Exploring The Antidiabetic Effects Of Murraya Koenigii And Abelmoschus Esculentus Extracts In Diabetic Rat Models
Keywords:
Murraya koenigii, diabetes, dementia, neurodegeneration, oxidative stress, anti-oxidant, nootropic
Abstract
The potential antidiabetic exercises of watery extracts of Murraya koenigii and Abelmoschus esculentus are investigated in this study using alloxan-induced diabetic Wistar rats. Subsequent to collecting, verifying, and cold macerating Murraya koenigii leaves, a fluid concentrate (AEMK) was delivered; the recommended therapeutic portion was 300 mg/kg body weight. The standard treatment was giving the patient 150 milligrams of metformin for each kilogram of body weight. By administering rats alloxan to induce diabetes, intense poisonousness tests determined the protected portion of AEMK. Then, the rats were partitioned into four gatherings: the control bunch, the diabetic gathering, the gathering that got AEMK treatment, and the gathering that got Metformin treatment. The diabetic rats' FBS levels were essentially lower than the diabetic control bunch after treatment with AEMK and Metformin, according to week after week blood glucose monitoring. The consequences of this study recommend that AEMK may be helpful in the treatment of diabetes mellitus due to its antidiabetic properties, which are practically identical to those of Metformin. The way that the examination effectively decreased fasting blood sugar levels demonstrated this.
References
1. Ansari, P., Akther, S., Hannan, J. M. A., Seidel, V., Nujat, N. J., & Abdel-Wahab, Y. H. (2022). Pharmacologically active phytomolecules isolated from traditional antidiabetic plants and their therapeutic role for the management of diabetes mellitus. Molecules, 27(13), 4278.
2. Azeem, U., & Hakeem, K. R. (Eds.). (2023). Therapeutic mushrooms for diabetes mellitus: Current evidences and future scope. CRC Press.
3. Bamon, F. (2023). Ethnomedicinal Plants Used by the Pnar Tribes of Meghalaya for the Treatment of Diabetes Mellitus. Journal of Tropical Life Science, 13(3).
4. Bora, K. S., & Shri, R. (2023). Natural Products for the Management of Diabetes: Achievements and Future Trends. Therapeutic Mushrooms for Diabetes Mellitus, 13-33.
5. Chattopadhyay, K., Wang, H., Kaur, J., Nalbant, G., Almaqhawi, A., Kundakci, B., ... & Leonardi-Bee, J. (2022). Effectiveness and safety of Ayurvedic medicines in type 2 diabetes mellitus management: a systematic review and meta-analysis. Frontiers in pharmacology, 13, 821810.
6. Firdhouse, M. J., & Lalitha, P. (2022). Biogenic green synthesis of gold nanoparticles and their applications–a review of promising properties. Inorganic Chemistry Communications, 143, 109800.
7. Javed, R., Ghonaim, R., Shathili, A., Khalifa, S. A., & El-Seedi, H. R. (2021). Phytonanotechnology: A greener approach for biomedical applications. In Biogenic nanoparticles for cancer theranostics (pp. 43-86). Elsevier.
8. Jimmy, J. L. (2021). Coleus aromaticus Benth.: an update on its bioactive constituents and medicinal properties. All Life, 14(1), 756-773.
9. Kambale, E. K., Quetin-Leclercq, J., Memvanga, P. B., & Beloqui, A. (2022). An overview of herbal-based antidiabetic drug delivery systems: Focus on lipid-and inorganic-based nanoformulations. Pharmaceutics, 14(10), 2135.
10. Kumari, S., Saini, R., Bhatnagar, A., & Mishra, A. (2023). Exploring plant-based alpha-glucosidase inhibitors: promising contenders for combatting type-2 diabetes. Archives of Physiology and Biochemistry, 1-16.
11. Majithia, M., & Barretto, D. A. (2023). Biocompatible green-synthesized nanomaterials for therapeutic applications. In Advances in Nano and Biochemistry (pp. 285-367). Academic Press.
12. Murali, M., Kalegowda, N., Gowtham, H. G., Ansari, M. A., Alomary, M. N., Alghamdi, S., ... & Amruthesh, K. N. (2021). Plant-mediated zinc oxide nanoparticles: advances in the new millennium towards understanding their therapeutic role in biomedical applications. Pharmaceutics, 13(10), 1662.
13. Nanda, J., Verma, N., & Mani, M. (2023). A mechanistic review on phytomedicine and natural products in the treatment of diabetes. Current Diabetes Reviews, 19(7), 44-54.
14. Paes, A. S., Koga, R. D. C. R., Sales, P. F., Santos Almeida, H. K., Teixeira, T. A. C. C., & Carvalho, J. C. T. (2023). Phytocompounds from Amazonian Plant Species against Acute Kidney Injury: Potential Nephroprotective Effects. Molecules, 28(17), 6411.
15. Pareek, A., Pant, M., Gupta, M. M., Kashania, P., Ratan, Y., Jain, V., ... & Chuturgoon, A. A. (2023). Moringa oleifera: An updated comprehensive review of its pharmacological activities, ethnomedicinal, phytopharmaceutical formulation, clinical, phytochemical, and toxicological aspects. International journal of molecular sciences, 24(3), 2098.
16. Pattanayak, S. (2022). Prevention and control of diabetes by intake of succulent biomedicines and following of designed lifestyle: A ready plan for execution. International Journal of Scientific Research Updates, 3(2), 081-103.
17. Puri, A., Mohite, P., Maitra, S., Subramaniyan, V., Kumarasamy, V., Uti, D. E., ... & Atangwho, I. J. (2024). From nature to nanotechnology: The interplay of traditional medicine, green chemistry, and biogenic metallic phytonanoparticles in modern healthcare innovation and sustainability. Biomedicine & Pharmacotherapy, 170, 116083.
18. Rajendram, R., Preedy, V., & Patel, V. (Eds.). (2023). Ancient and Traditional Foods, Plants, Herbs and Spices Used in Diabetes. CRC Press.
19. Sivakami, M., Renuka Devi, K., & Renuka, R. (2022). Phytomediated synthesis of magnetic nanoparticles by Murraya koenigii leaves extract and its biomedical applications. Applied Physics A, 128(4), 272.
20. Zulcafli, A. S., Lim, C., Ling, A. P., Chye, S., & Koh, R. (2020). Focus: plant-based medicine and pharmacology: Antidiabetic potential of Syzygium sp.: An overview. The Yale journal of biology and medicine, 93(2), 307.
2. Azeem, U., & Hakeem, K. R. (Eds.). (2023). Therapeutic mushrooms for diabetes mellitus: Current evidences and future scope. CRC Press.
3. Bamon, F. (2023). Ethnomedicinal Plants Used by the Pnar Tribes of Meghalaya for the Treatment of Diabetes Mellitus. Journal of Tropical Life Science, 13(3).
4. Bora, K. S., & Shri, R. (2023). Natural Products for the Management of Diabetes: Achievements and Future Trends. Therapeutic Mushrooms for Diabetes Mellitus, 13-33.
5. Chattopadhyay, K., Wang, H., Kaur, J., Nalbant, G., Almaqhawi, A., Kundakci, B., ... & Leonardi-Bee, J. (2022). Effectiveness and safety of Ayurvedic medicines in type 2 diabetes mellitus management: a systematic review and meta-analysis. Frontiers in pharmacology, 13, 821810.
6. Firdhouse, M. J., & Lalitha, P. (2022). Biogenic green synthesis of gold nanoparticles and their applications–a review of promising properties. Inorganic Chemistry Communications, 143, 109800.
7. Javed, R., Ghonaim, R., Shathili, A., Khalifa, S. A., & El-Seedi, H. R. (2021). Phytonanotechnology: A greener approach for biomedical applications. In Biogenic nanoparticles for cancer theranostics (pp. 43-86). Elsevier.
8. Jimmy, J. L. (2021). Coleus aromaticus Benth.: an update on its bioactive constituents and medicinal properties. All Life, 14(1), 756-773.
9. Kambale, E. K., Quetin-Leclercq, J., Memvanga, P. B., & Beloqui, A. (2022). An overview of herbal-based antidiabetic drug delivery systems: Focus on lipid-and inorganic-based nanoformulations. Pharmaceutics, 14(10), 2135.
10. Kumari, S., Saini, R., Bhatnagar, A., & Mishra, A. (2023). Exploring plant-based alpha-glucosidase inhibitors: promising contenders for combatting type-2 diabetes. Archives of Physiology and Biochemistry, 1-16.
11. Majithia, M., & Barretto, D. A. (2023). Biocompatible green-synthesized nanomaterials for therapeutic applications. In Advances in Nano and Biochemistry (pp. 285-367). Academic Press.
12. Murali, M., Kalegowda, N., Gowtham, H. G., Ansari, M. A., Alomary, M. N., Alghamdi, S., ... & Amruthesh, K. N. (2021). Plant-mediated zinc oxide nanoparticles: advances in the new millennium towards understanding their therapeutic role in biomedical applications. Pharmaceutics, 13(10), 1662.
13. Nanda, J., Verma, N., & Mani, M. (2023). A mechanistic review on phytomedicine and natural products in the treatment of diabetes. Current Diabetes Reviews, 19(7), 44-54.
14. Paes, A. S., Koga, R. D. C. R., Sales, P. F., Santos Almeida, H. K., Teixeira, T. A. C. C., & Carvalho, J. C. T. (2023). Phytocompounds from Amazonian Plant Species against Acute Kidney Injury: Potential Nephroprotective Effects. Molecules, 28(17), 6411.
15. Pareek, A., Pant, M., Gupta, M. M., Kashania, P., Ratan, Y., Jain, V., ... & Chuturgoon, A. A. (2023). Moringa oleifera: An updated comprehensive review of its pharmacological activities, ethnomedicinal, phytopharmaceutical formulation, clinical, phytochemical, and toxicological aspects. International journal of molecular sciences, 24(3), 2098.
16. Pattanayak, S. (2022). Prevention and control of diabetes by intake of succulent biomedicines and following of designed lifestyle: A ready plan for execution. International Journal of Scientific Research Updates, 3(2), 081-103.
17. Puri, A., Mohite, P., Maitra, S., Subramaniyan, V., Kumarasamy, V., Uti, D. E., ... & Atangwho, I. J. (2024). From nature to nanotechnology: The interplay of traditional medicine, green chemistry, and biogenic metallic phytonanoparticles in modern healthcare innovation and sustainability. Biomedicine & Pharmacotherapy, 170, 116083.
18. Rajendram, R., Preedy, V., & Patel, V. (Eds.). (2023). Ancient and Traditional Foods, Plants, Herbs and Spices Used in Diabetes. CRC Press.
19. Sivakami, M., Renuka Devi, K., & Renuka, R. (2022). Phytomediated synthesis of magnetic nanoparticles by Murraya koenigii leaves extract and its biomedical applications. Applied Physics A, 128(4), 272.
20. Zulcafli, A. S., Lim, C., Ling, A. P., Chye, S., & Koh, R. (2020). Focus: plant-based medicine and pharmacology: Antidiabetic potential of Syzygium sp.: An overview. The Yale journal of biology and medicine, 93(2), 307.
Published
2024-10-08
How to Cite
Rajiv Yadav, Dr Suraj Bansal, Anamika kulshrestha, Dr Kavita Shukla, Namrata Singh, Jashanjit Singh, Dr. Ruchi Gupta, & Dr. Ritesh Kumar. (2024). Exploring The Antidiabetic Effects Of Murraya Koenigii And Abelmoschus Esculentus Extracts In Diabetic Rat Models. Revista Electronica De Veterinaria, 25(1), 2289 - 2297. https://doi.org/10.69980/redvet.v25i1.1154
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