Preclinical Evaluation Of Antidiabetic Properties Of Murraya Koenigii And Abelmoschus Esculentus In Diabetic Rats

  • Dr. Ankita Alice Singh
  • Ramenani Hari Babu
  • Dr. Vema Kiran
  • Yadav Suman Omprakash
  • Ritu Sharma
  • Dr. Vishal Garg
  • Dr. Krishna Chandra Panda
  • Dr. Sandeep Kumar Yadav
Keywords: Murraya koenigii, antidiabetic, antihyperlipidemic, streptozotocin, blood glucose, glycosylated hemoglobin, lipid profile, histopathology, diabetes management.

Abstract

The present study deals with the antidiabetic and antihyperlipidemic activities of Murraya koenigii, commonly known as curry leaves, extract on STZ-induced diabetic rats. The given dose of the extract to the rats in this study was 500 mg/kg body weight for 37 days and then estimated its effects on blood glucose and HbA1c levels and lipid profile. Results: The results indicated that Murraya koenigii has significant hypoglycemic activity since the blood glucose and HbA1c levels of the treated group were significantly reduced compared with the diabetic control group. The extract has also been found to possess antihyperlipidemic activity as there is a significant reduction in triglyceride levels and an increase in the level of HDL cholesterol, respectively. In addition, biochemical markers and histopathological examinations revealed no effect on the pancreas, liver, or kidneys due to this extract. These findings could suggest the possibility of using Murraya koenigii as a natural safe and effective treatment of diabetes mellitus, alongside its complications. Further studies should be recommended to validate these results in clinical trials.

Author Biographies

Dr. Ankita Alice Singh

Lecturer, Kalaniketan Polytechnic College, Jabalpur

Ramenani Hari Babu

Professor, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer  University, Moradabad, Uttar Pradesh, India. 244101

Dr. Vema Kiran

Professor, MB School of Pharmaceutical Sciences, Mohanbabu University, Tirupati, Andhra pradesh-517102

Yadav Suman Omprakash

Assistant professor (Pharmacology) Career Point School of Pharmacy, career Point University, Kota, Rajasthan

Ritu Sharma

 Assistant professor (Pharmacology) Career Point School of Pharmacy, career Point University, Kota, Rajasthan

Dr. Vishal Garg

Professor & Dean, Faculty of Pharmacy Maharaj Vinayak Global University, Jaipur, Rajasthan

Dr. Krishna Chandra Panda

Associate Professor, Roland Institute of Pharmaceutical Sciences, Khodasingi , Berhampur, Odisha

Dr. Sandeep Kumar Yadav

Professor, Department of Pharmacology, SGT College of Pharmacy, Shree Guru Gobind Singh Tricentenary (SGT) University, Gurugram, Haryana.pin code 122505

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Published
2024-10-08
How to Cite
Dr. Ankita Alice Singh, Ramenani Hari Babu, Dr. Vema Kiran, Yadav Suman Omprakash, Ritu Sharma, Dr. Vishal Garg, Dr. Krishna Chandra Panda, & Dr. Sandeep Kumar Yadav. (2024). Preclinical Evaluation Of Antidiabetic Properties Of Murraya Koenigii And Abelmoschus Esculentus In Diabetic Rats. Revista Electronica De Veterinaria, 25(1), 2278-2285. https://doi.org/10.69980/redvet.v25i1.1152
Section
Articles