Ayurvedic Nutraceuticals And Their Impact On Gut Microbiota

  • Dr. Shruti Salian
  • Dr.Sudeep Menon
Keywords: Ayurvedic Nutraceuticals, Gut Microbiota, Agni, Gut Health, Herbal Medicines, Doshas, Lifestyle, Health Outcomes, Digestion, Metabolism, Nutrients, Dinacharya, PathyaAhara, Dietary Components, Gastrointestinal (GI) Diseases

Abstract

Therapeutic approaches that target our microbial fellow-travelers are becoming more and more appealing as we understand more about the different functions the gut microbiota plays in maintaining homeostasis and how a disturbed microbiome may lead to disease. The connection between the gut microbiota and health has grown more clear as research tools for the microbiome have advanced. Since ancient times, people have utilized herbal remedies because they are "easy, convenient, affordable, and efficient." However, the therapeutic uses of herbal medicines are not well known for a variety of reasons, including their complicated structure, ambiguous active ingredients, and a lack of understanding of their underlying mechanisms. The relationship between the gut microbiota and herbal remedies has been the subject of an increasing number of studies in recent years. A balanced diet based on each person's Dosha, consistent sleep schedules, stress reduction methods, and a disciplined lifestyle are all recommended by Ayurvedic practices, and they all help to maintain a healthy gut microbiota. We can improve general health outcomes and avoid a number of disorders linked to microbial imbalance by comprehending and promoting the gut microbiome using these comprehensive approaches. The effect of Ayurvedic Nutraceuticals on Gut Microbiota will be covered in this essay.

Author Biographies

Dr. Shruti Salian

Assistant Professor, Department of Samhita and Siddhanta, (Ayurvedic Compendium and Basic Principles), B.S.D.T.'s Ayurved Mahavidyalaya, Wagholi, Pune, India

Dr.Sudeep Menon

Associate Professor, Department of Swasthavritta and Yoga, Bharati Vidyapeeth Deemed To Be University, College of Ayurved,Katraj, Dhankawadi Campus, Pune 411043

References

1. Qiao J, Lin X, Wu Y, Huang X, Pan X, Xu J, et al. Global burden of noncommunicable diseases attributable to dietary risks in 1990-2019. J Hum Nutr Diet. 2022;35(1):202-13.
2. Dureja H, Kaushik D, Kumar V. Developments in nutraceuticals. Indian journal of pharmacology. 2003;35(6):363-72.
3. Espín JC, García-Conesa MT, Tomás-Barberán FA. Nutraceuticals: facts and fiction. Phytochemistry. 2007;68(22-24):2986-3008.
4. Andlauer W, Fürst P. Nutraceuticals: a piece of history, present status and outlook. Food Research International. 2002;35(2-3):171-6.
5. Zheng, D.; Liwinski, T.; Elinav, E. Interaction between microbiota and immunity in health and disease. Cell Res. 2020, 30, 492–506. [Google Scholar] [CrossRef]
6. Brower, V. (1998). Nutraceuticals: Poised for a healthy slice of the healthcare market? Nature Biotechnology, 16, 728–731.
7. Kalra, E. K. (2003). Nutraceutical—Definition and introduction. AAPS PharmSci, 5, E25.
8. Santini, A. ,Tenore, G. C. , & Novellino, E. (2017). Nutraceuticals: A paradigm of proactive medicine. European Journal of Pharmaceutical Sciences, 96, 53–61.
9. Pereira, C. , Barros, L. , & Ferreira, I. C. F. R. (2017). Dietary Supplements: Foods, Medicines, or Both? A Controversial Designation with Unspecific Legislation. Current Pharmaceutical Design, 23, 2722–2730.
10. Swann, J. P. (2016). The history of efforts to regulate dietary supplements in the USA. Drug Testing and Analysis, 8, 271–282.
11. Quigley, E. M. M. (2019). Prebiotics and Probiotics in Digestive Health. Clinical Gastroenterology and Hepatology, 17, 333–344.
12. T.N. Jayasinghe, V. Chiavaroli, D.J. Holland, W.S. Cutfield, J.M. O’Sullivan The new era of treatment for obesity and metabolic disorders: Evidence and expectations for gut microbiome transplantation Frontiers in Cellular and Infection Microbiology, 6 (2016),
13. E. Vamanu, Polyphenolic nutraceuticals to combat oxidative stress through microbiota modulation Frontiers in Pharmacology, 10 (2019), p. 492, 10.3389/fphar.2019.00492
14. World Health Organization (2000). General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine (Geneva: World Health Organization).
15. Kamboj, V. P. (2000). Herbal medicine. Curr. Sci. 78, 35–39. doi: 10.2307/24103844
16. Boufridi, A., and Quinn, R. J. (2018). Harnessing the properties of natural products. Annu. Rev. Pharmacol. Toxicol. 58, 451–470. doi: 10.1146/annurev-pharmtox-010716-105029
17. Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., et al. (2012). Host-gut microbiota metabolic interactions. Science 6, 1262–1267. doi: 10.1126/science.1223813
18. Sekirov, I., Russell, S. L., Antunes, L. C. M., and Finlay, B. B. (2010). Gut microbiota in health and disease. Physiol. Rev. 90 859–904. doi: 10.1152/physrev.00045.2009
19. Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., and Knight, R. (2012). Diversity, stability and resilience of the human gut microbiota. Nature 489, 220–230. doi: 10.1038/nature11550
20. Etxeberria, U., Fernández-Quintela, A., Milagro, F. I., Aguirre, L., Martínez, J. A., and Portillo, M. P. (2013). Impact of polyphenols and polyphenol-rich dietary sources on gut microbiota composition. J. Agr. Food Chem. 61, 9517–9533. doi: 10.1021/jf402506c
21. Chen, F., Wen, Q., Jiang, J., Li, H. L., Tan, Y. F., Li, Y. H., et al. (2016). Could the gut microbiota reconcile the oral bioavailability conundrum of traditional herbs? J. Ethnopharmacol. 179, 253–264. doi: 10.1016/j.jep.2015.12.031
22. Chang, C. J., Lin, C. S., Lu, C. C., Martel, J., Ko, Y. F., Ojcius, D. M., et al. (2015). Ganodermalucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nat. Commun. 6:7489. doi: 10.1038/ncomms8489
23. Kato, M., Ishige, A., Anjiki, N., Yamamoto, M., Irie, Y., Taniyama, M., et al. (2007). Effect of herbal medicine Juzentaihoto on hepatic and intestinal heat shock gene expression requires intestinal microflora in mouse. World J. Gastroenterol. 13, 2289–2297. doi: 10.3748/wjg. v13.i16.2289
24. Sharon, G., Sampson, T. R., Geschwind, D. H., and Mazmanian, S. K. (2016). The Central Nervous System and the Gut Microbiome. Cell 167 (4), 915–932. doi: 10.1016/j.cell.2016.10.027
25. Flint, H. J., Duncan, S. H., Scott, K. P., and Louis, P. (2015). Links between Diet, Gut Microbiota Composition and Gut Metabolism. Proc. Nutr. Soc. 74 (1), 13–22. doi:10.1017/S0029665114001463
26. Koh, A., De Vadder, F., Kovatcheva-Datchary, P., and Bäckhed, F. (2016). From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. Cell 165 (6), 1332–1345. doi: 10.1016/j.cell.2016.05.041
27. Turroni, S., Brigidi, P., Cavalli, A., and Candela, M. (2018). Microbiota-Host Transgenomic Metabolism, Bioactive Molecules from the inside. J. Med. Chem. 61 (1), 47–61. doi: 10.1021/acs.jmedchem.7b00244
28. Thumann, T. A., Pferschy-Wenzig, E. M., Moissl-Eichinger, C., and Bauer, R. (2019). The Role of Gut Microbiota for the Activity of Medicinal Plants Traditionally Used in the European Union for Gastrointestinal Disorders. J. Ethnopharmacol 245, 112153. doi: 10.1016/j.jep.2019.112153
29. Khoobani, M., Hasheminezhad, S. H., Javandel, F., Nosrati, M., Seidavi, A., Kadim, I. T., et al. (2019). Effects of Dietary Chicory (ChicoriumIntybus L.) and Probiotic Blend as Natural Feed Additives on Performance Traits, Blood Biochemistry, and Gut Microbiota of Broiler Chickens. Antibiotics (Basel) 9 (1), 5. doi:10.3390/antibiotics9010005
30. Ismail, I. E., Abdelnour, S. A., Shehata, S. A., Abd El-Hack, M. E., El-Edel, M. A., and Taha, A. E. (2019). Effect of Dietary Boswellia Serrata Resin on Growth Performance, Blood Biochemistry, and Cecal Microbiota of Growing Rabbits. Front. Vet. Sci. 6, 471. doi:10.3389/fvets.2019.00471
31. AnushaSanivarapud, "Ancient Thali Diet: Gut Microbiota, Immunity, and Health", Yale Journal of Biology andMedicine, ISSNno:1551-4056,91,2018, Pages.177-184.
32. Louise Brunkwall, "The gut microbiome as a target for prevention and treatment of hyperglycaemia in type 2 diabetes: from current human evidence to future possibilities”, Diabetologia, ISSNno:1432- 0428, Vol.60,2017, Pages.943-951.DOI: 10.1007/s00125-017-4278-3
33. Alexander M Kurilshikov, "The effect of host genetics on the gut microbiome", Nature Genetics, ISSNno:1546-1718, Vol. 48(11),2016, DOI:10.1038/ng.3663
34. Anthony R. Bird, "The Impact of Diet and Lifestyle on Gut Microbiota and Human Health”, Nutrients, ISSNno:2072-6643, Vol. 7,2015, Pages.17-44.doi:10.3390/nu7010 017
35. D. H. Tambekar, "Antibacterial activity of some Indian Ayurvedicpreparations against enteric bacterial pathogens", Journal of Advanced Pharmaceutical Technology & Research, ISSNno:0976- 2094, Vol.2, Issue.1,2011, DOI:10.4103/2231-4040.79801
36. Goodman A., Kallstrom G., Faith J., Reyes A., Moore A., Dantas G., et al. (2011) Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice. Proc Natl AcadSci U S A 108: 6252–6257.
37. Lederberg J., McCray A. (2001) ‘Ome sweet’ omics: a genealogical treasury of words. The Scientist 15: 8.
38. Turnbaugh P., Hamady M., Yatsunenko T., Cantarel B., Duncan A., Ley R., et al. (2009) A core gut microbiome in obese and lean twins. Nature 457: 480–484.
39. Malla, M.A.; Dubey, A.; Kumar, A.; Yadav, S.; Hashem, A.; Abd Allah, E.F. Exploring the Human Microbiome: The Potential Future Role of Next-Generation Sequencing in Disease Diagnosis and Treatment. Front. Immunol. 2019, 9, 2868.
40. Gasmi A, Shanaida M, Oleshchuk O, Semenova Y, Mujawdiya PK, Ivankiv Y, et al. Natural Ingredients to Improve Immunity. Pharmaceuticals (Basel) 2023;16(4):528. doi:10.3390/ph16040528, PMID:37111285.
41. Tiwana G, Cock IE, Cheesman MJ. A Review of Ayurvedic Principles and the use of Ayurvedic Plants to Control Diarrhoea and Gastrointestinal Infections. Pharmacognosy Communications 2023;13(4):152– 162. doi:10.5530/pc.2023.4.25.
42. Conlon M.A., Bird A.R. The Impact of Diet and Lifestyle on Gut Microbiota and Human Health. Nutrients. 2015; 7(1):17–44. doi: 10.3390/nu7010017
43. Luke K. Ursell, "The Impact of the Gut Microbiota on Human Health: An Integrative View”, Cell, ISSNno:1476-4687, Vol.148,2012, DOI: 10.1016/j.cell.2012.01.035
44. Peterson, C.T.; Iablokov, S.N.; Rodionov, D.A.; Peterson, S.N. Personalized Response of Parkinson’s Disease Gut Microbiota to Nootropic Medicinal Herbs In Vitro: A Proof of Concept. Microorganisms 2023, 11, 1979.
Published
2024-06-23
How to Cite
Dr. Shruti Salian, & Dr.Sudeep Menon. (2024). Ayurvedic Nutraceuticals And Their Impact On Gut Microbiota. Revista Electronica De Veterinaria, 25(1S), 1499 -1509. https://doi.org/10.69980/redvet.v25i1S.1267