Anti-Inflammatory Potential Of Green Synthesized Magnesium Oxide From Tamarindus Indica
Abstract
The development of biocompatible and eco-friendly nanomaterials is a primary objective in contemporary nanomedicine. This study reports the successful green synthesis of magnesium oxide nanoparticles (MgONPs) using the aqueous leaf extract of Tamarindus indica as a potent bioreducing and stabilizing agent. The biosynthesized MgONPs were characterized using UV-Vis spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy, X-ray Diffraction (XRD), and Field Emission Scanning Electron Microscopy (FESEM) coupled with Energy Dispersive X-ray (EDX) analysis. UV-Vis spectra confirmed the formation of MgONPs with a characteristic surface plasmon resonance peak at 284 nm. XRD analysis revealed a highly crystalline, face-centered cubic structure with an average crystallite size of 22.4 nm. FTIR results confirmed the presence of polyphenolic and flavonoid functional groups on the nanoparticle surface, facilitating their stability. The in vitro anti-inflammatory potential was evaluated using the bovine serum albumin (BSA) denaturation assay. The green-synthesized MgONPs exhibited significant dose-dependent anti-inflammatory activity, achieving a maximum inhibition of 83.2% at 100 µg/mL (IC50 = 49.6 µg/mL), which was comparable to the standard drug Ibuprofen (IC50 = 38.2 µg/mL). These findings suggest that T. indica-mediated MgONPs serve as a promising, sustainable, and bioactive alternative for the management of inflammatory conditions.
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