"Exploring the Role of Traditional Indian Medicine in the Green Synthesis of Biomedical Nanoparticles"
Abstract
In recent years, nanoparticles have gained significant importance due to their application through green synthesis, which has become one of the most specific methods. Green synthesis of nanoparticles is a new branch of nanotechnology. Traditionally, Indians have used herbal drugs because of their efficacy and minimal side effects, making them safe for the human body. For centuries, herbal medicines have been manufactured on a large scale, contributing to India's wealth of well-documented traditional knowledge systems, such as Ayurveda, Yoga, Unani, Siddha, Homeopathy, and Naturopathy. In Ayurveda, medicinal plants have played a significant role since ancient times. Parts of medicinal plants and their products are inexpensive sources for Indian Ayurvedic medicines. Various plants and their derivatives are vital subjects of research in contemporary nanobiotechnology, particularly in nanoparticle synthesis. This green synthesis method serves as an alternative to chemical methods, as it is cost-effective, non-polluting, and eco-friendly. Nanoparticles (NPs), typically less than 100 nm in size, are integral to nanotechnology, the study of objects on this scale. Notable nanoparticles include those made of silver, platinum, and gold, which have significant applications in fields like optoelectronics, electronics, magnetics, and information storage. Gold-Silver Nanoparticles are of particular interest in research due to their impact on chemical, electronic, energy, space, and pharmaceutical industries. Nanotechnology encompasses the characterization, manufacture, and manipulative uses of nanoparticles, offering a new frontier for material science. The small size and unique chemical, physical, and biological properties of nanoparticles make them crucial in various scientific domains. Recently, metal nanoparticles have garnered attention for their diverse applications, especially in biomedical areas such as targeted drug delivery, imaging, sensing, and antimicrobial activity.
References
2. Amalray, A. and Gopi, S. 2017. Biological activities of Curcuminoidsother biomolecules from turmeric and derivalives J. of Traditional and Complementary Medicine 7(2): 205-233.
3. Bhattacharya, D. and Rajinder, G. 2005. Nanotechnology and potential of microorganism. Critical Reviews in Biotechnology. 25: 199-204. Braydich-Stolle, L., Hussain, S., Schlager, J.J. and Hofmann, M.C. 2005. In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol, Sci. 88: 412-419.
4. Gardea–Torressdey, J.L., Tiemann, K.J., Gamez, G., Dokken, L., Tehuacanero, S. and Jose–Yacaman, M. 1999. Gold nanoparticles obtained by bio-precipition from gold (III) solution. J. Nanopart. Res. 1(3): 397- 404
5. Kulharni, P.A., Srivastava, A.A., Harpale, P.M. and Zunjarrao, R.S. 2011. Green synthesis of silver nanoparticles using leaf extract of Mangifera indica and evaluation of their antimicrobial activity. J. Nat. Plant Rsour. 1(4): 100- 107.
6. Lin, L., Wang, W., Huang J., Li, Q., Sun, D., Yang, X., Wang, H., He, N. and Wang, Y. 2010. Nature factory of silver nanowires: plant-mediated synthesis using broth of Cassia fistula leaf. Chemical Engineering Journal. 162(2): 852-858.
7. Nager, N., Jain, S., Kachhawah, P. and Devra, V. 2016. Synthesis and characterization of silver Nanoparticles via green route. Korean. J. Chem. Eng. 33 (10): 2990-2997.
8. Raveendran, P., Fu, J. and Wallen, J.S.L. 2003. Completely “green” synthesis and stabilization of metal nanoparticles. J. Am. Chem. Soc. 125 : 13940-13941.
9. Balantrapu K, Goia DV (2009) Silver nanoparticles for printable electronics and biological applications. J Mater Res 24:2828–2836.
10. Banasiuk R, Krychowiak M, Swigon D et al (2020) Carnivorous plants used for green synthesis of silver nanoparticles with broad-spectrum antimicrobial activity. Arab J Chem. https://doi. org/10.1016/j.arabjc.2017.11.013
11. Bar H, Bhui DK, Sahoo GP et al (2009) Green synthesis of silver nanoparticles using seed extract of Jatropha curcas. Colloids Surfaces A Physicochem Eng Asp. https://doi.org/10.1016/j.colsu rfa.2009.07.021
12. Boomi P, Poorani GP, Selvam S et al (2020) Green biosynthesis of gold nanoparticles using Croton sparsiforus leaves extract and evaluation of UV protection, antibacterial and anticancer applications. Appl Organomet Chem. https://doi.org/10.1002/aoc.5574
13. Chandran SP, Chaudhary M, Pasricha R et al (2006a) Synthesis of gold nanotriangles and silver nanoparticles using Aloe vera plant extract. Biotechnol Prog. https://doi.org/10.1021/bp0501423
14. Azam, A. 2019. Path of Green Chemistry and Sustainable development, Asian Journal of Advances in Research 2(1): ISSN No.: 2582-3248, pg. No.18–21.
15. Azam, A. Pandey A. K. 2021. Educating students about the complexity of green chemistry and Incorporating information of theoretical green chemistry courses, IJCRT, International 9(6) ISSN No.: 2320-2882, pg. No. 337-341.
16. Azam, A. et al, 2022. Importance and applications of Green Chemistry for Sustainable development, IJFANS e-ISSN NO. 2320-7846 VOL. 11,ISSUE-11:590-599(2022).
17. Azam, A. et al, 2024. "Educational Insights into the Complex Intersections of Green Chemistry and Arsenic-Induced Groundwater Pollution in Sustainable Development" International Research Journal of Innovations in Engineering and Technology (IRJIET), ISSN (online): 2581-3048, Volume 8, Issue 2, pp 45-50.
18. El-Sayed IH, Huang X, El-Sayed MA (2005) Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: applications in oral cancer. Nano Lett 5:829–834
19. Fernando SID, Judan Cruz KG (2020) Ethnobotanical biosynthesis of gold nanoparticles and its downregulation of Quorum sensinglinked AhyR gene in Aeromonas hydrophila. SN Appl Sci. https ://doi.org/10.1007/s42452-020-2368-1
20. Frey NA, Peng S, Cheng K, Sun S (2009) Magnetic nanoparticles: synthesis, functionalization, and applications in bioimaging and magnetic energy storage. Chem Soc Rev 38:2532–2542
21. Ghosh P, Han G, De M et al (2008) Gold nanoparticles in delivery applications. Adv Drug Deliv Rev 60:1307–1315
22. Ghosh NS, Pandey E, Giilhotra RM, Singh R (2020) Biosynthesis of gold nanoparticles using leaf extract of Desmodium gangeticum and their antioxidant activity. Res J Pharm Technol 13:2685–2689
23. Huang X, El-Sayed MA (2010) Gold nanoparticles: optical properties and implementations in cancer diagnosis and photothermal therapy. J Adv Res 1:13–28
24. Huang J, Lin L, Li Q et al (2008) Continuous-fow biosynthesis of silver nanoparticles by lixivium of sundried Cinnamomum camphora leaf in tubular microreactors. Ind Eng Chem Res 47:6081–6090
25. Hulkoti NI, Taranath TC (2014) Biosynthesis of nanoparticles using microbes—a review. Colloids Surfaces B Biointerfaces 121:474– 483. https://doi.org/10.1016/j.colsurfb.2014.05.027
26. Iravani S (2011) Green synthesis of metal nanoparticles using plants. Green Chem 13:2638–2650. https://doi.org/10.1039/C1GC1 5386B
27. Islam NU, Jalil K, Shahid M et al (2019) Green synthesis and biological activities of gold nanoparticles functionalized with Salix alba. Arab J Chem. https://doi.org/10.1016/j.arabjc.2015.06.025
28. Jain PK, Lee KS, El-Sayed IH, El-Sayed MA (2006) Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. J Phys Chem B. https://doi.org/10.1021/jp057 170o
