Hydrotropic Solubilization: A Novel Approach For Enhancing Dissolution Of Antiemetic Drugs In Mouth Dissolving Tablets
Abstract
The purpose of this study is to investigate the hydrotropic solubilization approach as a means of improving the dissolution of the antiemetic medication aprepitant, which is known to be weakly water-soluble, in mouth-dissolving tablets (MDTs). In order to boost the drug's solubility, hydrotropic agents such as sodium benzoate and sodium acetate were utilized. Among these agents, sodium acetate at a ratio of 1:3 demonstrated the greatest solubility augmentation (12.053). The use of superdisintegrants such as sodium starch glycolate, crospovidone, and croscarmellose sodium allowed for the formulation of aprepitant solid dispersions into tablets that dissolve quickly. It was determined that the pre-compression characteristics, which included bulk density and flow properties, were within acceptable limits, which ensured that the tablet formation was satisfactory. Tablets were found to have suitable levels of hardness, friability, weight uniformity, and drug content after being subjected to compression testing. Formulation F7 had the highest level of performance among the tablets. In addition, F7 had the quickest disintegration time, which was only 38 seconds, and it reached practically total drug release within 15 minutes, according to first-order kinetics. Hydrotropic solubilization has shown to be a successful approach for enhancing the solubility and bioavailability of medications that are weakly water-soluble in MDTs, as demonstrated by this study.
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