Anticancer Potential of potent extracts of Bergenia stracheyi
Keywords:
Anticancer potential, Bergenia stracheyi, solvent extracts, hepatic cancer cell lines
Abstract
Medicinal plants have been a valuable source of natural products for maintaining human health, especially in the last decade, with more intensive studies for natural therapies. Many plants have been used because of their pharmacological traits, which are due to compounds synthesized in the secondary metabolism of the plant. In the present study, Bergenia stracheyi solvent extracts were screened for anticancer potential against liver (hep-2) cancer cell lines. it was observed that, liver (hep-2) cell line showed 65.78 % cell viability after treatment with Bergenia stracheyi hydro-alcoholic extract (20µg/ml) as determined by Trypan blue dye exclusion technique. The cytotoxicity assay of the Bergenia stracheyi hydro-alcoholic extract was determined against liver (hep-2) cell line, 50% cyto-toxicity was observed in 20 µg/ml with respect to hepatic cancer cell line studied. The standard positive drug viz. cyclophosphamide monohydrate showed 50% cyto-toxicity at 10 µg/ml against liver (hep-2) cell line. Thus, the IC50 value of the Bergenia stracheyi hydro-alcoholic extract was found to be 20µg/ml against hepatic cancer cell lines and IC50 values of cyclophosphamide monohydrate was found to be 10 µg/ml against liver (hep-2) cell line. The Bergenia stracheyi hydro-alcoholic extract (20µg/ml) was screened against cancer cell lines viz. liver (hep-2) cell line respectively via Sulphorodamine B assay and Microculture tetrazolium (MTT) assay. It was found that the extract was effective against hepatic cancer cell lines studied. It was found that the results of both the tests viz. Sulphorodamine B and MTT assay are correlated to each other. It was found that, the Bergenia stracheyi hydro-alcoholic extract (20µg/ml) causes 72.56 % inhibition of cancer cells in liver (hep-2) cancer cell line as observed by Sulphorodamine B assay.References
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[3] Gonelimali FD, Lin J, Miao W, Xuan J, Charles F, Chen M, Hatab SR. Antimicrobial properties and mechanism of action of some plant extracts against food pathogens and spoilage microorganisms. Frontiers of Microbiology 2018; 1-6.
[4] Eloff JN, Elisha IL, Botha FS, Mc Gaw LJ. The antibacterial activity of extracts of nine plant species with good activity against E. coli against five other bacteria and cytotoxicity of extracts 2017; 17: 133.
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[7] Benkeblia N. Antimicrobial activity of essential oil extract of various onions and garlic. Lebenson Wiss-U Technology 2004; 37, 263-268.
[8] Bylka W, Szauffer-Hajjdrych M, Matlawaska I, Goslinska O. Antimicrobial activity of isocytisoside and extracts of Aquilegia vulgaris. Letters in Applied Microbiology 2004; 39, 93–97.
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Published
2024-09-17
How to Cite
Sandeep Chauhan, Abhishek Mathur, & Simran Dhiman. (2024). Anticancer Potential of potent extracts of Bergenia stracheyi. Revista Electronica De Veterinaria, 25(2), 1394 - 1397. https://doi.org/10.69980/redvet.v25i2.1818
Section
Articles
