A Research on a Few Oral Hypoglycemic Medications to Stop the Growth of Diabetes Problems in Lab Animals

  • Richa Lecturer, Department of Pharmacy, Usha Martin University, Ranchi- Jharkhand
  • Barun Ranjan Sarkar Assistant Professor, Department of Pharmacy, Himalayan University, Itanagar-Arunachal Pradesh
  • Jyoti Singh Jatav Assistant Professor, Department of Pharmacy, Mangalayatan University, Aligarh, Uttar Pradesh
  • Sabina Gurung Assistant Professor, Collage of Pharmacy, Sikkim Professional University, Gangtok, Sikkim
Keywords: type II diabetes, hyperglycemia, Diabetes mellitus, chronic metabolic disorder, hypertension, cardiac dysrhythmias

Abstract

Hyperglycemia is the defining feature of diabetes mellitus (also known as DM), which is a persistent metabolic condition. A deficiency in insulin production (type I) or insulin secretion (type II), together with resistance to the effect of insulin, or a combination of both of these variables, can lead to this syndrome. It is a condition that affects people of all ages, both sexes, and all races equally all over the world. It is a disorder that necessitates the medication-based careful management of one's glucose levels. A dangerously high level of elevated blood glucose (hyperglycemia) can lead to diabetic ketoacidosis, which in turn can cause coma and ultimately death. In a similar vein, low blood glucose, also known as hypoglycemia, can result in a coma and ultimately death. Because of this, it is necessary for the drugs to carefully manage the patient's blood glucose levels. [Cerveny JD et al., 1998] found that people with type II diabetes were more prevalent than those with type I diabetes. Insulin is helpful for diabetics who have type I diabetes. Gliclazide is one of the most commonly prescribed drugs in the category of sulfonylureas, which medications are considered to be the most effective in treating type II diabetes? The medicine Gliclazide served as the benchmark in this particular investigation. Chronic diabetes, if uncontrolled, can lead to a number of consequences, including cardiac difficulties such as angina, hypertension, cardiac dysrhythmias, and renal failure [Cerveny JD et al., 1998]. These complications are the major causes of death in chronic diabetes [Cerveny JD et al., 1998]. [Cerveny JD et al., 1998] The development of various problems, including heart issues such as angina, hypertension, and cardiac dysrhythmia, can be attributed to the presence of diabetes that is chronic.

References

Unger RH. Grundy Hyperglycemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes. Diabetologia. 1985; 28: 119-121

IDF Diabetes Atlas, International diabetes federation. 6th Edition, 2013

Xing XH, Zhang ZM, Hu XZ, Wu RQ, Xu C. Antidiabetic effects of Artemisia sphaerocephalaKrasch. gum, a novel food additive in China, on streptozotocin-induced type 2 diabetic rats. J Ethnopharmacol. 2009; 125(3):410-6

Prout TE. In: Malaisse WJ, Pirart J. Procedings (VIII) of Congress of International Diabetes Federation. Excerptamedica. 1974; 162

American Geriatrics Society Beers Criteria Update Expert Panel (2012). "American Geriatrics Society Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults". J Am Geriatr Soc. 2012; 60 (4): 616–31.

Baldessarini Ross J, Frank I. Tarazi Pharmacotherapy of Psychosis and Maa. In Laurence Brunton, John Lazo, Keith Parker (eds.). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11th ed.), 2006

Campbell DB, Lavielle R & Nathan C: The mode of action and clinical pharmacology of gliclazide: a review. Diabetes Res ClinPract. 1991; 14(2):21-36.

De Groot M, Anderson R, Freedland KE, Clouse RE, Lustman PJ: Association of depression and diabetes complications: a meta-analysis. Psychosom Med. 2001; 63 : 619-630.

Wirshing DA, Wirshing WC, Kysar L, Berisford MA. Novel antipsychotics: comparison of weight gain liabilities. J Clin Psychol. 1999; 60 (6): 358–63.

Xing XH, Zhang ZM, Hu XZ, Wu RQ, Xu C. Antidiabetic effects of Artemisia sphaerocephalaKrasch. gum, a novel food additive in China, on streptozotocin-induced type 2 diabetic rats. J Ethnopharmacol. 2009; 125(3):410-6

Yoon JW and Baek HS. Role of macrophages in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice. J Virol. 1990 Dec; 64(12): 5708–5715.

Published
2022-11-25
How to Cite
Richa, Barun Ranjan Sarkar, Jyoti Singh Jatav, & Sabina Gurung. (2022). A Research on a Few Oral Hypoglycemic Medications to Stop the Growth of Diabetes Problems in Lab Animals. Revista Electronica De Veterinaria, 23(4), 47 - 52. Retrieved from https://www.veterinaria.org/index.php/REDVET/article/view/273