Immunoglobulins and Visceral Gout in Chickens: An In-Depth Treatment Assessment
Abstract
The immune system's essential components, immunoglobulins, have been examined in relation to immunological responses. The precise immunomodulatory impact of immunoglobulins on visceral gout remains unclear despite their well-established involvement in immunity. This study clarifies the function immunoglobulins perform in the underappreciated immunomodulatory context of visceral gout in broiler chicks. 150 broiler chicks with clinical indications of visceral gout were split into two categories, Category 1 was the untreated control group and Category 2 had intramuscular injections of immunoglobulin. Mortality rates, body mass and metabolic markers were observed for six weeks. As a result of receiving immunoglobulin treatment, the afflicted chicks' body mass increased, uric acid (UA) and gamma-glutamyl transferase (GGT) levels decreased and mortality was considerably reduced. The results demonstrate immunoglobulin delivery as a potential treatment method that could reduce the severity of visceral gout in broiler chicks.
References
Vinkler, M., Adelman, J. S., & Ardia, D. R. (2022). Evolutionary and ecological immunology. In Avian immunology (pp. 519-557). Academic Press. https://doi.org/10.1016/B978-0-12-818708-1.00008-7.
Yvernogeau, L., Nagy, N., Dunon, D., Robin, C., & Jaffredo, T. (2022). Development of the avian hematopoietic and immune systems. In Avian Immunology (pp. 45-69). Academic Press. https://doi.org/10.1016/B978-0-12-818708-1.00031-2.
Jia, M. (2021). Effect of probiotics or high incubation temperature on gene expression and cell organization of the small intestine and yolk sac of chicks (Doctoral dissertation, Virginia Tech).
Kumar, S., Gupta, M. K., Kumar, S., & Rana, T. (2023). Comparative studies of xanthine oxidase inhibitors viz. allopurinol and febuxostat against induced hyperuricaemia in a poultry model. Avian Pathology, 1-10. https://doi.org/10.1080/03079457.2023.2276142.
Pan, X., Su, X., Ding, P., Zhao, J., Cui, H., Yan, D., ... & Li, Z. (2022). Maternal-derived antibodies hinder the antibody response to H9N2 AIV inactivated vaccine in the field. Animal Diseases, 2(1), 9. https://doi.org/10.1186/s44149-022-00040-0.
Palinauskas, V., Mateos-Hernandez, L., Wu-Chuang, A., de la Fuente, J., Aželytė, J., Obregon, D., & Cabezas-Cruz, A. (2022). Exploring the ecological implications of microbiota diversity in birds: Natural barriers against avian malaria. Frontiers in immunology, 13, 807682. https://doi.org/10.3389/fimmu.2022.807682.
Żymańczyk-Duda, E., Samson, S. O., Brzezińska-Rodak, M., & Klimek-Ochab, M. (2022). Versatile applications of cyanobacteria in biotechnology. Microorganisms, 10(12), 2318. https://doi.org/10.3390/microorganisms10122318.
Chechet, O. M., Kovalenko, V. L., Vishchur, O. I., Haidei, O. S., Liniichuk, N. V., Gutyj, B. V., & Krushelnytska, O. V. (2022). The activity of Tand B-cell links of specific protection of chicken-broilers under the influence of synbiotic preparation “Biomagn” and “Diolide” disinfectant. Ukrainian journal of veterinary and agricultural sciences, 5(1), 46-52. https://doi.org/10.32718/ujvas5-1.08.
Maslanka, M. T., Frye, F. L., Henry, B. A., & Augustine, L. (2023). Nutritional Considerations. In Health and welfare of captive reptiles (pp. 447-485). Cham: Springer International Publishing. https://doi.org/10.1007/978-3-030-86012-7_14.
Dakhil, A. J., & Al-Shammari, K. I. A. (2023, August). Effect of Dietary Fenugreek Seeds and Synbiotic on the Physiological Anatomical, Immunological Attributes and Antioxidant Status in Stressed Chickens. In IOP Conference Series: Earth and Environmental Science (Vol. 1225, No. 1, p. 012047). IOP Publishing. https://doi.org/10.1088/1755-1315/1225/1/012047.
Xi, Y., Huang, Y., Li, Y., Huang, Y., Yan, J., & Shi, Z. (2022). The effects of dietary protein and fiber levels on growth performance, gout occurrence, intestinal microbial communities, and immunoregulation in the gut-kidney axis of goslings. Poultry Science, 101(5), 101780. https://doi.org/10.1016/j.psj.2022.101780.
Timurkaan, N., ÖNGÖR, H., Kalender, H., Karabulut, B., ÇÖVEN, F., ÇEVİK, A., ... & Cetinkaya, B. (2023). Pathological and molecular findings of visceral gout caused by Israel variant 2 (IS/1494/06) genotype of infectious bronchitis virus in chickens. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 70(2), 149-156. https://doi.org/10.33988/auvfd.974221.
Li, J. Y., Hu, W. Q., Liu, T. N., Zhang, H. H., Opriessnig, T., & Xiao, C. T. (2021). Isolation and evolutionary analyses of gout-associated goose astrovirus causing disease in experimentally infected chickens. Poultry Science, 100(2), 543. https://doi.org/10.1016%2Fj.psj.2020.11.003.
Xi, Y., Huang, Y., Li, Y., Yan, J., & Shi, Z. (2020). Fermented feed supplement relieves caecal microbiota dysbiosis and kidney injury caused by high-protein diet in the development of gosling gout. Animals, 10(11), 2139. https://doi.org/10.3390/ani10112139.
Raji, A. A., & Omar, A. R. (2022). An insight into the molecular characteristics and associated pathology of chicken astroviruses. Viruses, 14(4), 722. https://doi.org/10.3390/v14040722.
Zhou, Q., Cui, Y., Wang, C., Wu, H., Xiong, H., Qi, K., & Liu, H. (2023). Characterisation of natural co-infection with Goose astrovirus genotypes I and II in gout affected goslings. Avian Pathology, (just-accepted), 1-24. https://doi.org/10.1080/03079457.2023.2295341.
Wang, A., Xie, J., Wu, Z., Liu, L., Wu, S., Feng, Q., ... & Zhu, S. (2023). Pathogenicity of a goose astrovirus 2 strain causing fatal gout in goslings. Microbial Pathogenesis, 184, 106341. https://doi.org/10.1016/j.micpath.2023.106341.
Zhang, Q., Cao, Y., Wang, J., Fu, G., Sun, M., Zhang, L., ... & Su, J. (2018). Isolation and characterization of an astrovirus causing fatal visceral gout in domestic goslings. Emerging Microbes & Infections, 7(1), 1-11. https://doi.org/10.1038/s41426-018-0074-5.
Liu, H., Hu, D., Zhu, Y., Xiong, H., Lv, X., Wei, C., ... & Wang, G. (2020). Coinfection of parvovirus and astrovirus in gout‐affected goslings. Transboundary and Emerging Diseases, 67(6), 2830-2838. https://doi.org/10.1111/tbed.13652.
Raji, A. A., Ideris, A., Bejo, M. H., & Omar, A. R. (2022). Molecular characterization and pathogenicity of novel Malaysian chicken astrovirus isolates. Avian Pathology, 51(1), 51-65. https://doi.org/10.1080/03079457.2021.2000939.
