Current Insights On The Therapeutic Potentials Of Aplysia Species, A Unique Marine Bioresource For Bioactive Molecules- A Minireview
Keywords:
Marine pharmacology, Anticancer agents, Neuroprotective compounds, Marine Bioactive compounds, Drug discovery
Abstract
Notably, the marine mollusk Aplysia species were commonly referred as the sea hare by malacologists has now emerged as a significant bioresource for the discovery of novel bioactive compounds with significant therapeutic potential. This mini-review emphasizes the diverse secondary metabolites isolated from Aplysia species, including alkaloids, terpenoids, peptides and proteins, which exhibit antimicrobial, anticancer, anti-inflammatory and neuroprotective properties. Especially, Aplysia secretions and egg masses contain unique molecules such as aplysiatoxins, kahalalides and lectins, which have demonstrated promise in drug development. For instance, Kahalalide F has progressed to clinical trials as a potential anticancer agent, while derivatives of aplysiatoxin exhibit potent modulation of protein kinase C. Furthermore, neurons of Aplysia serve as a model system in neurobiological research, contributing to advancements in studies of synaptic plasticity and memory. Despite their pharmacological potential, challenges such as sustainable sourcing, compound stability and toxicity profiling persist. Recent advances in marine biotechnology, including aquaculture and synthetic biology, may address these limitations, facilitating the scalable production of Aplysia-derived therapeutics. Thereby, this review would surely underscore the importance of further exploration into Aplysia-derived bioactive molecules, highlighting their role in future drug discovery and biomedical applications.
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11. Chency grace o. liguez1 and Sharon rose tabugo1,2 Antibacterial activity of sea hare (Dolabella auricularia) egg string extracts against potentially pathogenic bacteria. 2023, Volume 24, Number 12, December 2023, Pages: 6675-6683, E-ISSN: 2085-4722.
12. Ciavatta, M. L., Lefranc, F., Carbone, M., Mollo, E., Gavagnin, M., & Kiss, R. (2017). Marine mollusk-derived agents with antiproliferative activity as promising anticancer agents. Marine Drugs, 15(10), 310. https://doi.org/10.3390/md15100310
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14. Dirrigl Jr, Frank J., et al., "Use of the sea hare (Aplysia fasciata) in marine pollution biomonitoring of harbors and bays." Marine Pollution Bulletin 129.2 (2018): 681-688. https://doi.org/10.1016/j.marpolbul.2017.10.056
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18. Fujiki, H., Sueoka, E., & Suganuma, M. (2018). Tumor promotion by inhibitors of protein phosphatases 1 and 2A: The okadaic acid class of compounds. Advances in Cancer Research, 117, 1-32. https://doi.org/10.1016/B978-0-12-394274-6.00001-5
19. Fujiki, H., Sueoka, E., & Suganuma, M. (2021). Protein kinase C modulators from marine sources. Advances in Cancer Research, *152*, 1-38. https://doi.org/10.1016/bs.acr.2021.03.001
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How to Cite
S.Tamil selvi, K.Bhanumathi, & M.Sasirekhamani. (1). Current Insights On The Therapeutic Potentials Of Aplysia Species, A Unique Marine Bioresource For Bioactive Molecules- A Minireview. Revista Electronica De Veterinaria, 25(2), 1637-1647. https://doi.org/10.69980/redvet.v25i2.1925
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