Phytomedicine: Nature's Defense Against Oxidative Stress
Abstract
Secondary metabolites, a diverse group of organic compounds found in various organisms, play a pivotal role in mitigating oxidative stress—a condition characterized by the imbalance between the production of reactive oxygen species (ROS) and the body's antioxidant defenses. These compounds, not essential for an organism's basic functions but critical for ecological interactions and defense mechanisms, exhibit an astonishing chemical diversity that encompasses alkaloids, terpenoids, phenolic compounds, polyketides, glycosides, lignans, and saponins. Secondary metabolites act as antioxidants through multiple mechanisms, including scavenging ROS, metal chelation, enhancing enzymatic antioxidant systems, and regenerating other antioxidants. However, challenges such as bioavailability, standardization, environmental concerns, and regulatory issues need to be addressed to harness the full potential of secondary metabolites. Despite these challenges, secondary metabolites remain a fascinating area of research with the potential to unlock innovative solutions for human health. This comprehensive review examines the mechanisms underlying oxidative stress, explores the antioxidant properties of phytochemicals, and discusses the potential of phytomedicine in preventing and managing oxidative stress-related conditions.
References
2. Maleki M., Ghorbanpour M., Kariman K., 2017. Physiological and antioxidative responses of medicinal plants exposed to heavy metals stress. Plant Gene, 11:247-254.
3. Leenders F., Groen N., de Graaf N., Engelse M.A., Rabelink T.J., de Koning E.J., Carlotti F., 2021. Oxidative stress leads to β-cell dysfunction through loss of β-cell identity. Front in Immunology, 12:690379.
4. Martins S.G., Zilhao R., Thorsteinsdottir S., Carlos A.R., 2021. Linking oxidative stress and DNA damage to changes in the expression of extracellular matrix components. Frontiers, 12.
5. McCord J.M., 2000. The evolution of free radicals and oxidative stress. The American Journal of Medicine, 108(8): 652-659.
6. Bhatti J.S., Bhatti G.K., Reddy P.H., 2017. Mitochondrial dysfunction and oxidative stress in metabolic disorders- A step towards mitochondria based therapeutic strategies. Biochimica et Biophysica Acta (BBA)- Molecular Basis of Disease, 1863(5): 1066-1077.
7. Whitehead N.P., Yeung E.W., Froehner S.C., Allen D.G., 2010. Skeletal muscle NADPH oxidase is increased and triggers stretch-induced damage in the mdx mouse. PLoS One, 5:e15354.
8. Mohamed J.B., Hunter M.I.S., 1986. Plasma antioxidants and lipid peroxidation products in duchenne muscular dystrophy. Clinica Chimica Acta, 155(2): 123-131.
9. Kowalczyk P., Sulejczak D., Kleczkowska P., Bukowska-Ośko I., Kucia M., Popiel M., Wietrak E., Kramkowski K., Wrzosek K., Kaczyńska K., 2021. Mitochondrial oxidative stress- A causative factor and therapeutic target in many diseases. International Journal of Molcular Sciences, 22(24): 13384.
10. Pizzino G., Irrera N., Cucinotta M., Pallio G., Mannino F., Arcoraci V., Squadrito F., Altavilla D., Bitto A., 2017. Oxidative stress: Harms and benefits for human health. Oxidative Medicine and Cellular Longevity, 8416763.
11. Ryter S.W., Tyrrell R.M., 1998. Singlet molecular oxygen (1O2): A possible effector of eukaryotic gene expression. Free Radical Biology and Medicine, 24(9): 1520-1534.
12. Gammone M.A., Riccioni G., D’Orazio N., 2015. Marine carotenoids against oxidative stress: effects on human health. Marine drugs, 13(10): 6226-46.
13. Özcan P., Fıçıcıoğlu C., Yıldırım O.K., Özkan F., Akkaya H., Aslan I., 2015. Protective effect of resveratrol against oxidative damage to ovarian reserve in female Sprague-Dawley rats. Reproductive Biomedicine Online, 31(3): 404-10.
14. Puthur J.T., Sameena P.P., Anjitha K.S., 2021. Functional aspects of plant secondary metabolites in metal stress tolerance and their importance in pharmacology. Plant Stress, 2:100038.
15. Gorni P.H., Pacheco A.C., Moro A.L., Silva J.F.A., Moreli R.R., de Miranda G.R., Pelegrini J.M., Zaniboni C.B., Spera K.D., Junior J.L.B., da Silva R.M.G., 2020. Elicitation improves the leaf area, enzymatic activities, antioxidant activity and content of secondary metabolites in Achillea millefolium L. grown in the field. Journal of Plant Growth Regulation, 40:1652-1666.
16. Bhattacharjee S., Banik N., 2020. Complementation of ROS scavenging secondary metabolites with enzymatic antioxidant defense system augments redox-regulation property under salinity stress in rice. Physiology and Molecular Biology of Plants, 26(8):1623-1633.
17. Averill-Bates D.A., 2023. The antioxidant glutathione. Vitamins and hormones, 121:109-141.
