The Protective Role of Red Algae Hot-Water Extract on Lipid Metabolism in Hamsters with High-Fat Diet
Abstract
The purpose of the investigation was to examine how Gelidium amansii (GA) hot-water extracts (GHWE) affected fat utilization in hamsters. The male Syrian hamsters were separated into four categories for the research: a control diet category, a high-fat diet category, a high-fat diet supplement with GHWE, and a high-fat diet supplement with probucol. For a period of six weeks, field-testing meals were provided to the hamsters and multiple factors were monitored. GHWE treatment resulted in substantial reductions in the body's mass, liver mass, and fat tissue mass, according to the findings. The high-fat diet increased overall cholesterol (OC), plasma neutral fats (NF), LDLP-CH, and very LDLP-CH amounts. GHWE supplements, on the other hand, restored these fat deficiencies caused by the high-fat diet. GHWE also enhanced faecal cholesterol levels, NF, and bile acid elimination GHWE therapy also reduced hepatic OC and NF concentrations. It also looked into the molecular processes behind these impacts. GHWE therapy lowered the protein production of hepatic sterol regulatory element-binding proteins (SREBPs), consisting of SREBP 1 and SREBP 2. Furthermore, GHWE supplements boosted the glycosylation of AMP-activated protein kinase (AMPK) protein production which was inhibited by high-fat nutrition.
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