Hematological, Biochemical, and Histological Measures in Wistar Male Rats used to Assess Asafetida's Toxicity

  • Puja Lal Lecturer, Department of Pharmacy, Usha Martin University, Ranchi- Jharkhand
  • Dechen Ganjur Assistant Professor, Department of Pharmacy, Himalayan University, Itanagar-Arunachal Pradesh
  • Abdul Wadood Siddiqui Professor, Department of Pharmacy, Mangalayatan University, Aligarh, Uttar Pradesh
  • Pranal Chhetri Assistant Professor, Collage of Pharmacy, Sikkim Professional University, Gangtok, Sikkim
Keywords: liver, Asafetida, kidney, toxicity, hematology

Abstract

Traditional uses of asafetida in folk medicine include the alleviation of a wide range of symptoms. A proper assessment of its toxicity in the animal system is necessary to back up its usage in conventional medicine. Asafetida was tested for its toxicity in Wistar albino rats in order to draw conclusions about its safety for human consumption. Tools and Techniques: Animals were given oral doses of different mg/kg of body weight to test for acute toxicity. Asafetida was given to animals at several dosages of mg/kg body weight) during the course of a 6-week chronic trial. Asafetida's effects on renal,haematological, and histological indicators and hepatic measures were assessed at the study's conclusion. There was no fatality seen in the acute toxicity trial for asafetida up to 72 hours after dosing. Within 24 hours, no noticeable neurological or behavioural abnormalities were seen. In the long-term trial, asafetida consumption altered haematological markers including platelets, RBC, WBC, andHCT. The enzymes lactate dehydrogenase (LDH) and aspartate aminotransferase (AST)were both considerably elevated in the treated animals. At no point throughout the research did asafetida treatment cause a change in plasma urea or creatinine levels. Hepatotoxicity was found by histopathology analysis, although significant kidney pathological alterations were not. We conclude that asafetida is safe for short-term use, but that long-term use may have unfavourable effects on hepatocytes and haematological parameters.

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Published
2022-11-25
How to Cite
Puja Lal, Dechen Ganjur, Abdul Wadood Siddiqui, & Pranal Chhetri. (2022). Hematological, Biochemical, and Histological Measures in Wistar Male Rats used to Assess Asafetida’s Toxicity. Revista Electronica De Veterinaria, 23(4), 53 - 57. Retrieved from https://www.veterinaria.org/index.php/REDVET/article/view/274