Synthesis And In Vitro Biological Evaluation Of Metal Complexes Of 2-Aminobenzothiazole

  • Minakshi Kumari
  • Priya Saini
  • Mohd Hussain
  • Mamta Khatak
  • Bhoj Raj
  • Sudhir Kaushik
  • Sudhir Kaushik
  • Mahesh Kumar
Keywords: 2-aminobenzothiazole, Schiff base, metal complexes, spectral analysis, biological evaluation and antioxidant activity


Antibiotic resistance is a growing problem in today’s healthcare which increase the demand of heterocyclic compounds. Heterocyclic compound bears different biological activity, like anti-cancer, anti-inflammatory, anti-oxidant, antibacterial, etc. therefor its demand increase in development of new compounds to overcome microbial resistance. The coordination chemistry of 2-aminobenzothiazole, which possesses potential coordinating sites including one exocyclic (NH2) and two endocyclic (N and S), has received significant attention in recent decades. The interest has led to the discovery of various transition metal complexes exhibiting diverse structures. 2-amino benzothiazole and substituted aldehyde (2,4 dichlorbenzaldehyde ,4-benzyloxybenzaldehyde) used as a reactant in synthetic organic chemistry and also used for making Schiff base ligand for increase the potency of the final product. The reaction of the Schiff bases (SB1 and SB2) with the core metals like Cobalt chloride, manganese chloride, nickel chloride, and copper (II) has produced metal complexes (MC1-8) of Schiff bases. In our study, we employed the DPPH assay and the agar diffusion method to assess the anti-oxidant and antimicrobial characteristics of the synthesized ligands and their metal complexes

Author Biographies

Minakshi Kumari

Research Scholar, Department of Pharmaceutical Sciences, MDU Rohtak

Priya Saini

Research Scholar, Department of Pharmaceutical Sciences, MDU Rohtak

Mohd Hussain

Research Scholar, Department of Pharmaceutical Sciences, MDU Rohtak

Mamta Khatak

Assistant Professor, BM group of Institution, Frukhnagar, Gurugram

Bhoj Raj

Research Scholar, Department of Pharmaceutical Sciences, MDU

Sudhir Kaushik

Research Scholar, Department of Pharmaceutical Sciences, MDU Rohtak

Sudhir Kaushik

Assistant Professor MVN University, Palwal

Mahesh Kumar

Associate Professor Department of Pharmaceutical Sciences, MDU Rohtak



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How to Cite
Minakshi Kumari, Priya Saini, Mohd Hussain, Mamta Khatak, Bhoj Raj, Sudhir Kaushik, Sudhir Kaushik, & Mahesh Kumar. (2024). Synthesis And In Vitro Biological Evaluation Of Metal Complexes Of 2-Aminobenzothiazole. Revista Electronica De Veterinaria, 25(1S), 5-11. Retrieved from