Solubility Enhancement of Simvastatin Drug by Using Different Technology And Β-Cyclodextrin (Β-CD) And Chitosan (Chitosan) Polymers
Abstract
In the current study, inclusion complexes of simvastatin using β-cyclodextrin (β-CD) and chitosan (chitosan) through three different techniques: physical mixing, kneading, and spray drying. These complexes were formulated in drug-to-cyclodextrin molar ratios of 1:1 and 1:2. All formulations underwent in vitro evaluation. The resulting inclusion complexes appeared white, fine, and non-sticky in texture. Among the different methods, the kneading and spray drying approaches with chitosan (1:1 molar ratio) showed superior drug release compared to the pure drug. Likewise, the physical mixture of simvastatin with β-CD at a 1:2 molar ratio demonstrated improved dissolution. Kinetic analysis revealed that the drug release followed first-order kinetics rather than zero-order. In summary, the findings suggest that both β-CD and chitosan are promising carriers for enhancing the solubility and dissolution rate of simvastatin, making them suitable for formulating fast-release drug delivery systems.
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