A study on the Therapeutic Effects of Nigella Seeds (Kalonji)
Keywords:
Nigella Seeds, Kalonji, nigella sativa, pharmacological effects, antioxidants, anti-diabetic, anti-cancer, therapeutic properties, and medicinal advantages
Abstract
Nigella seeds, also known as Kalonji & Black cumin seed, Scientific name is Nigella Sativa, is a plant full of medicinal properties that are used all over the world and commonly found especially in most Asian countries. Nigella seeds are very famous and popular due to their medicinal properties and it have been used since ancient times in India. They are extensively used to make Ayurvedic, Tibetan, and Unani medicines to treat many different diseases and ailments. Based on the pieces of evidence of many previous researches, it can be said that it has been used since ancient times in the treating of skin conditions as well as making liver tonics, diuretics, digestive, anti-diarrheal, appetite restorative, and palliative. Till now, there are many such types of research done on nigella seeds among the previous researches in which a lot of money was spent to test or observe its medicinal and pharmacological properties, including anti-diabetic, anti-cancer, immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, bronchodilator, hepato-protective, renal protective, gastro-protective, antioxidant properties, etc., and after all the investigation it is proved that N. Sativa is the best herbal medicine with amazing healing abilities. In addition, this also divulges that the leading bioactive component of the essential oil, thymoquinone, is the helm for the preponderance of the plant's medicinal dexterities. This present review aims to deliver an in-depth analysis of the literature on scientific investigations exploring the therapeutic benefits and medicinal advantages of the seeds of N. Sativa.
References
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2. Abukhader, M. (2013) ‘Thymoquinone in The clinical Treatment of cancer: Fact or fiction-’, Pharmacognosy Reviews, 7(14), pp. 117–120. Available at: https://doi.org/10.4103/0973-7847.120509.
3. Abulfadl, Y.S. et al. (2018) ‘Thymoquinone alleviates the experimentally induced Alzheimer’s disease inflammation by modulation of TLRs signaling’, Human & Experimental Toxicology, 37(10), pp. 1092–1104. Available at: https://doi.org/10.1177/0960327118755256.
4. Alhibshi, A.H., Odawara, A. and Suzuki, I. (2019) ‘Neuroprotective efficacy of thymoquinone against amyloid beta-induced neurotoxicity in human induced pluripotent stem cell-derived cholinergic neurons’, Biochemistry and Biophysics Reports, 17, pp. 122–126. Available at: https://doi.org/https://doi.org/10.1016/j.bbrep.2018.12.005.
5. Alkhalaf, M.I., Hussein, R.H. and Hamza, A. (2020) ‘Green synthesis of silver nanoparticles by Nigella sativa extract alleviates diabetic neuropathy through anti-inflammatory and antioxidant effects’, Saudi Journal of Biological Sciences, 27(9), pp. 2410–2419. Available at: https://doi.org/https://doi.org/10.1016/j.sjbs.2020.05.005.
6. Amin, B. and Hosseinzadeh, H. (2016) ‘Black Cumin (Nigella sativa) and Its Active Constituent, Thymoquinone: An Overview on the Analgesic and Anti-inflammatory Effects’, Planta Medica, 82(1–2), pp. 8–16. Available at: https://doi.org/10.1055/s-0035-1557838.
7. Anand David, A.V., Arulmoli, R. and Parasuraman, S. (2016) ‘Overviews of biological importance of quercetin: A bioactive flavonoid’, Pharmacognosy Reviews, 10(20), pp. 84–89. Available at: https://doi.org/10.4103/0973-7847.194044.
8. Atta, M.B. (2003) ‘Some characteristics of nigella ( Nigella sativa L .) seed cultivated in Egypt and its lipid profile’, 83, pp. 63–68. Available at: https://doi.org/10.1016/S0308-8146(03)00038-4.
9. Aziz, N. (2018) ‘Thymoquinone Suppresses IRF-3-Mediated Expression of Type I Interferons via Suppression of TBK1’, 3, pp. 1–13. Available at: https://doi.org/10.3390/ijms19051355.
10. Bensiameur-Touati, K. et al. (2017) ‘In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract of Nigella sativa’, Evidence-Based Complementary and Alternative Medicine. Edited by C.-H. Kim, 2017, p. 8427034. Available at: https://doi.org/10.1155/2017/8427034.
11. Bhatti, I. et al. (2016) ‘Effects of Nigella sativa ( Kalonji ) and Honey on Lipid Profile of Hyper lipidemic Smokers’, (August). Available at: https://doi.org/10.5530/ijper.50.3.9.
12. Cheikh-Rouhou, S. et al. (2008) ‘Black cumin (Nigella sativa L.) and allepo pine (Pinus halepensis Mill.) seed oils : stability during thermal oxidation at 60°C and 100°C.’, Journal of Food Composition and Analysis, 19(56), pp. 12–20.
13. Cobourne-Duval, M.K. et al. (2016) ‘The Antioxidant Effects of Thymoquinone in Activated BV-2 Murine Microglial Cells’, Neurochemical Research, 41(12), pp. 3227–3238. Available at: https://doi.org/10.1007/s11064-016-2047-1.
14. Dash, R. et al. (2021) ‘Emerging potential of cannabidiol in reversing proteinopathies’, Ageing Research Reviews, 65(August 2020), p. 101209. Available at: https://doi.org/10.1016/j.arr.2020.101209.
15. El-Gindy, Y. et al. (2020) ‘Hematologic, lipid profile, immunity, and antioxidant status of growing rabbits fed black seed as natural antioxidants’, Tropical Animal Health and Production, 52(3), pp. 999–1004. Available at: https://doi.org/10.1007/s11250-019-02091-x.
16. Elibol, B. et al. (2019) ‘Thymoquinone ( TQ ) demonstrates its neuroprotective effect via an anti-inflammatory action on the A β ( 1 – 42 ) -infused rat model of Alzheimer ’ s disease’, 0573. Available at: https://doi.org/10.1080/24750573.2019.1673945.
17. Food, J.M. et al. (2005) ‘An Investigation of the Analgesic and Anti-Inflammatory Effects of Nigella sativa Seed Polyphenols’, 8(4), pp. 488–493.
18. Hakim, A.S. et al. (2019) ‘Assessment of immunomodulatory effects of black cumin seed (Nigella sativa) extract on macrophage activity in vitro.’, International Journal of Veterinary Science, 8(4), pp. 385–389.
19. Hannan, Abdul, Ataur Rahman, A.A.M.S. 2 et al. (2021) ‘Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety’, Nutrients, 13, p. 1784.
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Published
2024-10-24
How to Cite
Dhyani Shubha, & Dr. Shatakshi. (2024). A study on the Therapeutic Effects of Nigella Seeds (Kalonji). Revista Electronica De Veterinaria, 25(2), 1010 - 1028. https://doi.org/10.69980/redvet.v25i2.1670
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Articles
