability, swelling index, mucoadhesive strength, disintegration, and in vitro dissolution are essential for ensuring the quality and performance of the tablets. Advanced manufacturing techniques, including wet, dry, and direct granulation, are employed to optimize the tablet's properties, ensuring effective drug delivery. These methods help overcome issues like poor absorption, solubility, and first-pass metabolism, ultimately improving patient compliance and safety.

Author Biographies

Akash Yadav

IPS Academy College of Pharmacy, Knowledge Village, Rajendra Nagar, A.B. Road, Indore-452012

Kratika Khadsondni

IPS Academy College of Pharmacy, Knowledge Village, Rajendra Nagar, A.B. Road, Indore-452012

Krutika Mandloi

IPS Academy College of Pharmacy, Knowledge Village, Rajendra Nagar, A.B. Road, Indore-452012

Tushar Sonare

IPS Academy College of Pharmacy, Knowledge Village, Rajendra Nagar, A.B. Road, Indore-452012

Aman Kumar

IPS Academy College of Pharmacy, Knowledge Village, Rajendra Nagar, A.B. Road, Indore-452012

Dinesh Kumar Jain

IPS Academy College of Pharmacy, Knowledge Village, Rajendra Nagar, A.B. Road, Indore-452012

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Published
2024-12-09
How to Cite
Akash Yadav, Kratika Khadsondni, Krutika Mandloi, Tushar Sonare, Aman Kumar, & Dinesh Kumar Jain. (2024). Exploring the new horizons in hypertension involving the use of specialized tablets. Revista Electronica De Veterinaria, 25(1), 2976 -2989. https://doi.org/10.69980/redvet.v25i1.1446
Section
Articles