Comparative Morphological Study Of Hypertensive And Non Hypertensive Human Placenta In Pregnancy

  • Tilak Raj
  • Pawan Kumar Mahato
  • Husnuma
  • Anand Kumar Singh
Keywords: Hypertensive Disorders, Morphology, Placenta, Pregnancy

Abstract

Introduction: Hypertensive disorders are a common complication during pregnancy. A thorough macroscopic examination of the placenta can offer significant insights into the prenatal health of both the baby and the mother.

Objectives:To compare the morphological changes in the placenta between hypertensive and normotensive pregnant mothers.

Methods: This study was conducted as an Observational Prospective Cohort Study. Detailed clinical histories were obtained, and placentas were collected from 40 hypertensive and 40 normotensive mothers who delivered in the labor room or operation theatre.Macroscopic examinations were performed, and the findings were recorded and analyzed statistically.

Results: The comparison of placental diameter, thickness, mean weight, volume, and surface area between the hypertensive and normotensive groups showed a statistically significant difference (p < 0.05).

Conclusion: Hypertensive disorders in pregnancy are reflected in the gross and microscopic findings of the placenta, which may have implications for the management of both the mother and fetus.

Author Biographies

Tilak Raj

Research Scholar Department of Anatomy, Index Medical College, Indore, M.P

Pawan Kumar Mahato

Professor Department of Anatomy, SSIMS, Bhilai Chhattisgarh

Husnuma

Tutor Department of Anatomy, Dr. K.N. Singh Memorial Institute of Medical Sciences, Barabanki, U.P

Anand Kumar Singh

Associate Professor Department of Anatomy, Dr. K.N.Singh Memorial Institute Of Medical Sciences, Barabanki. U.P

References

1. Roberts JM, Pearson G, Cutler J, et al. Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy. Hypertension. 2003 Mar; 41(3): 437-45. Epub 2003 Feb 10. DOI:10. 1161/01. HYP.000005 4981. 03589.E9
2. Barton JR, O'brien JM, et al. Mild gestational hypertension remote from term: progression and outcome. Am J Obstet Gynecol. 2001 Apr;184(5):979 83. DOI:10.1067/mob.2001.112905
3. Salgado SS, Pathmeswaran A. Effects of placental infarctions on the fetal outcome in pregnancies complicated by hypertension. J Coll Physicians Surg Pak. 2008 Apr;18 (4):213-6. doi: 04.2008/JCPSP. 213216.
4. Udainia A, Jain ML. Morphological study of placenta in pregnancy induced hypertension with its clinical relevance. Journal of the Anatomical Society of India. 2001 Jun; 50(1): 24-7.
5. Udainia A. Bhagwat SS, Mehta CD. Relation between placental surface area, infarction and foetal distress in pregnancy induced hypertension with its clinical relevance. J Anat. Soc. Ind 2004; 53(1): 27-30. 6. Browne JC, Veall N. The maternal placental blood flow in normotensive and hypertensive women. J ObstetGynaecol Br Emp. 1953 Apr;60(2):141-7.
6. Landesman R, Douglas RG, Holze E. The bulbar conjunctival vascular bed in the toxemias of pregnancy. Am J Obstet Gynecol. 1954 Jul;68(1):170-83. DOI:10.1016/0002-9378(54)90476-7
7. Thomson AM, Billewicz WZ, Hytten FE. The weight of the placenta in relation to birthweight. J ObstetGynaecol Br Commonw. 1969 Oct;76(10):865-72.
8. Stock MK, Anderson DF, Phernetton TM, et al. Vascular response of the fetal placenta to local occlusion of the maternal placental vasculature. J Dev Physiol. 1980 Oct;2(5):339-46.
9. Majumdar S, Dusguspta H, Bhattacharya K, Bhattcharya A. A study of placenta in normal & hypertensive pregnancies. J Anat. Soc. India 2005; 54(2): 1-9.
10. Wentworth P. Placental infarction and toxemia of pregnancy. Am J Obstet Gynecol. 1967 Oct 1;99(3):318-26. DOI:10.1016/s0002-9378(16)34537-9
11. Joseph F Yetter III. Col, MC, USA, ‘American family Physician’ march 1998; Vol. 57 / No. 5 Published by American Academy Of Family Physician.
12. Benirschk. American Journal of Obstetrics and Gynaecology .1,New York 961;84:1595.
13. Shah R K et al. Journal of Obstetrics and Gynecology of India 1985;35:1809.
14. Shanklin D R. Journal of Obstetrics and Gynecology of the British Commonwealth 1958; 11: 129.
15. Patricia C. Gray’s Anatomy. 38th ed. New York: Churchill Livingstone,
16. Damania KR, Salvi VS, Ratnaparki SK, Daftari SN. The placenta in hypertensive disorder in pregnancy. J Obst and Gynaecol Ind 1989; 39: 28-31.
17. Fox H; The placenta in intra uterine growth retardation. In Ward RHT, Smith SK, Donnai D (Eds). Early foetal growth and development. RCOG Press, London: 1994. p. 223-235.
18. Kalousek DK, Langlosis S. The effects of placental and somatic chromosomal mosaicism on foetal growth. In. Ward RHT, Smith SK, Donnai (eds), Early foetal growth and development, RCOG Press; 1994. p. 245 256.
19. Mardi K, Sharma J. Histopathological evaluation of placentas in IUGR pregnancies. Indian J PatholMicrobiol. 2003 Oct;46(4):551-4.
20. Salgado SS, Angunawela P, Sirisena J, De Tissera A. Villous syncytial knots in hypertensive placentae. Sri Lanka J ObstetGynaecol 2004; 26:33-7.
21. Fox H. Pathology of the Placenta. 2nd ed. W B: Saunders, London; 1997a
22. Benirschke K & Kaufmann P. ‘Pathology of Human Placenta’. 2nd ed. Newyork: Springer Verlag;1990. P. 130.
23. Soma H, Yoshida K, Mukaida T, et al. Morphologic changes in the hypertensive placenta. ContribGynecol Obstet. 1982;9:58-75.
24. Jones CJP, Fox H. An ultrastructural and ultrahistochemical study of the human placenta in maternal pre-eclampsia. Placenta 1980; 1:61-76.
25. Damjanov I, Linder J. Andersons Pathology.10th ed. New York: Mosby; 1906. p. 2321.
26. Tinney B Parker F. The placenta in Toxaemia of pregnancy. AmJObstetGynecol 1940; 39: 1000-1005.
Published
2024-10-07
How to Cite
Tilak Raj, Pawan Kumar Mahato, Husnuma, & Anand Kumar Singh. (2024). Comparative Morphological Study Of Hypertensive And Non Hypertensive Human Placenta In Pregnancy. Revista Electronica De Veterinaria, 25(1), 2251-2255. https://doi.org/10.69980/redvet.v25i1.1142
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Articles