Formulation And Validation of Controlled Release Ocular Inserts of Selected Gatifloxacin Antibiotic Drug

Abstract

Ophthalmic drug delivery is one of the most interesting and challenging endeavors facing the pharmaceutical scientists. The anatomy-physiology^{1, 2} and biochemistry of the eye render this organ exquisitely impervious to foreign substances. The challenge to the formulation is to circumvent the protective barriers of the eye without causing permanent tissue damage. The development of newer, more sensitive diagnostic techniques and therapeutic agents renders urgency to the development of maximum successful and advanced ocular drug delivery systems. The goal of pharmacotherapeutics is the attainment of an effective drug concentration at the intended site of action for a desired period of time. Eye, as a portal for drug delivery is generally used for the local therapy as against systemic therapy in order to avoid the risk of eye damage from high blood concentrations of drug which are not intended for eye.